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The issue was a series of things, but the final straw was the keyboard not responding properly at all. For example I'd type one letter and 2-3 different letters would show up. Another letter and nothing would show. At first I thought it might just be the keyboard (easy fix with an external keyboard), but then other stuff started happening like programs starting unexpectedly, or closing, then the screen would go screwy and minimize to like 1" across, or blank out, or it would constantly sit there and minimize, maximize, disappear, etc. Definitely seemed to be the MB. No separate video card on that machine so it couldn't have been that.
I think the fan had failed a while back because I rarely heard it come on recently, and this could be part of it. Probably just cooked itself.