(Ethical or Unethical) Placebo testing new cancer drugs on terminally ill patients

Here I will take a quote from an article that I read.



So basically they take a group of people terminally ill with cancer. They have a drug they think may extend the patients life or end the patients cancer. Then a few of the group will not receive the real drug just a sugar pill so they can test the effects of the drugs vs. the placebo effect. They need a control group basically. Human Guinea pigs in other words.

Now to be fair this method of testing drugs does get the drug to market faster. The question is whether or not it is moral to knowingly let someone perish when there are drugs that could be helping them. Put a family member of yours in the situation. You would want anything in the world to help them.

Heres another article on the ethics of testing drugs on people. This isn't just in cacer patients it also goes on with other terminally ill patients such as aids. I personally feel this is terrible.



[edit on 9-6-2004 by Hoppinmad1]

I think it is important to point out that subjects in a clinical trial involving a placebo control group are required to understand the risks associate via the process of informed consent


Source: ClinicalTrials.gov

Using terminally ill patients to test drugs on is not one of the more pleasent concepts, but the drugs have to be tested somehow. Seeings how these people are bound to die soon anyways...why not?

As long as there is no discrimination in who is in the placebo group and who is the control group I see no problem with this. The only point in which it becomes an issue is if the tested drug turns out to be a miracle cure and those who got the drug benefitted and those in placebo group were harmed. Since that is not likely and since they patients know they have a 50/50 shot at being in the placebo group when they signed up, there's not really anything that wrong here. I didn't get the feeling from your article that anyone was being mislead.

I feel that these people are desperate for anything to help them. Is it wrong for scientists to take advantage of that. Is it ethical for some scientist to knowingly choose who is going to die and who may live an extra few months. This is a hard subject to decide on. I can't really make up my mind. Knowing others will benefit is the drug works because it can go to market faster, but then knowing others could have lived if they had the real medicine.

The patients willingly sign up knowing that they have a chance of being given nothing but a placebo. Nobody's duping anybody. There is nothing unethical about this.

In a double blind study the doctors do not know who is getting the drug and who is getting the placebo. I have heard of studies where the drug seemed to be working well and they then gave it to everyone in the test.

Agreed- and sometimes, dontcha know, the placebo effect works wonders. It's been this way for quite some time- the question of medical testing, at least. Trust me, the alternative isn't quite so hot either. With the placebo drug, one can measure the effects as compared to the psychosematic effects.

DE

My mother was diagnosed with 4th stage colon cancer. There was no hope for her. She willingly signed up for the first clinical trials on the drug that is now being touted as a potential "wonder drug." We knew that she would not get better with coventional chemotherapy and we also understood that this drug would, most likely, not help her significantly. But, there was an outside chance AND she felt strongly, as we all did, that at least her illness might benefit others someday.
The drug, she was given, must have been the real thing. It did reduce the tumor size, but not enough to keep her in the program. She then underwent conventional chemo and died soon afterwards.
I don't feel she was a guinea pig or that anythign unethical was done. WE knew the risks and she made a very informed consent. I rest easier knowing that, in some small way, the ravages of her illness might have helped others someday in the future.
joey

Let’s understand that to be in a trial you have to consent and be willing.

If I become sick with a terminal illness I will go into clinical trials, some of this trials have extended peoples life.

This is not a matter of right or wrong but of personal choice.