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A Novel Prion Disease Associated with Diarrhea and Autonomic Neuropathy
Human prion diseases, although variable in clinicopathological phenotype, generally present as neurologic or neuropsychiatric conditions associated with rapid multifocal central nervous system degeneration that is usually dominated by dementia and cerebellar ataxia. Approximately 15% of cases of recognized prion disease are inherited and associated with coding mutations in the gene encoding prion protein (PRNP). The availability of genetic diagnosis has led to a progressive broadening of the recognized spectrum of disease.
Abnormal forms of prion protein that were found in multiple peripheral tissues were associated with diarrhea, autonomic failure, and neuropathy.
Novel Prion Disease With Peripheral Symptoms Identified
…the affected family presented with 11 members showing symptoms of this syndrome, with severe diarrhea; neuropathy, manifesting as loss of feelings in feet; and loss of bladder control and postural hypotension. The researchers studied 6 of the affected family members in detail, along with autopsy or biopsy samples obtained from 5 of them, and found abnormal prion protein deposits.
…Prion diseases have so far been confined to the brain, but in this condition, the abnormal prion proteins were found all over the body.
I learned more about that other prion disease than I really wanted to, including it's rather disturbing success rate of transmission, for lack of a better term with something that isn't actually 'alive'.
Can you clarify on this one, they are saying it's genetic and not transmitted for developing it? I learned more about that other prion disease than I really wanted to... I looked and didn't see anything explaining the 'other than 15%', for a cited number?
We identified a PRNP Y163X truncation mutation and describe a distinct and consistent phenotype ...
Our results confirm that truncating mutations are frequent in both familial and sporadic NF1 cases.
...I haven't run across anything that can be consumed to help protect from prions. …Have you any knowledge of how to possibly help people to control these ...?
New Inhibitors of Scrapie-Associated Prion Protein Formation in a Library of 2,000 Drugs and Natural Products
Several classes of compounds were represented in the 17 most potent inhibitors, including naturally occurring polyphenols (e.g., tannic acid and tea extracts), phenothiazines, antihistamines, statins, and antimalarial compounds. ...many are either approved human drugs or edible natural products...
...If the damage was done, it's been done already and nothing anyone can do would stop the long term end result now.
We studied 6 of 11 affected family members in detail, along with autopsy or biopsy samples obtained from 5 family members.
...a distinct and consistent phenotype of chronic diarrhea with autonomic failure and a length-dependent axonal, predominantly sensory, peripheral polyneuropathy with an onset in early adulthood. Cognitive decline and seizures occurred when the patients were in their 40s or 50s. The deposition of prion protein amyloid was seen throughout peripheral organs, including the bowel and peripheral nerves. Neuropathological examination during end-stage disease showed the deposition of prion protein in the form of frequent cortical amyloid plaques, cerebral amyloid angiopathy, and tauopathy. A unique pattern of abnormal prion protein fragments was seen in brain tissue.
...We interact with bacteria, fungus, viruses, and prions all day long. I am not afraid of them. If you fear something it senses your stress and it opens a door. I am finding how to live better with these companions in the environment. I will treat those in my only kingdom, my body, as my subjects and hope that if I treat them well we can live a good life together. Hopefully they will fight with me to kill bad invaders.
I suppose some would say that I am nuts because I think these things are my friends....I think they are right myself. I guess I will see if it works, I know fear and stress screw up our immune system so that is a big plus on my theory.
...beginning to sense that the whole prion thing is not evolutionary, but just another part of the planned great die off,... which the earth is undergoing presently......
It strikes me strongly that it is very interesting the gov boys are setting up DNA collection across the nation rather swiftly these days......and it may just be it has zero to do with the NWO.....and everything to do with PRIONS...........
think ABOUT IT.................