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Originally posted by soficrow
reply to post by DevolutionEvolvd
Current evidence indicates that dietary cholesterol accounts for maybe up to 10% of circulating serum cholesterol in hypercholesteremia.
Nonetheless, you keep pushing the idea that diet controls serum cholesterol levels - and that dietary intervention restores cholesterol homeostasis. You are full of it - misinformed, uninformed, decades behind the science - and liable to hurt people with your bs.
When I'm choosing a dietary plan for my meals of the day, I'm not much thinking of avoiding foods high in cholesterol, rather in getting the correct nutrients so that my body will better manage itself.
Originally posted by soficrow
reply to post by DevolutionEvolvd
Current evidence indicates that dietary cholesterol accounts for maybe up to 10% of circulating serum cholesterol in hypercholesteremia.
Nonetheless, you keep pushing the idea that diet controls serum cholesterol levels - and that dietary intervention restores cholesterol homeostasis. You are full of it - misinformed, uninformed, decades behind the science - and liable to hurt people with your bs.
Elevated cholesterol in the blood is due to abnormalities in the levels of lipoproteins
Statins act by competitively inhibiting HMG-CoA reductase, the first committed enzyme of the HMG-CoA reductase pathway.
en.wikipedia.org...
Liver cells sense the reduced levels of liver cholesterol and seek to compensate by synthesizing LDL receptors to draw cholesterol out of the circulation.
HMG-CoA reductase is active when blood glucose is high. The basic functions of insulin and glucagon are to maintain glucose homeostasis.
en.wikipedia.org...
Originally posted by soficrow
reply to post by DevolutionEvolvd
You are to medicine what computer salespeople are to the communications industry - trained to parrot key phrases and razzle-dazzle ignorant consumers, but essentially ignorant and in the end, dangerous.
Right now, global corporate industries are teaming it against real-life humans, blaming the victims - and getting the victims to blame each other.
1. The arsenic in the water from the goldmine is worse than the cadmium in the soil from the cadmium dispersal experiments;
2. The Bisphenol A in food packaging and dental sealants caused more NCDs than the ultra-fine particles from the coal burning plants;
3. The food industry creates more infectious misfolded proteins than Big Pharma; and on and on.
If (industrial pollutants and contaminants) are the reasons we see the current explosions in rates of chronic disease, then why do we see these diseases in nations and people without exposure to (industrial pollutants and contaminants) ?
……..While China’s factories crank out consumer goods for the planet, workers in these plants – who often toil in horrible conditions – are seeing their rates of respiratory illness and cancer soar.
The causes of deaths in an industry-dense area: example of Dilovasi
It is known that being exposed to air pollution for a long time increases the risk of respiratory illnesses and respiratory system cancers (20). It has also been observed that the mortality rate related to lung cancer has increased due to air pollution caused by industry (21,22). According to the World Health Report 2004, 12.5% of the deaths in the world are caused by cancer (12).
……Approximately 30,000 chemicals are commonly used today in industry and less than 1% of these have been subjected to a detailed assessment in terms of their toxicity and health risks (24). Some pollutants, such as suspended particular matter, sulphur dioxide, nitrogen dioxide, ozone, and carbon monoxide, are used for routine air quality monitoring.
…….It may be possible for the chemical pollutants to enter the human body via the food chain and by the pollutants in both air and water. ….
…………………………
Also see: Air quality and health
The main functions of the liver is to process nutrients from food, make bile, remove toxins from the body and build proteins.
..........
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. ……The liver is thought to be responsible for up to 500 separate functions, usually in combination with other systems and organs.
A New Understanding of Protein Mutation Unfolds
Most diseases with a genetic basis involve a mutation in some gene that affects how much of its protein is made or how well that protein works. However, a growing body of research indicates that this scenario may not be universally true. .....
You are to medicine what computer salespeople are to the communications industry - trained to parrot key phrases and razzle-dazzle ignorant consumers, but essentially ignorant and in the end, dangerous.
You are full of it - misinformed, uninformed, decades behind the science - and liable to hurt people with your bs.
Wotta guy. 3 posts of narrative bs, not one single link to back up your claims - yet you have the gall to lay out a HUGE list of demands, expecting me to drop my own priorities to play your silly games. Get a grip. I'm not here to do your research for you. Oh yeah, you did post an inaccessible 2005 op-ed piece for another member. ..........BLEEP.............Educate yourself! ...Here, let me help you get started. ..............BLEEP............
