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Scientists say they have found physical evidence of brain differences which may drive "thrill-seekers" to act impulsively or dangerously.
A small study from Vanderbilt University in the US found the biggest "risk-takers" processed a brain "reward" chemical dopamine differently.
Scans spotted fewer "receptors" for the chemical on the cells which make it.
The Journal of Neuroscience study could help explain why some are vulnerable to drug abuse and other addictions.
Originally posted by Anti - Government
Are they trying to say that thrill seakers have something wrong with them by saying theat they are more lilkely to drug abuse because thats just stupidor that they are different or just trying to label them either way So What
Midbrain Dopamine Receptor Availability Is Inversely Associated with Novelty-Seeking Traits in Humans
David H. Zald,1,2 Ronald L. Cowan,2,3 Patrizia Riccardi,4 Ronald M. Baldwin,3 M. Sib Ansari,3 Rui Li,3 Evan S. Shelby,1 Clarence E. Smith,3 Maureen McHugo,1 and Robert M. Kessler3
Departments of 1Psychology, 2Psychiatry, and 3Radiological Sciences, Vanderbilt University Nashville, Tennessee 37240, and 4Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, New York 10461
Correspondence should be addressed to Dr. David H. Zald, Department of Psychology, PMB 407817, 2301 Vanderbilt Place, Nashville, TN 37240. Email: [email protected]
Novelty-seeking personality traits are a major risk factor for the development of drug abuse and other unsafe behaviors. Rodent models of temperament indicate that high novelty responding is associated with decreased inhibitory autoreceptor control of midbrain dopamine neurons. It has been speculated that individual differences in dopamine functioning also underlie the personality trait of novelty seeking in humans. However, differences in the dopamine system of rodents and humans, as well as the methods for assessing novelty responding/seeking across species leave unclear to what extent the animal models inform our understanding of human personality. In the present study we examined the correlation between novelty-seeking traits in humans and D2-like (D2/D3) receptor availability in the substantia nigra/ventral tegmental area. Based on the rodent literature we predicted that novelty seeking would be characterized by lowered levels of D2-like (auto)receptor availability in the midbrain. Thirty-four healthy adults (18 men, 16 women) completed the Tridimensional Personality Questionnaire-Novelty-Seeking Scale and PET scanning with the D2/D3 ligand [18F]fallypride. Novelty-Seeking personality traits were inversely associated with D2-like receptor availability in the ventral midbrain, an effect that remained significant after controlling for age. We speculate that the lower midbrain (auto)receptor availability seen in high novelty seekers leads to accentuated dopaminergic responses to novelty and other conditions that induce dopamine release.
Originally posted by kettlebellysmith
I know quite a few adrenalin junkies, and used to be one myself. It's not the risk. It's the high that comes after the risk.
Originally posted by Anti - Government
Are they trying to say that thrill seakers have something wrong with them by saying theat they are more lilkely to drug abuse because thats just stupidor that they are different or just trying to label them either way So What