How do they induce Cancer ?

Just was reading and article of how they have made some strides with Pancreatic cancer in mice --- So how do they give the mouse the cancer ?
It's possible to target organs in mice and just cause certain cancers ?

An experimental drug helped boost effectiveness of immunotherapy treatment against pancreatic cancer in mice, according to a recent study published this week in the Journal for Immuno Therapy of Cancer. Researchers out of Georgetown Lombardi Comprehensive Cancer Center and BioXcel Therapeutics, Inc, in Washington DC, found the drug BXCL701, an experimental dipeptidyl peptidase (DPP) inhibitor, increased the number of immune cells surrounding the tumor, resulting in slowing tumor growth, and in some mice, eliminated the cancer, according to a press release.

"We show that by combining this drug with immunotherapy, we were able to activate the immune system in such a way that it could melt pancreatic tumors quickly and even completely cure some mice." Allison Fitzgerald, Ph.D., at Georgetown Lombardi Comprehensive Cancer Center and co-first author of the study, told Fox News during an interview this week.

Health experts told Fox News pancreatic cancer has been resistant to immunotherapy. Researchers said in the report, that these findings provide early evidence that the drug could jump-start an immune response against the disease.

Link is from Fox

They breed mice with immunodeficiencies, then introduce chemicals or radiation combined with a high fat diet.

Read between the lines, America.

a reply to: Ravenwatcher
SB transposon enhanced with electroporation
Link

a reply to: tamusan

So if they know how to target and cause cancer shouldn't they know how to reverse it ?

Cancer was weaponized by 1960. Not only cancer but other diseases as well.

Two books; Dr. Mary's Monkey, and Me and Lee detail the processes and activities at a lab in New Orleans where a lot of this kind of work was being done in the 50s & 60s.

All the dastardly characters from the JFK/RFK murders, Iran-Contra, Bay of Pigs are part of the story and it is essential reading for any conspiracist.

Sorry, no aliens, but everyone else is there.

a reply to: Ravenwatcher

It easier to induce cancer than it is to cure it. Here is something that I had read recently about some progress made with pancreatic cancer.

Link

a reply to: Ravenwatcher

As I recall one way to induce cancer is to inject sodium nitrate as they do to rats and mice in labs.

Or the easy route just eat lots of processed food and don't wash your fruits and vegetables.

1. Sugar is in almost all processed food and beverages in one form or another. It's also an addictive substance.
2. Chemicals in commercial and unnatural nicotine products.
3. Microwave radiation via cell phones and tv antennae. Also, microwave ovens seals fail after repeated use.
4. Just blasting you with microwaves from hidden transmitters (proven to have been done to a UFO researcher, and yes he got cancer. I forget the guys name but it happened, they found the transmitter and destroyed it but too late.)

So 1-3, they? No, YOU give YOURSELF Cancer. They can if they want to, but 9 times out of 10 YOU bought it and used it by choice.
They market it but no one put a gun to your head and said "Stand in front of the microwave and stare at your food cooking then eat an entire cake by yourself for desert drinking Pepsi the whole time." That's all you.
(NOT "YOU" reading this, not most here I'm sure, that's the figurative "you" I'm using. Them. Mentally, physically, spiritually unhealthy people.)

a reply to: Ravenwatcher

This is a good question, in fact there are many ways to induce cancer in an animal model and it’s all based on gene expression. All of our cells have the same exact DNA, different cells express different areas of our genes to differentiate and perform their function. So to induce cancer you need to modify gene expression while also suppressing or removing T cell function.

T cells are important in cancer because this is our own tissue, antibody function will be limited because it is our own cells and not an external pathogen. CD4 or helper T cells are important because of the th1 response in regulating inflammatory signaling to induce an immune response. CD8 or cytotoxic T cells are important because they will identify and destroy abnormal tissue like cancer cells.

One way to induce cancer is to breed athymic mice or remove the thymus in mice. We need to be careful because many strains of mice have a backup thymus called the cervical thymus which can mess up our studies. T-cells mature in the thymus, removing it causes a loss of T cell function and B cell function. T cells are trained in the thymus and they also train B cells to produce antibody responses. You remove T cells and you can graft cancers using human tissue to study them in the animal model.

You can also use an electrical current in cells. Electroporation creates channels or holes in the cell that we can transfer genetic material through. This would be beneficial in an embryo because those genes would be incorporated in the developing embryo.

You can create genetic issues through breeding and make the animal model sensitive to changes. Then you can induce cancer by using a viral vector to insert genes in the nucleus.

You can also knockdown apoptotic pathways and other cell control methods that suppress T-cell function in the tumor microenvironment while boosting anti inflammatory signaling. This will prevent T-cells from going after the tumor cells and infiltrating the tumor because regulatory T cells tell them to stop. IL-10 and PD-1 are popular targets to push this both ways.

Once you have the tumor, you target proteins and signal pathways to determine treatment targets. Monoclonal antibodies can block expression of these targets and then we can see if it helps or stops tumor growth and modify targets to create a medicine to treat the cancer.

Popular methods are stopping T-cell exhaustion, training T-cells to target tumor, and using monoclonal antibodies to modulate the immune response in the tumor micro environment which is different and confuses and exhausts our cells allowing the tumor to grow unchecked.