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Producing commercially important recombinant proteins in large quantities has long been a headache for biotechnology companies, particularly if the protein of interest has a tendency to fold incorrectly.
www.nature.com...
"Scientists think if the proteins misfold, they can become infectious..."
Misfolded Proteins Infectious
…prions are notoriously difficult to break down… "We don't know why prions are so highly stable, but they are extremely hard to destroy. Indeed, one standard method of decontamination - soaking in fomaldehyde - actually stabilises the prions."
New Methods Work to Killing Prions
The scientists who insist misfolded proteins are benign are generally employed or funded by, or associated with chemical and drug companies.
Originally posted by HowardRoark
A good submission, overall, however I think that this statement:
The scientists who insist misfolded proteins are benign are generally employed or funded by, or associated with chemical and drug companies.
is a little too general.
While it might be true, It would be difficult to prove conclusivley and it adds a percieved bias.
Originally posted by HowardRoark
Billybob, no one is out there trying to "depopulate" the earth through engineered viruses.
Viruses mutate enough on thier own, we don't have to do it for them.
Originally posted by twitchy
"Who profits from the mad cow terror?"
100777.com...
MONDAY, FEBRUARY 5. 2001 Mark Purdey, the very bright British farmer who claims mad cow disease is really caused by the insecticide Phosmet, has had some trouble. His house was burned down. Corporate Watch magazine (issue 12) reports that his barn suddenly collapsed and his library of med/science materials was damaged. Purdey was shot at. His phone lines were cut. Purdey went to court to defend his right not to give his cows Phosmet. His lawyer, who won the case, died in a car crash. Purdey's veterinarian, who claimed Purdey had perhaps found a clue to mad cow disease, also died in a car accident.
Phosmet is spread on the spines of cows to eradicate a pest. It is manufactured by Zeneca Corp., a spinoff of the Brit chem giant Imperial Chemical Industries (ICI). ICI was originally founded out of the famous explosives firm, Nobel. ICI was one of those big companies which was involved with the Nazi cartel IG Farben. Zeneca makes the cancer drug Tamoxifen, which has been linked to ovarian cancer.
Not a pretty picture. Phosmet, which is an organophosphate compound, comes out of a long line of research on nerve gas. IG Farben pioneered that research long ago. ...
Originally posted by soficrow
...Mark Purdey, the very bright British farmer who claims mad cow disease is really caused by the insecticide Phosmet, has had some trouble.
Originally posted by soficrow
Good links Azeari - thanks.
FYI - numerous things are known or suspected to make proteins misfold - chemicals, including organophosphates like DDT and the one Purdey's on about, viruses, heavy metals, electro-magnetic fields - then new strains emerge when prions are exposed to any of these things, or new species, cells, temperature changes. ...IMO - Purdy may be right about what's triggering Mad Cow in England...
...also FYI - a group of people suspect that the New Guinea tribe was purposefully infected so that the disease could be studied and monitored. ...The key researcher was Gadjusek (sp?) - haven't followed up on this, just aware of allegations.
.
Originally posted by HowardRoark
Hey, I beleve that we do infact create a lot of environmental issues ourselves. Not out of some wierd plot, but simply out of blind ignorance. the pattern is simple and has been repeated a number of times.
Lead Paint, asbetos, PCBs, Benzene, MTBE, these were all viewed as benificial to us at one time.
One angle that hasn't been mentioned is hamburger ("mince", over here). When you think about the fact that a typical pound of hamburger could contain bits from perhaps hundreds of different animals (I saw the exact stat once, can't find it now), that really increases the odds of any one portion being infected.
Originally posted by superdude
I understand what you're saying about knowing it is solely from one animal, however does this in any way help to ensure that BSE is not present? Is there special testing done when the animal is slaughtered?
No, it just improves the odds of it NOT being present in that particular meal. The odds of any single animal having it is astronomically smal, but if you eat someting made from tiny pieces of 500 (or whatever) animals, the odds are increased by a factor of 500. The odds are still small, but keep doing it over & over again, keep eating supermarket hamburger 2 or 3 times a week...eventually you've eaten a tiny bit of thousands of individual animals. Maybe tens of thousands over a lifetime?
Originally posted by soficrow
...Fibromuscular dysplasia (FMD) appeared in the early 1900's. It is caused by a misfolded protein called a-smooth muscle actin (a-SMA), which takes over connective tissue stem cells and makes them mutate into myofibroblasts. ...Looks like the first ever prion disease, causes heart disease, cancer, stroke yada yada. Have posted info about it everywhere here.
Originally posted by mattison0922
Originally posted by soficrow
...Fibromuscular dysplasia (FMD) appeared in the early 1900's. It is caused by a misfolded protein called a-smooth muscle actin (a-SMA), which takes over connective tissue stem cells and makes them mutate into myofibroblasts. ...Looks like the first ever prion disease, causes heart disease, cancer, stroke yada yada. Have posted info about it everywhere here.
Soficrow, good post... Prion diseases have been a 'hobby topic' of mine for some time now.
Just for clarification: FMD was not the first prion disease. Scrapie a prion disease that affects sheep was described in the early 18th century.
Originally posted by Azeari of the Radiant Eye
I thought it might be worth reposting a link to this thread: ATS Thread
it makes sense to at least try & reduce the number of individual animals you eat. Traceability makes sense, too, as does organic (or something close at least).
Bad edit - I meant the first prion disease in humans. ...New spin is trying to say cannibals had prion diseases millions of years ago - but that's "new info" - looks like bull puckey to me.
Originally posted by mattison0922
Bad edit - I meant the first prion disease in humans. ...New spin is trying to say cannibals had prion diseases millions of years ago - but that's "new info" - looks like bull puckey to me.
Gotcha. Hmmm.... haven't heard the 'cannibals had them millions of years ago' thing... I would tend to agree with your assessment though....I wonder HOW they came to this conclusion. Prion proteins are hardy indeed... but certainly don't persist for millions of years. Perhaps you've got a link available?