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Originally posted by Unity_99
Yes but, why are you asking about the worth of gold when I think there are many articles online about it?
By combining bioconjugated silica-based gold nanoshells, which scatter light in the near-infrared, with a portable FDA-approved reflectance confocal microscope, we first validate the use of gold nanoshells as effective reflectance-based imaging probes by evaluating the contrast enhancement of three different HER2-overexpressing cell lines. Additionally, we demonstrate the ability to detect HER2-overexpressing cells in human tissue sections within 5 min of incubation time. This work supports the use of targeted silica-based gold nanoshells as potential real-time molecular probes for HER2-overexpression in human tissue.
Gold-Silica-Gold Nanosandwiches: Tunable Bimodal Plasmonic Resonators Alexandre Dmitriev, Dr. 1 *, Tavakol Pakizeh 1, Mikael Käll, Prof. 1, Duncan S. Sutherland, Prof. 1 2 1Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden, Fax: (+46) 317-723-134 2Interdisciplinary Nanoscience Center (iNANO), Department of Physics and Astronomy, University of Aarhus, 8000 Aarhus C, Denmark email: Alexandre Dmitriev ([email protected]) *Correspondence to Alexandre Dmitriev, 1Department of Applied Physics, Chalmers University of Technology, 41296 Göteborg, Sweden, Fax: (+46) 317-723-134 We acknowledge financial support from the European Commissions Marie Curie Fellowship program (A.D.), the Swedish Institute (T.P.), the Swedish Foundation for Strategic Research, and the Swedish Research Council. Keywords gold • layered materials • nanostructures • self-assembly • surface plasmon resonance Abstract A metal-dielectric sandwich nanostructure, fabricated by a self-assembly technique, has a bimodal resonant response at optical frequencies due to dipolar plasmon hybridization (see picture). The degree of electromagnetic coupling in the system can be controlled by either varying the aspect ratio of one of the disks in the layered structure, or by altering the thickness of the dielectric spacer between the plasmonic components.