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A group of researchers in Denmark is working on creating something entirely new on this planet – lifeforms that contain an improved version of the double-helix DNA. They are, for all intents and purposes, seeking to create stable, triple-helix deoxyribonucleic acid.
Since the acid was first discovered, experts have known that it features two strands, which dance around each other and form a distinctive, double-helix structure. All complex organisms contain DNA, and all of them feature variations of this configuration.
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According to the scientists these PNA strands would help cure, or eradicate many illnesses by blocking the genes in the DNA strand which can cause such illnesses, including particular forms of cancer.
April 27, 2010
NextGen Triple-Helix DNA -It Could be Scary!
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Gene Instead of a single PNA strand joining into the genetic party, two PNAs would muscle out one of the existing strands and create a region of two-thirds artificial triple-tagged helix. The displaced DNA would hang loose outside this region, forming a "p-loop" which has since been found to speed up replication of the structure. Also, the PNA-DNA bonds are stronger than the originals.
To recap: you have artificial cyber-genetics with capabilities beyond those of weak organics, they're stronger, and they can replicate faster. It's clear that this entire branch of science has escaped from a movie somehow, a conclusion strengthened by the fact that the PNA has a ridiculous weakness: water. Yes, just like Signs. No, we don't think it's on purpose.
Inside a squishy organic creature isn't a great place for chemicals that don't like water, and any PNA in a living organism is rapidly excreted - but not too rapidly for it to have effects. PNA has already been used to cure muscular dystrophy in lab animals, meaning that even without a chemical raincoat (which scientists are already working on) it's a powerful tool for controlling the very code of creation.
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Triple Helix: Designing a New Molecule of Life
Peptide nucleic acid (gold) readily enters DNAs major groove to form triple-stranded and other structures with DNA, allowing it to modify the activity of genes in new ways. Jean-Francois Podevin Key Concepts A synthetic molecule called peptide nucleic acid (PNA) combines the information-storage properties of DNA with the chemical stability of a proteinlike backbone. Drugs based on PNA would achieve therapeutic effects by binding to specific base sequences of DNA or RNA, repressing or promoting the corresponding gene. Some researchers working to construct artificial life-forms out of mixtures of chemicals are also considering PNA as a useful...
Triple Helix: Designing a New Molecule of Life
Peptide nucleic acid, a synthetic hybrid of protein and DNA, could form the basis of a new class of drugs—and of artificial life unlike anything found in nature
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A synthetic molecule called peptide nucleic acid (PNA) combines the information-storage properties of DNA with the chemical stability of a proteinlike backbone.
Drugs based on PNA would achieve therapeutic effects by binding to specific base sequences of DNA or RNA, repressing or promoting the corresponding gene.
Some researchers working to construct artificial life-forms out of mixtures of chemicals are also considering PNA as a useful ingredient for their designs.
PNA-like molecules may have served as primordial genetic material at the origin of life.