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Authorities said Beaudette was shot at least once in the upper torso, The Los Angeles Times reported. His daughters, ages 2 and 4, were unharmed in the shooting that reportedly occured at about 4:45 a.m. Beaudette took the girls camping so his wife, a doctor, could study for an exam, according to the reports. He worked as a scientist for a pharmaceutical company and he and his wife were about to move to the Bay Area. Deputies said they had no leads, no suspect and no motive, KCBS Los Angeles reported.
His family remembered him as a devoted father who “found true joy” in his life with his children. “The grief and trauma this loss has caused our close-knit family is indescribable,” the family’s statement read. The park was the backdrop for the TV series “M.A.S.H.,” as well as the movies “Butch Cassidy and the Sundance Kid” and the original “Planet of the Apes,” according to the paper.
Despite the promise of precisely targeted or otherwise functionalized polymeric particulate drug delivery vehicles, typical biocompatible particles are generally not amenable to facile and selective surface modification.
Herein, we report the development of a simple, mild, and chemoselective strategy for the conjugation of biologically active molecules to the surface of dextran-based microparticles. Alkoxyamine-bearing reagents were used to form stable oxime conjugates with latent aldehyde functionality present in reducing carbohydrate chain ends.
We demonstrate the functionalization of dextran-based microparticles with a fluorophore as well as a cell-penetrating peptide sequence, which facilitated the delivery of cargo to nonphagocytic cells leading to a 60-fold increase in the expression of a reporter gene when plasmid DNA-loaded particles were used.
In addition, the AcDX particles are especially promising for targeted drug delivery, because their termini can be useful for further functionalization...
As a result, the multidrug-loaded pH-responsive PSi@AcDX nanocomposites (drug-loaded PSi@AcDX) were obtained. To facilitate the intracellular drug delivery ,..a class of cationic peptides known to facilitate the delivery of cargos across the cell membrane ... was chemically conjugated onto the external surface of the nanocomposites ...After incubation, cells were treated with trypan blue...
The objective is, again, to minimize the unwanted side effects of drugs by reducing premature release while maximizing their concentration at the target site by ligand–receptor interactions.
This technique makes use of the fact that certain membrane receptors are overexpressed in cancer cells160161162.
The combination of receptor-targeted chemotherapy with nanoparticle drug carriers and physical stimulus (e.g., heat, US, pH change) to trigger drug release is extremely promising in chemotherapeutics. ...
originally posted by: TrueBrit
a reply to: Gargoyle91
Those poor kids...
People say that kids are like rubber, because they bounce back... but something like that never leaves you. I hope they find whomever it is that did this, and I hope that individual suffers mightily. Its one thing to be a contract assassin, but to be one who will take a man out in front of his children, rather than engineer a moment when they are alone? Scum, pure and simple.
originally posted by: Gargoyle91
a reply to: galaga
They would have found a gun on scene . I'm interested in what they find out from his kid's
originally posted by: galaga
a reply to: Gargoyle91
Ok, I would have to see the crime scene photos to determine whether or not this was a actual murder as opposed to an accident.
originally posted by: lordcomac
originally posted by: galaga
a reply to: Gargoyle91
Ok, I would have to see the crime scene photos to determine whether or not this was a actual murder as opposed to an accident.
How do you accidentally shoot someone in the chest? In a tent? Next to their children? In a national park?
I mean, a random act of violence maybe, but even that seems awful coincidental.
Maybe the wife paid to have him killed- life insurance is good money, and some people are just nuts.
originally posted by: mzinga
a reply to: TEOTWAWKIAIFF
Guys, big pharma exec? He was an associate director at Allergan.. That isn't a big exec. Also, you have any idea what Allergan makes? Oh ya, Botox, Breast Implants, Eye drops and fillers. It isn't always a conspiracy.
Not unless more than one person was involved with planning the murder.
When someone is murdered it IS a conspiracy.
Trying to solve the mystery killing of a father who was fatally shot inside his tent while he was camping with his young daughters in Malibu State Creek Park, Los Angeles County sheriff’s investigators are now examining several unsolved earlier shootings in the area over the last couple of years.
originally posted by: JimNasium
When someone is murdered it IS a conspiracy. Also an associate director is a big executive. So, twice wrong.
"Conspiracy" is anyone working in concert w/another or others to commit any crime is guilty of 'conspiracy'
Unless they changed the legal definition since I was a Ca. cop.
originally posted by: JimNasium
When someone is murdered it IS a conspiracy. Also an associate director is a big executive. So, twice wrong.
"Conspiracy" is anyone working in concert w/another or others to commit any crime is guilty of 'conspiracy'
Unless they changed the legal definition since I was a Ca. cop.
originally posted by: galaga
originally posted by: JimNasium
When someone is murdered it IS a conspiracy. Also an associate director is a big executive. So, twice wrong.
"Conspiracy" is anyone working in concert w/another or others to commit any crime is guilty of 'conspiracy'
Unless they changed the legal definition since I was a Ca. cop.
It''s a homicide for sure. A murder? I wouldn't say that just yet.