Sorry jd, you keep posting this message "small number of flawed studies" and then post a small number of industry sponsored PR exercises to support
your belief that aspartame is safe.
Here's one list of over 100 studies for you to be getting on with. Of the 7 reports that support Aspartame in this list, 6 of them are from
Rumsfeld's mates at the FDA.
Now, either individually rebut the entire list as flawed, or stop using that misleading statement and have the decency to be honest about the extent
of the valid, intelligent and authoritative research about the dangers of aspartame.
1970 Olney, Brain Damage in Infant Mice Following Oral Intake of Glutamate, Aspartate or Cysteine. Nature 1970;227:609-610.
1975 Olney JW, Aspartame as a Sweetener. NEJM 1975;292(23):1244-1245.
1977 Mishiro Y and Keneko H, Effect of a Dipeptide, Aspartame, on Lactic Acid Production in Human Whole Saliva. J Dent Res 1977;56(11):1427.
1979 Brunner RL, Vorhees CV, Kinney L, Butcher RE, et al., Aspartame: Assessment of Developmental Psychotoxicity of a New Artificial Sweetener.
Neurobehavioral Toxicology 1979;1:79-86.
1980 Olney, Brain Damage in Mice from Voluntary Ingestion of Glutamate and Aspartate. Neurobehavioral Toxicology and Teratology 1980;2:125-129.
1982 Uribe, Potential Toxicity of a New Sugar Substitute in Patients with Liver Disease. N Engl J Med 1982;173-174.
1983 Wurtman, Effects of Aspartame and Glucose on Rat Brain Amino Acids and Serotin. New England Journal of Medicine 1983;309(7):429-430.
1983 Wurtman RJ, Neurological Changes Following High Dose Aspartame with Dietary Carbohydrates. N Engl J Med 1983;309(7):429-430.
1984 Olney, Excitotoxic Food Additives Relevance of Animal Studies to Human Safety. Neurobehavioral Toxicology and Teratology 1984;6:455-562.
1984 Monte, Aspartame: Methanol and the Public Health. J Appl Nutr 36(1):42-54.
1984 Yokogoshi H,k Roberts CH, Canballero B, Wuetman RJ, Effects of Aspartame and Glucose Administration on Brain and Plasma Levels of Large Neutral
Amino Acids and Brain 5-Hydroxyindoles. Amer J Clin Nutr 1984;40:1-7.
1984 Mahalik MP and Gautieri RF, Reflex Responsiveness of CF-1 Mouse Neonates Following Maternal Aspartame Exposure. Research Communications in
Psychology, Psychiatry & Behavior 1984;9(4):385-403.
1985 Novick, Aspartame Induced Granulomatous Panniculitis. Ann Int Med 102(2):206-207.
1985 Grobelny D and Galardy RE, A Metabolite of Aspartame Inhibits Angiotensin Converting Enzyme. Biochemical and Biophysical Research Communications,
1985; 128(2):960-964.
1985 Wurtman, RJ, Aspartame: Possible Effects on Seizure Susceptibility. Lancet 1985;2(8463):1060.
1985 Ferguson JM, Interaction of Aspartame and Carbohydrates in an Eating Disordered Patient. Am J Psych 1985 Feb;142(2):271.
1986 Kulczycki A Jr., Aspartame Induced Urticaria. Ann Intern Med 1986;104(2):207-208.
1986 Pardridge WM, The Safety of Aspartame [Letter]. JAMA 1986;256(19):2678.
1986 Koehler SM, A New Dietary Caution for Migraine Sufferers. Dir in Appl Nut 1986;1:1-7.
1986 Kiritsky PJ and Maher TJ, Acute Effects of Aspartame on Systolic Blood Pressure in Spontaneously Hypertensive Rats. J Neural Transmission
1986;66(2):121-128.
1986 Yokogoshi H and Wurtman RJ, Acute Effects of Oral or Parenteral Aspartame on Catecholamine Metabolism in Various Regions of Rat Brain. J Nutr
1986;116:356-364.
1986 Walton, Seizure and Mania After High Intake of Aspartame. Psychosomatics 27:218-220.
1986 Drake ME, Panic Attacks and Excessive Aspartame Ingestion [Letter]. Lancet 1986;2(8507):631.
1986 Johns DR, Migrane Provoked by Aspartame. New Eng J Medicine 1986;315(7):456.
1986 Blundell JE, Hill AJ, Paradoxical Effects of an Intense Sweetener Aspartame on Appetite. Lancet 1986;1(8489):1092-3.
1986 Caballero B, Mahon BE, Rohr FJ, Levy HL, Wurtman RJ, et. al., Plasma Amino Acid Levels after Single Dose Aspartame Consumption in Phenylketonuria
Mild Hyperphenylalaninemia and Heterozygous State for Phenylketonuria. Journal of Pediatrics 1986;109(4):668-671.
1986 Bradstock MK, Serdula MK, Marks IS, et al., Evaluation of Reactions to Food Additives: The Aspartame Experience. AM J Clin Nutr 1986
Mar;43(3):464-9.
1986 Coulombe RA Jr., Sharma RP, Neurobiochemical Alterations Induced by the Artificial Sweetener Aspartame. Toxicol Appl Pharmacol
1986;83(1):79-85.
