posted on Dec, 3 2012 @ 10:16 AM
I have yet to make my own first batch of Liposomal Vit C, but I intend to.
Firstly, thank you Loam for posting your findings. I find them to be well thought through and informative and I'm sorry to see some misguided
antagonism being directed towards you, I suppose it's an occupational hazard posting in a forum like this
For those of you who make your own lipo vit C, I came across this paper on Liposomal Encapsulation which my contain some useful information.
Encapsulating bioactive agents into Liposomes
I became curious as to why everyone is so adamant about using an ultrasonic cleaner to encapsulate the ascorbic acid. I looked for a reasonable
explanation but was unable to find one short of "don't let anyone tell you it can be done any other way" with no reason to back it up.
This paper seems to indicate that on the scale of it, the ultrasonic is one of the least efficient methods of encapsulation with a trapping efficiency
of between 1-5%; certainly no better than mechanical mixing which has a trapping efficiency of between 1-8.5%
The most compelling findings seem to be using a freeze-thaw method of encapsulation.
More recently, studies have shown the multiple freeze-thaw steps completed directly on MLV dispersions induce a remarkable morphological change in the
liposomes and results in a IO-fold or greater increase in the aqueous trapped volumes . Trapping efficiencies as high as 88% for these systems can
be achieved by utilizing high lipid concentrations, although entrapped solute/lipid ratios appear to decrease above 100 mg lipid/ml, presumably due to
a lack of avail- able aqueous media.
I for one will try mixing a blend of ascorbic acid, non gmo soy lecithin and sodium bicarbinate (to keep the mixture closer to a neutral pH of around
7.3, the natural pH level of blood) using a simple mechanical blender, freezing and thawing. I will be conservative with my dosing considering the
potential for higher bioavailability!
As this is the latest thread on the subject I thought it would be better to post here than the other, already overpopulated thread. Hope you find it