posted on Dec, 7 2009 @ 01:04 PM
I can't really put mine in a "least to most" favorite order...though i would have to say my favorite villain is definitely Sephiroth.
I really liked the demon from Doom as well.
Some others that i feel deserve to be in the top 10:
Wesker (from the Resident Evil series)
Inky, Blinky, Pinky, & Clyde (the ghosts from PacMan)
Gannon (from The Legend of Zelda series)
The wind tunnel stage
Hogger (World of Warcraft)
Diablo (Diablo 1, 2, and soon to be 3)
"The Thief" (From the infamously famous "Zork" text based game)
and the one, perhaps more infamous than Sephiroth himself:
yes yes, your main squeeze, perhaps now even your wife.
The one boss who, at always the worst time, wants you to "shut that damn thing off so we can go hang out with her friends"