1987 Wurtman RJ, Aspartame Effects on Brain Serotonin. Am J Clin Nutr 1987 Apr;45(4):799-803.
1987 Maher TJ and Wurtman RJ, Possible Neurologic Effects of Aspartame, a Widely Used Food Additive. Environmental Health Perspectives
1987;75:53-57.
1987 Drogari E, Smith I, Beasley M, Lloyd JK, Timing of Strict Diet in Relation to Fetal Damage in Maternal Phenylketonuria: An International
Collaborative Study by the MRC/DHSS Phenylketonuria Register. Lancet 1987;2(8565):927-30.
1987 Elsas, et al., Changes in Physiological Concentrations of Blood Phenylalanine Produce Changes in Human Brain Function. Dietary Phenylalanine and
Brain Function Birkhauser Boston 1988;187-195.
1988 Roberts: Neurological, Psychiatric and Behavioral Reactions to Aspartame in 505 Aspartame Reactors. In: Wurtman and Ritter-Walker (eds.). Dietary
Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 373-376.
1988 Pinto and Maher, Aspartame, Phenylalanine and Seizures in Experimental Animals. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and
Brain Function. Boston: Birkhauser, 1988, pp. 95-103.
1988 Roberts, Reactions Attributed to Aspartame Containing Products: 551 Cases. Journal of Applied Nutrition 1988;40:85-94.
1988 Roberts, Neurological Psychiatric and Behavioral Reactions to Aspartame in 505 Aspartame Reactors. In: Wurtman and Ritter-Walker (eds.). Dietary
Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 373-376.
1988 Wurtman and Maher, Calculation of the Aspartame Dose for Rodents that Produces Neurochemical Effects Comparable to Those Occurring in People. In:
Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 144-148.
1988 Pinto JM, Mahea TJ, Administration of Aspartame Potentiates Pentylenetetrazole and Fluorothyl-Induced Seizures in Mice. Neuropharmacology
1988;27(1):51-55.
1988 Walton, The Possible Role of Aspartame in Seizure Induction. Proceedings of the first International Conference on Phenylalanine and the Brain.
Wurtman RJ, Walker E (eds.), Center for Brain Sciences and Metabolism Charitable Trust, Cambridge, 1987.
1988 Tollefson L, Monitoring Adverse Reactions to Food Additives in the US Food and Drug Administration. Regulatory Toxicology and Pharmacology
1988;8(4):438-446.
1988 Olney, Excitotoxic Food Additives Functional Teratological Aspects. In Progress in Brain Research, Vol 73 Biochemical Basis of Functional
Neuroteratology: Permanent Effects of Chemical on the Developing Brain, edited by Boer, GJ, et al., Elsevier, New York 1988.
1988 Tollefson L, Monitoring of Adverse Reactions to Aspartame Reported to the U.S. Food and Drug Administration. In: Wurtman and Ritter-Walker
(eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 317-326.
1988 Steinmetzer and Kunkel, Aspartame and Headache [letter]. N Engl J Med 1988;318(18):1201.
1988 Spiers, et al., Aspartame and Human Behavior: Cognitive and Behavioral Observations. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine
and Brain Function. Boston: Birkhauser, 1988, pp. 169-178.
1988 Sardesai, et. al., Effect of Aspartame in Diabetic Rats. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston:
Birkhauser, 1988, pp. 265-268.
1988 Matalon, et. al., Aspartame Consumption in Normal Individuals and Carriers for Phenylketonuria. In: Wurtman and Ritter-Walker (eds.). Dietary
Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 41-52.
1988 Guiso G, Caccia S, Vezzani A, et. al., Effect of Aspartame on Seizures in Various Models of Experimental Epilepsy. Toxicology and Applied
Pharmacology 1988;96:485-493.
1988 Johns, Aspartame and Headache. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp.
303-312.
1988 Fernstrom, Effects of Aspartame Ingestion on Large Neutral Amino Acids and Monoamine Neurotransmitters in the Central Nervous System. In: Wurtman
and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 87-96.
1988 Maher and Kiritsy, Aspartame Administration Decreases the Entry of Alpha-Methyldopa into the Brain of Rats. In: Wurtman and Ritter-Walker (eds.).
Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 122-126.
1988 Elsas, Aspartame and Migraine. N Engl J Med 1988;318(18):1201.
1988 Kim, et al., The Effect of Aspartame on 50% Convulsion Doses of Lidocaine. In: Wurtman and Ritter-Walker (eds.). Dietary Phenylalanine and Brain
Function. Boston: Birkhauser, 1988, pp. 127-130.
1988 Blundell, Effects of Aspartame on Appetite and Food Intake. In Dietary Phenylalanine and Brain Function, Wurtman and Ritter-Walker, Editors,
1988;Birkhauser, Boston, 275-295.
1988 Lipton RB, Newman LC, Cohen JS, Solomon S, Aspartame and Headache. The New England Journal of Medicine 1988 May 5;1200.
1988 Lipton, et al., Aspartame as a Dietary Factor in Headache. Neurology 1988;38:356.
1988 Lipton, et al., Aspartame as a Dietary Trigger of Headache. Headache 1989;29(2):90-2.
1988 Koehler SM, Glaros A, The Effect of Aspartame on Migraine Headache. Headache 1988;28:10-13.