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Ebola kills Liberia doctor despite ZMapp treatment
A Liberian doctor has died despite taking an experimental anti-Ebola drug, Liberia's information minister says.
Abraham Borbor was one of three doctors in Liberia who had been given ZMapp and were showing signs of recovery.
ZMapp has been credited with helping several patients recover, including two US doctors.
……Meanwhile, Japan said it was ready to allow shipments of an experimental anti-viral drug to help combat the Ebola outbreak.
It is not clear whether T-705 (or Avigan) will actually work against Ebola, and no monkey or human trials of the drug have been done, the BBC's Rupert Wingfield-Hayes in Tokyo reports.
T-705 was developed by Japan's Toyama Chemicals company for use against new strains of influenza. It was approved by the Japanese government earlier this year.
A company spokesman says the firm believes the similarity between flu viruses and Ebola means Avigan could be effective.
Japan says it is ready to ship Avigan even without approval by the World Health Organization.
New Thinking About Ebola Treatments
…There are currently no approved drugs to treat infection with the Ebola virus… The new proposal would fill the gap by using drugs that have already been approved to treat other diseases and repurposing them to treat Ebola as well.
This approach is well worth pursuing, given the crisis. Two broad categories of drugs are being mentioned. Existing drugs that seek to disable the viruses responsible for other diseases, for example, might conceivably disable the Ebola virus. And drugs that temper the body’s response to other diseases by reducing severe inflammation might also dampen the often fatal inflammatory response in Ebola patients.
….Even those who have backed the use of existing drugs because “desperate situations justify desperate measures” have stressed that there needs to be some evidence a drug might work.
Intravenous ascorbic acid infusion was safe and well tolerated in this study and may positively impact the extent of multiple organ failure and biomarkers of inflammation and endothelial injury.
Outbreak in West Africa
An Ebola epidemic that has been sweeping through West Africa since January has proven to be the most devastating single outbreak of the disease in history.
originally posted by: Iamthatbish
I believe we can be healed with vitamin C, I have however gone with citrus at home instead of purchased vitamins.
There's just something wrong in a bottle of vitamin C having the number one ingredient of sugar.
originally posted by: Dingo80
....Those with the Weakest Immune Systems will be the First to go.
Review of patient ages and outcomes reveals that H5N1 attacks are especially lethal in pre-adults and young adults, while older victims tend to have milder attacks and to survive. This is consistent with the frequent development of a cytokine storm in the afflicted. Few persons over 50 years of age seem to have become infected by H5N1, and very few have died after suffering an H5N1 attack. Instead, the age-fatality curve of H5N1 influenza attacks in humans resembles that of the 1918 Spanish pandemic flu, and is the opposite of the mortality curve of seasonal flu strains, since seasonal influenza preferentially kills the elderly and does not kill by cytokine storm.
A cytokine storm is an overproduction of immune cells and their activating compounds (cytokines), which, in a flu infection, is often associated with a surge of activated immune cells into the lungs. The resulting lung inflammation and fluid buildup can lead to respiratory distress and can be contaminated by a secondary bacterial pneumonia—often enhancing the mortality in patients.
This little-understood phenomenon is thought to occur in at least several types of infections and autoimmune conditions, but it appears to be particularly relevant in outbreaks of new flu variants.
Multiple Vaccines in the Works Against Ebola
U.S. government scientists will start testing an experimental vaccine against Ebola in people next week, starting out with 20 healthy adults. The same vaccine, made by GlaxoSmithKline in collaboration with the National Institutes of Health, will be tested in the coming weeks in Britain, Gambia and Mali.
It’s one of several Ebola vaccines in the pipeline. Here are some others:
Canada’s VSV-EBOV: …..Experts say it works a little like the rabies vaccine, in that it protects both before and after exposure to the virus. It’s made using a virus called vesicular stomatitis virus (VSV).
Profectus Biosciences: …..also based on VSV. ……
Crucell: …….(to) protect against several strains of Ebola, as well as against Marburg, a related virus. ….the first tests will start in 2015 or early 2016.
Rabies-based vaccine: …..uses a genetically engineered version of the rabies virus to protect against rabies and Ebola at the same time. …..
Immunovaccine Inc.: ….uses immune stimulating protein from the Ebola virus plus compounds called adjuvants……