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originally posted by: flice
This is important.
The study followed the subjects over an 8 month period.
Their findings, yet to be peer reviewed, are than because the anti bodies after infection does not only ttarget the spike protein, but also other parts, it is nlt only very durable anti bodies, which plateau after 8 months, but enough to be woken again.
[snipped]
Medrxiv
originally posted by: infolurker
Let's see.
The vaccine produces spike protein to train your immune response.
Having the virus trains your body to have an immune response to the whole virus. And of course, the virus produces the same spike proteins as the vaccine.
I wonder which is better
Do masks work this week?
originally posted by: infolurker
Having the virus trains your body to have an immune response to the whole virus. And of course, the virus produces the same spike proteins as the vaccine.
originally posted by: 1947boomer
OK, I read the article. It doesn't suggest anything like what your OP states. The study began in Spring of 2020, before any vaccines were ever released. It showed that a COVID infection produces antibodies that last at least 8 months and probably longer, actually. That's not a surprise. The study made no comparison whatsoever with the efficacy or longevity of vaccination produced antibodies, because it would have been physically impossible to do so. Apparently, you made up the suggestion that infection produces "better" protection than vaccines on the basis of no evidence.
OK, I read the article. It doesn't suggest anything like what your OP states. The study began in Spring of 2020, before any vaccines were ever released.
originally posted by: Xtrozero
originally posted by: infolurker
Let's see.
The vaccine produces spike protein to train your immune response.
Having the virus trains your body to have an immune response to the whole virus. And of course, the virus produces the same spike proteins as the vaccine.
I wonder which is better
Do masks work this week?
As we move into variants it seems either might work about the same as the body triggers on the protein of the varant, but many say the vaccine has an edge with variants compared with just antibodies from the virus. I think the key is not to get the virus or any vartant in the form of a nuevo virus, and to have the body already standing by on the first go with the virus...right?
originally posted by: flice
Noone says that... link to proof and their source.
Otherwise you are just divulging bull# for others who also dont care to go into the studies, to generate an unfunded opinion from.
In their new study, published in the journal Science Translational Medicine, Bloom, Greaney, and colleagues looked again to the thousands of possible RBD variants to understand how antibodies might be expected to hit their targets there [1]. This time, they wanted to explore any differences between RBD-directed antibodies based on how they were acquired.
Again, they turned to deep mutational scanning. First, they created libraries of all 3,800 possible RBD single amino acid mutants and exposed the libraries to samples taken from vaccinated individuals and unvaccinated individuals who’d been previously infected. All vaccinated individuals had received two doses of the Moderna mRNA vaccine. This vaccine works by prompting a person’s cells to produce the spike protein, thereby launching an immune response and the production of antibodies.
By closely examining the results, the researchers uncovered important differences between acquired immunity in people who’d been vaccinated and unvaccinated people who’d been previously infected with SARS-CoV-2. Specifically, antibodies elicited by the mRNA vaccine were more focused to the RBD compared to antibodies elicited by an infection, which more often targeted other portions of the spike protein. Importantly, the vaccine-elicited antibodies targeted a broader range of places on the RBD than those elicited by natural infection.
These findings suggest that natural immunity and vaccine-generated immunity to SARS-CoV-2 will differ in how they recognize new viral variants. What’s more, antibodies acquired with the help of a vaccine may be more likely to target new SARS-CoV-2 variants potently, even when the variants carry new mutations in the RBD.
It’s not entirely clear why these differences in vaccine- and infection-elicited antibody responses exist. In both cases, RBD-directed antibodies are acquired from the immune system’s recognition and response to viral spike proteins. The Seattle team suggests these differences may arise because the vaccine presents the viral protein in slightly different conformations.
Also, it’s possible that mRNA delivery may change the way antigens are presented to the immune system, leading to differences in the antibodies that get produced. A third difference is that natural infection only exposes the body to the virus in the respiratory tract (unless the illness is very severe), while the vaccine is delivered to muscle, where the immune system may have an even better chance of seeing it and responding vigorously.
originally posted by: Xtrozero
originally posted by: flice
Noone says that... link to proof and their source.
Otherwise you are just divulging bull# for others who also dont care to go into the studies, to generate an unfunded opinion from.
It took me like 20 seconds to find this below and wasn't my main point which you didn't address at all "I think the key is not to get the virus or any vartant in the form of a nuevo virus, and to have the body already standing by on the first go with the virus...right?"
In their new study, published in the journal Science Translational Medicine, Bloom, Greaney, and colleagues looked again to the thousands of possible RBD variants to understand how antibodies might be expected to hit their targets there [1]. This time, they wanted to explore any differences between RBD-directed antibodies based on how they were acquired.
Again, they turned to deep mutational scanning. First, they created libraries of all 3,800 possible RBD single amino acid mutants and exposed the libraries to samples taken from vaccinated individuals and unvaccinated individuals who’d been previously infected. All vaccinated individuals had received two doses of the Moderna mRNA vaccine. This vaccine works by prompting a person’s cells to produce the spike protein, thereby launching an immune response and the production of antibodies.
By closely examining the results, the researchers uncovered important differences between acquired immunity in people who’d been vaccinated and unvaccinated people who’d been previously infected with SARS-CoV-2. Specifically, antibodies elicited by the mRNA vaccine were more focused to the RBD compared to antibodies elicited by an infection, which more often targeted other portions of the spike protein. Importantly, the vaccine-elicited antibodies targeted a broader range of places on the RBD than those elicited by natural infection.
These findings suggest that natural immunity and vaccine-generated immunity to SARS-CoV-2 will differ in how they recognize new viral variants. What’s more, antibodies acquired with the help of a vaccine may be more likely to target new SARS-CoV-2 variants potently, even when the variants carry new mutations in the RBD.
It’s not entirely clear why these differences in vaccine- and infection-elicited antibody responses exist. In both cases, RBD-directed antibodies are acquired from the immune system’s recognition and response to viral spike proteins. The Seattle team suggests these differences may arise because the vaccine presents the viral protein in slightly different conformations.
Also, it’s possible that mRNA delivery may change the way antigens are presented to the immune system, leading to differences in the antibodies that get produced. A third difference is that natural infection only exposes the body to the virus in the respiratory tract (unless the illness is very severe), while the vaccine is delivered to muscle, where the immune system may have an even better chance of seeing it and responding vigorously.
Doc