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Evolution of vertebrate fibrin formation and the process of its dissolution.
Doolittle RF, Spraggon G, Everse SJ.
Center for Molecular Genetics, University of California at San Diego, La Jolla 92093-0634, USA.
The thrombin-catalysed conversion of fibrinogen into a fibrin gel is common to all extant vertebrates. Because fibrin formation is both temporary and risky, an effective scheme for fibrinolysis evolved concomitantly. In this regard, the fibrinogen molecule is well adapted both for network polymerization and for subsequent dismantling. The question is, has it always been so? It has long been known that the three non-identical chains that compose vertebrate fibrinogen are descended from a common ancestor, and the original molecule must have been either a homotrimer or a dimer thereof. Three-dimensional studies on core fragments of fibrinogen are revealing new insights about both fibrin formation and its destruction. These studies are also showing exactly what structural changes have accompanied changes in function for the various domains. Chief among these is the reversal of direction for the alpha chain after replacement of its C-terminal domain.
Proc Natl Acad Sci U S A. 2003 June 24; 100(13): 7527–7532.
Published online 2003 June 13. doi: 10.1073/pnas.0932632100.
Copyright © 2003, The National Academy of Sciences
Biochemistry
The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes
Yong Jiang and Russell F. Doolittle*
Originally posted by Kacen
Theres tons of evidence for evolution, however the scientific theory on it is it is random and not guided; that, I find hard to believe.
Originally posted by JesusisTruth
There are so many proofs of creation.
these signs dont just happen out of nowhere. How, absolutely how can any soul provided the things ive posted and the body parts and the miracles like the girl in my sig, not give this stuff a chance?
how can nothing make us smile and have these body parts that were made for specific reasons?
The bottocks
created for standing and sitting on a cushion.
The breast
Created for holding milk for women.
also the trinity is literally imaplnted on our bodies. Thats why we have 3 points in a triangular formation.
Finger nails.
made for scratching.
Teeth for chewing, hair for cold weather, all the senses.
Smiles and laughter.
Why does evolution have a personality?
Of corse you have to have some sense of deepness to see these things.
I just dont get it.
Originally posted by Heronumber0
So, yet again, as in every field of scientific research there is a huge question mark at the end. I say God is at the end of all question marks, in a similar way to the OP.