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Rarely, patients taking bisphosphonates have reported serious jaw problems associated with delayed healing and infection, often following dental procedures such as tooth extraction. If you experience jaw problems, please contact your healthcare provider and dentist.
Magnesium supplementation and osteoporosis.
Sojka JE, Weaver CM. Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47904, USA.
Among other things, magnesium regulates active calcium transport. As a result, there has been a growing interest in the role of magnesium (Mg) in bone metabolism. A group of menopausal women were given magnesium hydroxide to assess the effects of magnesium on bone density. At the end of the 2-year study, magnesium therapy appears to have prevented fractures and resulted in a significant increase in bone density.
In a retrospective study from the University of Southern California (USC), four percent of female patients with a history of using the osteoporosis drug alendronate (Fosamax®) developed osteonecrosis of the jaw (ONJ). The study, published in the January 2009 Journal of the American Dental Association,
Overall, the USC study was a relatively small, retrospective evaluation, and the findings do not provide definitive evidence on either the prevalence of ONJ or risk factors for developing ONJ in individuals with a history of oral alendronate use. However, the study findings require close consideration because they suggest that the prevalence of ONJ may be much higher than previously reported among patients who have undergone invasive dental procedures (e.g., tooth extraction) or who wear dentures, and have previously or are currently using oral alendronate (Fosamax)
Prolonged Magnesium Deficiency Causes Osteoporosis in the Rat
G. Stendig-Lindberg, MD, LRCPI, W. Koeller, Mech.Ing, A. Bauer, MD and P.M. Rob, MD
Dept Physiol and Pharmacol, Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, ISRAEL, Dept of Orthopedics and Dept of Dialysis, University Hospital, University of Luebeck, Luebeck, GERMANY
Conclusion: Experimentally induced prolonged Mg deficiency causes osteoporosis in rats.
Magnesium may reduce risk of diabetes
Mineral appears to have effect on action of insulin
By Karen Collins, R.D.
updated 6:25 p.m. ET May 7, 2004
In a study of over 39,000 women, those who were getting the most magnesium had an 11 percent lower risk of developing diabetes six years later than those who got the least. Among overweight women the magnesium impact was even stronger: Risk fell more than 20 percent.
High fiber and magnesium may cut diabetes risk
NEW YORK (Reuters Health) - High levels of cereal fiber and magnesium are associated with a reduced risk of type 2 diabetes mellitus, according to a report in the Archives of Internal Medicine.
The findings stem from an analysis performed by Dr. Matthias B. Schulze and colleagues from the German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal. The study involved over 25,000 adults, between 35 and 65 years of age, who were followed from 1994 to 2005 for diabetes. A food-frequency questionnaire was used to assess the participants for the amounts of dietary fiber and magnesium.
During follow-up, 844 subjects developed type 2 diabetes, the report indicates. Compared with the subjects with the lowest cereal fiber intake, those with the highest intake had a 28-percent reduction in diabetes risk.