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High-dose vitamin C can boost the cancer-killing effect of chemotherapy in the lab and mice, research suggests.
Given by injection, it could potentially be a safe, effective and low-cost treatment for ovarian and other cancers, say US scientists.
Reporting in Science Translational Medicine, they call for large-scale government clinical trials.
Pharmaceutical companies are unlikely to run trials, as vitamins cannot be patented.
Vitamin C has long been used as an alternative therapy for cancer.
In the 1970s, chemist Linus Pauling reported that vitamin C given intravenously was effective in treating cancer.
However, clinical trials of vitamin C given by mouth failed to replicate the effect, and research was abandoned.
It is now known that the human body quickly excretes vitamin C when it is taken by mouth.
However, scientists at the University of Kansas say that when given by injection vitamin C is absorbed into the body, and can kill cancer cells without harming normal ones.
The researchers injected vitamin C into human ovarian cancer cells in the lab, into mice, and into patients with advanced ovarian cancer.
They found ovarian cancer cells were sensitive to vitamin C treatment, but normal cells were unharmed.
The treatment worked in tandem with standard chemotherapy drugs to slow tumour growth in mouse studies. Meanwhile, a small group of patients reported fewer side-effects when given vitamin C alongside chemotherapy.
One potential hurdle is that pharmaceutical companies are unlikely to fund trials of intravenous vitamin C because there is no ability to patent natural products.
"Because vitamin C has no patent potential, its development will not be supported by pharmaceutical companies," said lead researcher Qi Chen.
As for this use, is the medical profession afraid to prove Linus Pauling right? Of course it is. Thieves and crooks, in it for the money and not for the medicine.
On most Vitamin C threads I get around to mentioning, because actually few people know it when imnho it should be shouted from rooftops at regular intervals, that human's lack of vitamin C is a major genetic disease.
Thebel
Broccoli is one of best Vitamin C sources. 156 grams (1 cup) has 134,9% of recommended daily value.
Best Vitamin source is Rosehip: 100 grams of Rosehip has 710% of recommended daily value of C vitamin. It has 60 times more C vitamin than Citrus fruits.
yorkshirelad
Before folks go of on the usual suppression rants. On the other side of the coin is the research that show that anti-oxidants (such as vitamin C and E) can promote cancer growth. The reason being that the anti oxidants de-activate a gene p53 whose job it is to destroy cells with defective genes ie cancer cells.
Aleister
Thebel
Broccoli is one of best Vitamin C sources. 156 grams (1 cup) has 134,9% of recommended daily value.
Best Vitamin source is Rosehip: 100 grams of Rosehip has 710% of recommended daily value of C vitamin. It has 60 times more C vitamin than Citrus fruits.
EEK. No, the RDV in the U.S. is dictated by the citrus industry, and is so low all it does is keep scurvy away (but not by much). The recommended daily amount in the U.S. is not only a joke, but is the punch line (hitting you in the gut). Our bodies inability to make ascorbic acid (nicknamed 'vitamin c'), a huge genetic disease that all humans and other primates have (except for lemurs), can only be nudged half an inch away with the criminally low recommended daily value.
Antigod
Aleister
Thebel
Broccoli is one of best Vitamin C sources. 156 grams (1 cup) has 134,9% of recommended daily value.
Best Vitamin source is Rosehip: 100 grams of Rosehip has 710% of recommended daily value of C vitamin. It has 60 times more C vitamin than Citrus fruits.
EEK. No, the RDV in the U.S. is dictated by the citrus industry, and is so low all it does is keep scurvy away (but not by much). The recommended daily amount in the U.S. is not only a joke, but is the punch line (hitting you in the gut). Our bodies inability to make ascorbic acid (nicknamed 'vitamin c'), a huge genetic disease that all humans and other primates have (except for lemurs), can only be nudged half an inch away with the criminally low recommended daily value.
It's not a disease, we just lost the ability to eat it as we gained so much from the vegetation we ate making it wasn't necessary. Since everyone lost the ability to manufacture it, it must have been a metabloically wasteful process to have been ditched like that.