Yes with a but.............
The Buff has shown itself to be an adaptable airframe for just about anything. If money is no object then it may be able to do so however.....
Im not sure the weight of the COIL laser and its related equipment would be a fit. While big, the BUFF is fairly narrow when compaired to a 747-400F
and may not have the payload capacity for it. Nor could you retrofit the turret ala the ABL because fo the cockpit. In the -400 its mounted high.
Now a solid state laser in the gigwatt range that placed in a turret on the top or bottom of the airframe may do the trick. However, i suspect that
you would have to convert the 8 engines to 4 CMF's to be able to generate the power needed for this.



