Icarus, since you can’t stay on the topic at hand without the insults let’s try to get back to some semblance of order and talk about the science
behind the medication. Here is a detailed description of the medication, its precautions, and the side effects:
Medical Science behind Mirapex
Mirapex (manufactured by Boehringer Ingelheim, and co-marketed by Pharmacia & Upjohns) contains the following Chemicals:
Pramipexole Dihydrochloride Monohydrate- only active ingredient in this product, as I have already described its effects on Dopamine levels and the
Basal Ganglia there is no need to go further with a description.
Mannitol- a naturally occuring polyol found in nature.
Corn starch- starch from the grain of the Maize plant, or obtained from the endosperm of corn kernels.
Colloidal silicon dioxide- poorly absorbed by the human body, used as an inactive ingredient.
Povidone- sometimes known as polyvinylpyrrolidone, it’s a common antiseptic used for disinfection in hospitals.
Magnesium Stearate- known as Magnesium Salt, it’s typically obtained from cattle, and used to lubricate molecules in medicine and food (Candy
contains the same thing).
These are the only chemicals in this medication, and that is not to say that this one active ingredient does not come without side effects. As I have
previously noted, Pramipexole works by binding to D1 and D3 receptors and restoring the function of the Dopamine receptors in the Basal Ganglia.
Because this medication interferes with the the part of the brain directly in care of the body’s movement you can clearly see it’s benefits to
people with movement disorders. However, in lieu of the fact that it controls dopamine levels in the brain it’s effect on the “pleasure” center
gives tremendous credence that it can play a role in gambling and sexual activity. I am not debating the fact that this medication causes these side
effects, because it clearly does, as has been noted by Boehringer Ingelheim in their original clinical trials with the medication. Taking any
medication is a risk that the patient assumes when they begin their regimen. It is also up to their primary care provider to discuss the implications
of taking medications that can cause these types of side effects.
The only thing we seem to be debating about is who actually manufacturers the drug. I have clearly shown and proven that Monsanto and their
subsidiary known as Pharmacia and Upjohns only play a role in the distribution and marketing of the medication, but that it is actually manufactured
by Boehringer Ingelheim who also co-markets the drug with the aforementioned company.
Monsanto, I will totally agree with you, is not what I would consider a supremely “ethical” company in what they manufacture, and there has been
quite a bit of debate about this very issue. In fact, Monsanto has been investigated by the Environmental Protection Agency on more than a few
occasions for possible contamination and pollution with its solvents. They have also been under inquiry and admitted to bribing Indonesian officials
to avoid environmental regulation, which as we all know is not very ethical in any sense of the word.
This being said, I don’t see where the conspiracy lies with their marketing of Mirapex, as I have listed all the ingredients found in this
medication, and it offers little evidence that there is anything lethal inside the drug. The FDA and the European Commission have both approved the
sale and release of Mirapex to the general public (including that the drug is manufactured by Boehringer Ingelheim), and you can read about its use
for RLS, on top of Parkinson’s disease, here at the bottom of the page:
Medscape: Approval for Mirapex
Or, directly from the FDA website indicating the date of release, manufacturers name, and all documentation concerning it’s release:
FDA Approval for Mirapex
[edit on 30-8-2007 by Jazzerman]