.I confess I do not understand your agenda, although you clearly have one. Are you simply arguing to support the legitimacy of 'alternative health' solutions, or are you trying to defend corporate industry from liability charges?
can you please describe the biochemical processes associated with Prion Disease and Obesity?
So how do misfolded proteins affect the biochemical pathways that drive fat deposition and obesity?
dietary intervention absolutely corrects most cases of dyslipidemia. So...if diet isn't causing [hypercholesterolemia], in most cases, why does dietary intervention correct the problem?
[in response to an association you've so gladly pointed out] ..but how does this describe the methods by which Prions cause obesity?
......I've consistently asked you, from my first post, to describe the mechanisms that would account for the observed association between obesity (and high cholesterol) and Prion disease.
Originally posted by soficrow
For those who still buy the corporate spin that obesity epidemics are occurring in countries without pollution - guess what! There are NO countries without pollution and environmental contamination.
In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an inverted U-shaped dose response. Such environmental factors that would seem to produce positive responses have also been termed “eustress”
en.wikipedia.org...
without even knowing the difference between intracellular high cholesterol and hypercholesterolemia
1971 - Previous studies have described the exchange of free cholesterol molecules of macrophage membranes with those of serum lipoproteins (1). Exchangeable cholesterol was found in two compartments. The rapidly exchanging compartment was identified as the plasma membrane, and the slowly exchanging compartment was associated with intracellular membranes (2). …..Under physiological and pathological conditions macrophages are exposed to other forms of both free cholesterol and CE's. Effete erythrocytes, tissue cells, and chylo-microns are taken up by phagocytosis (4-6), and subsequently are localized within cytoplasmic phagolysosomes. Many of their constituents are then degraded by acid hydrolases (7-9).
Similar events take place under in vitro culture conditions and may lead to the formation of an intralysosomal compartment of free and esterified cholesterol, clearly distinct from the membrane-associated intracellular pool. The processing and fate of cholesterol and CE's within the digestive vacuole is poorly understood.
In this paper we describe the formation of intralysosomal pools of particulate-free and esterified cholesterol, their intracellular processing and excretion from the macrophage, and their influence on the kinetics of exchange. In addition, a lysosomal cholesterol esterase has been characterized and its function evaluated in cell lysates and in the intact macrophage.
1996 - Like cholesterol, 250HC was removed from cells by an extracellular acceptor such as high density lipoprotein. Unlike cholesterol,250HC was also rapidly and extensively removed from cells by serum albumin, but not by ovalbumin.The differential removal of oxysterols and cholesterol from cells by albumin allows separation of cellular effects due to oxysterols and cholesterol.
And we know that this isn't a phenomenon of increased contaminant exposure from pollution, etc. because once this specific type of diet is cessated, disease incidence begins to decrease (with cancer incidence being the most controversial), regardless of industrialization.
Originally posted by soficrow
Please feel free to provide references proving that cholesterol cannot and does not ever leave the cell to enter serum, blood stream or other body system.
Elevated cholesterol in the blood is due to abnormalities in the levels of lipoproteins
en.wikipedia.org...
Familial hypercholesterolaemia (FH) is the most thoroughly studied lipoprotein disorder.
[snip]
The diagnosis is based on elevated plasma LDL cholesterol, the presence of a family history of premature CAD and the presence of xanthomas. A molecular diagnosis is sometimes required. Defects at the LDL-R gene that alter the function of the LDL-R protein and its function are the cause of FH(Figure 2 (7)); this causes accumulation of LDL particles in plasma.
www.springerlink.com...
mice lacking Pcsk9 have increased levels of hepatic LDL receptors, and they remove LDL from the plasma at an accelerated rate.11 Thus, high levels of PCSK9 lead to high plasma levels of LDL cholesterol, whereas low levels of PCSK9 lead to low LDL cholesterol levels.
www.nejm.org...=articleBackground
3.2 percent had a sequence variation in PCSK9 that was associated with a 15 percent reduction in LDL cholesterol and a 47 percent reduction in the risk of CHD
These data indicate that moderate lifelong reduction in the plasma level of LDL cholesterol is associated with a substantial reduction in the incidence of coronary events, even in populations with a high prevalence of non–lipid-related cardiovascular risk factors.
www.nejm.org...
Please feel free to provide references proving that cholesterol cannot and does not ever leave the cell to enter serum, blood stream or other body system.