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More recently, studies have shown the multiple freeze-thaw steps completed directly on MLV dispersions induce a remarkable morphological change in the liposomes and results in a IO-fold or greater increase in the aqueous trapped volumes . Trapping efficiencies as high as 88% for these systems can be achieved by utilizing high lipid concentrations, although entrapped solute/lipid ratios appear to decrease above 100 mg lipid/ml, presumably due to a lack of avail- able aqueous media.
Originally posted by loam
Ok, so apparently this consequence of mega dose Vitamin C is well known.
I found this paper from the BIO-COMMUNICATIONS RESEARCH INSTITUTE on something called the The Riordan IVC Protocol 2009: Intravenous Ascorbate (IVC) as a Chemotherapeutic and Biologic Response Modifier.
It immediately begins with:
There is slight interaction with pancreatic beta cells, it seems. It looks like some of the DHAA can enter via GLUT2 receptor into beta cells and thus reduce the concentration of glucose in the cell, which delays insulin secretion (there are other explanations too)
I don't think its a big problem (or problem at all). Vitamin C can probably also reduce absorption of dietary sugar if taken with meal so its a good thing and there are also studies showing protective effect of AA.