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Tannic acid compositions for treating cancer..
...The pharmaceutical composition of the invention is advantageously used to treat any cancer condition. Thus the invention preferably provides a method of treating cancers including, but not limited to bladder, breast, kidney, leukemia, myeloma, liposarcoma, lymphoma, colon, penis, tongue, prostate and uterus cancers...….In sum, the invention provides a pharmaceutical composition including tannic acid and tannin complexes, and a method of treating cancer with tannic acid and tannin complexes which shows effective results in the treatment of cancer…
52 year old female, Carcinoma of the uterus. Surgery to remove the uterus was recommended and an operation planned. Upon opening patient, metastatic growth throughout internal organs was detected. Uterus was not removed and patient was classified terminal. Maximum therapy in accordance with the invention levels were administered for a period of one year. She was cured of the cancer throughout her body. Yearly checkups have confirmed no relapse.
67 year old female. Carcinoma of the uterus. Cancer was pervasive throughout organ. Radiation therapy was prescribed. She had such a violent reaction to the radiation that she refused further treatment. She underwent therapy in accordance with the invention at maximum dosage for a period of one year. No other treatments were applied. Semi-annual checkups reveal no relapse.
56 year old female. Colon Carcinoma. Experienced bowel blockage. Diverted passage of refuse but did not remove tumor. Tumor was so large that removal was not feasible. Surgery was performed to extend her life without hope of cure. Doctors opted to bypass chemotherapy and radiation therapy fearing results of extended therapy would be devastating. Therapy in accordance with the invention was administered at maximum level for a period of one year. Tumor disappeared and has not returned.
64 year old male. Carcinoma of penis. Surgery was performed to remove sexual organs (testes and penis). They found that the cancer metastasized and the patient was classified terminal. Therapy in accordance with the invention was administered at maximum levels immediately after surgery for one year. He has had no relapse and is cured of the cancer that was diagnosed after his surgery.
59 year old female. Carcinoma of the Breast with metastasis in both lungs and lymph nodes. Attending physician detected cancer initially in the lungs, but primary site was in the breast. Patient was classified terminal. Therapy in accordance with the invention was administered at maximum levels according to weight/height criteria for a period of one and one half year. At the end of therapy in accordance with the invention, the Doctor declared patient cured, and was impressed by the therapy. All check-ups have since been negative for cancer.
30 year old male. Hypernephroma (Cancer of Kidney). The Chief of Oncology and patient's relative were the attending physicians. Metastasis occurred in both the lungs and ribs (liver and brain were also suspected). Patient was given less than one month to live and was classified terminal. Therapy in accordance with the invention was administered at maximum levels according to weight/height criteria for a period of one year. After 20 days of therapy in accordance with the invention, regeneration of ribs had occurred, and after one month the patient had returned to normal daily activities. At three months, the therapy was discontinued due to matters beyond patient's control. The patient lived for two years after therapy, and never experienced any pain from the relapse
Originally posted by zooplancton
thank you for this thread. reading, printing and educating my mother whom fell victim last year to the ugly disease.
Originally posted by cams
Originally posted by toasted
That's a great list of books.
Toxicol Appl Pharmacol. 2010 Dec 29. [
Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity: Potential role of tannins in cancer chemotherapy.
Tikoo K, Sane MS, Gupta C.
Doxorubicin, an anthracycline antibiotic, is widely used in the treatment of various solid tumors including breast cancer. However, its use is limited due to a variety of toxicities including cardiotoxicity. The present study aimed to evaluate the effect of tannic acid, a PARG/PARP inhibitor and an antioxidant, on doxorubicin-induced cardiotoxicity in H9c2 embryonic rat heart myoblasts and its anti-cancer activity in MDA-MB-231 human breast cancer cells as well as in DMBA-induced mammary tumor animals. Doxorubicin-induced cardiotoxicity was assessed by measurement of heart weight, plasma LDH level and histopathology. Bcl-2, Bax, PARP-1 and p53 expression were examined by western blotting. Our results show that tannic acid prevents activation of PARP-1, reduces Bax and increases Bcl-2 expression in H9c2 cells, thus, preventing doxorubicin-induced cell death. Further, it reduces the cell viability of MDA-MB-231 breast cancer cells, increases p53 expression in mammary tumors and shows maximum tumor volume reduction, suggesting that tannic acid potentiates the anti-cancer activity of doxorubicin.
Copyright Â© 2010. Published by Elsevier Inc.
PMID: 21194538 [PubMed - as supplied by publisher]
To the best of our knowledge, this is the first report which shows that tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity both in vitro (H9c2 and MDA-MB-231 cells) as well as in in vivo model of .