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The encounter was primarily designed for Cassini's ion and neutral mass spectrometer instrument, which sampled the composition of Enceladus's south polar plume.
Other instruments, including the Cassini plasma spectrometer and composite infrared spectrometer, also took measurements.
Before the closest approach to Enceladus, Cassini's onboard cameras captured images of the geysers, which contain organic compounds along with the ice and vapour.
"In the end, it's the most promising place I know of for an astrobiology search. We don't even need to go scratching around on the surface. We can fly through the plume and sample it. Or we can land on the surface, look up and stick our tongues out."
"Cassini has flown several times now through this spray and has tasted it. And we have found that aside from water and organic material, there is salt in the icy particles. The salinity is the same as that of Earth's oceans," said Dr Carolyn Porco, head of the imaging team on Cassini.
The habitable zone on Enceladus might be comparatively easy to access by future robotic space missions. Dr Porco added: "It's erupting out into space where we can sample it. It sounds crazy but it could be snowing microbes on the surface of this little world .
"The kind of ecologies Enceladus might harbour could be like those deep within our own planet," Dr Porco said in an interview with Nasa's science website
Dramatic plumes, both large and small, spray water ice from many locations near the south pole of Saturn's moon Enceladus. More than 30 individual jets of different sizes can be seen in this image