Neural engineering, particularly in the form brain-computer interfaces, is not uncommon in the BattleTech universe. Its principal application is the "neurohelmet", a device used in nearly all BattleMechs that gives the 'Mech's pilot the ability to control some aspects of the machine's behavior simply by thought. The neurohelmet provides balance information to the 'Mech to assist in walking and maneuvering. It also acts as a security device, limiting access to authorized users via alpha brain wave pattern recognition (many BattleMechs mentioned in the novels also incorporate more conventional security measures such as voice-recognition and personalised codes). Enhanced Imaging (EI) technology developed by the Clans uses a subdermal skein of wiring to grant better control over a machine.

More advanced neural engineering technologies include the experimental Direct Neural Interface (DNI), a system that provides a MechWarrior fuller mental control over a 'Mech than offered by a standard neurohelmet.[14] The system's potential for serious neurological damage to the MechWarrior prevented the technology from advancing beyond the prototype stage, though Vehicular Direct Neural Interface (VDNI) was later successfully deployed by the Word of Blake to create the "cyber-soldiers" of the Manei Domini.

Other applications of bionics range from prosthetic limbs, such as the hand of Justin Xiang,[14] to elective implants intended to improve strength or enhance the senses.[15] An extreme example of bionic augmentation was Captain-General Gerald Marik who in 2667 received extensive implants following a life-threatening injury.[16]