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Spain's Defense Ministry says a Spanish missionary priest who has tested positive for the Ebola virus has landed in Spain on a flight from Liberia.
Did the NIH play a role in getting the experimental therapy to the two U.S. patients in Liberia?
This experimental treatment was arranged privately by Samaritan's Purse, the private humanitarian organization, which employed one of the Americans who contracted the virus in Liberia. Samaritan's Purse contacted the Centers for Disease Control and Prevention (CDC), who referred them to the National Institutes of Health (NIH). NIH was able to provide the organization with the appropriate contacts at the private company developing this treatment. The NIH was not involved with procuring, transporting, approving, or administering the experimental treatments.
Is ZMapp a vaccine?
No. ZMapp is being developed as a therapeutic product for treatment of people infected with Ebola virus, but not to prevent infection in the same manner as a vaccine. The best way to prevent infection currently is with stringent infection control measures.
There are currently no FDA approved vaccines for Ebola. The NIH's National Institute of Allergy and Infectious Diseases is working on developing an Ebola vaccine. NIH recently announced they are expediting their work, and aiming to launch phase 1 clinical trials of an Ebola vaccine in the fall. NIH is also supporting the Crucell biopharmaceutical company in its development of an Ebola/Marburg vaccine as well as Profectus Biosciences in its development of an Ebola vaccine.
Is the U.S. government involved in the development of ZMapp?
Two other companies, Tekmira and Biocryst Pharmaceuticals, receive funding from the Department of Defense's Defense Threat Reduction Agency and have therapeutic candidates for Ebola in early development. The Department of Defense is working with a company called Newlink to develop an Ebola vaccine candidate. BioCryst, with NIH support, is working to develop an antiviral drug to treat Ebola virus that is expected to begin Phase 1 testing later this year.
Since inception, Tekmira has fostered collaborations and partnerships with leading companies in the RNAi field, including Alnylam Pharmaceuticals, Inc., Bristol-Myers Squibb Company, Merck & Co. Inc., Takeda Pharmaceutical Company, the United States Government's Transformational Medical Technologies (TMT) Program, Monsanto, and other undisclosed pharmaceutical and biotechnology companies.
In 2014, Tekmira signed an Option Agreement with Monsanto, permitting Monsanto to obtain a license to use Tekmira's proprietary delivery technology. The companies' agreement and research collaboration will focus on the development of new innovative biological solutions for farmers, which have the potential to provide new options for sustainable pest, virus and weed control. The potential value of the transaction could reach up to $86.2 million following the successful completion of milestones.
For decades biotech companies have produced such antibodies by growing genetically engineered mouse cells in enormous metal bioreactors. But in the case of the new Ebola treatment ZMapp, developed by Mapp Pharmaceuticals, the antibodies were produced in tobacco plants at Kentucky Bioprocessing, a unit of tobacco giant Reynolds American.
The tobacco-plant-produced monoclonals have been dubbed “plantibodies.”
“Tobacco makes for a good vehicle to express the antibodies because it is inexpensive and it can produce a lot,” said Erica Ollmann Saphire, a professor at The Scripps Research Institute and a prominent researcher in viral hemorrhagic fever diseases like Ebola. “It is grown in a greenhouse and you can manufacture kilograms of the materials. It is much less expensive than cell culture.”
In the standard method of genetic engineering, DNA is slipped into bacteria, and the microbes produce a protein that can be used to combat a disease.
Burial ceremonies in which mourners have direct contact with the body of the deceased person can also play a role in the transmission of Ebola.
Persons who have died of Ebola must be handled using strong protective clothing and gloves, and be buried immediately.
People are infectious as long as their blood and secretions contain the virus. For this reason, infected patients receive close monitoring from medical professionals and receive laboratory tests to ensure the virus is no longer circulating in their systems before they return home.
When the medical professionals determine it is okay for the patient to return home, they are no longer infectious and cannot infect anyone else in their communities.
Men who have recovered from the illness can still spread the virus to their partner through their semen for up to 7 weeks after recovery. For this reason, it is important for men to avoid sexual intercourse for at least 7 weeks after recovery or to wear condoms if having sexual intercourse during 7 weeks after recovery.
I'm sorry but that doesn't sound like a fact and I have not seen any information that states that in any of the dozen or so sites I've looked at that are supplying information on Ebola. Granted there are not a lot of sites dedicated to Ebola. I disregard blogs and even some news outlets and have concentrated my research efforts on health agencies and medical study sites. I hate having this phrase thrown at me so I'm a bit reluctant to say it myself so instead of shouting "GOT A SOURCE FOR THAT?" I'm going to ask you to just point me in the right direction. Thanks.
originally posted by: Snarl
Fact: a host is still contagious, for as long as two months after the virus has run its course, providing s/he survived the infection.
I'm sorry but that doesn't sound like a fact and I have not seen any information that states that in any of the dozen or so sites I've looked at that are supplying information on Ebola.
The Ebola virus can be up to 14,000 nanometres in length. That’s surprisingly large for a virus, but still too small to see with the naked eye. But if it were the size of a car, it could kill you if dropped on you from even a modest height!
Ebola is not the deadliest virus known to mankind in terms of number of overall deaths caused, but if it ends up causing more deaths than the deadliest virus known to mankind, then Ebola would be the deadliest virus known to mankind!
Some have reported that the Ebola outbreak could be much worse than is believed due to the full number of cases not being reported. However, if you’re basing conclusions on information we don’t have, there’s no limit to how many people might have Ebola. You, the one reading this, could have it right now! We don’t have any information to suggest otherwise, so who’s to know?
Vox recently reported that if the supercontinent Pangaea were to reform today, the US would border the Ebola epidemic locations, which would obviously make it easier for the virus to spread. While this may be true, we can take comfort from the fact that, if all the continents on Earth were to suddenly rearrange themselves, the resultant geological, environmental and societal devastation would achieve apocalyptic levels several times over, so a localised (if deadly) virus would be way down on the list of concerns for whatever is left of the human race at this point.
Ebola is believed to be carried by fruit bats, and the wastes or meat from such bats is believed to have caused the current outbreak. Bats are common throughout the world, and some are believed to be vampires in disguise, and vampires can sneak into your bedroom and drink your blood as you sleep. If the vampire that bites you transforms into an Ebola-carrying bat, then this would be a sure-fire way of contracting Ebola. You can’t be too careful, after all.
f you laid out all the recorded victims of Ebola end-to-end, the end result would be so horrific as to defy description, and you’d probably be arrested and/or placed in a high-security psychiatric facility for having done such a grotesque thing.
Some have claimed that homeopathy can be used to treat Ebola, but there is no scientific evidence to support such a claim. This still applies if you replace “Ebola” with TB or Aids or influenza or bronchitis or Sars or bird flu or swine flu or rhinovirus or Legionnaires’ disease or Parkinson’s or Huntington’s or gout or athletes foot or gum disease or gallstones or ME or cerebral palsy or kidney stones or heatstroke or arrhythmia or hypotension or hypertension or basically anything that is inconsiderate enough to be an actual illness with a biological mechanism.
The current outbreak is caused by a variant of Zaire Ebolavirus with 97% sequence identity to strains isolated from the DRC and Gabon, suggesting a parallel evolution of this virus in the affected area as opposed to introduction from these endemic areas.
originally posted by: AutumnWitch657
It's Ebola Zaire. It's been identified by several health agencies. a reply to: Zebra501