Researchers take important step forward in disabling cancer cells' defences

A study that opens new a new door for therapies for cancer ALS and others. This new study centered on cancer cells ability to fight back against treatments.

www.news-medical.net...
Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others.
Part of what makes cancer cells so devastating is their ability to fight back against treatments -- sometimes they work, sometimes they don't. But what if we could take away cancer cells' defences altogether?

Researchers from the University of Ottawa have taken an important step forward to doing just that. Dr. Kristin Baetz says the results of a three-way research collaboration could open doors to new therapeutics to treat a variety of diseases, including cancer.

Dr. Baetz at U of Ottawa studies stress granules. These are structures the body uses to protect the cells against environmental stressors. But cancer used this same system, this is why cancer can defend it's self against chemo.

Dr. Baetz is an associate professor at uOttawa's Faculty of Medicine and Director of the Ottawa Institute of Systems Biology. Her lab studies stress granules (SGs), which are structures produced by the body's cells to protect against environmental stressors. Unfortunately, SGs also help cancer cells defend themselves against chemotherapeutic treatments,

So the Dr. wants to see how to prevent the stress granules from protecting the cancer. Using yeast cells (they are similar to human cells) the Dr's lab has found a class of enzymes that regulate the stress granules formation. So they have found a way to decrease stress granules, and have therapeutics, now they have to see how it works on diseases.

"The first step in figuring out how to prevent this from happening is to understand how stress granules are formed and disassembled," explains Dr. Baetz, "and we now have key information."

Using yeast cells, her lab has identified a class of enzymes that play an active role in regulating SG formation. Deactivating this class of enzyme has a direct correlation to lowering SG levels.
"We've discovered one way to decrease stress granule formation, plus we have therapeutics -- so we're well positioned to explore how this strategy might work on diseases," Dr. Baetz says.

I pray to God that one day the demon that is cancer will be eliminated. This will be the next big leap for medicine. Fund cancer research!

Sounds like this is stuff we still need running normal to be healthy. Concerns with running such de-activators system wide thru the blood likely along the lines of when we run antibiotics the chems also take out all the good bacteria we need to exist (average human body has a good 10 pounds of good bacteria present [for all you germaphobes!]).

Perhaps they can hit an antidote holy grail that undoes the neutering work of the enzymes once the job is done, which I dont know it actually possible with antibiotics (its not like there only 3 types of bacteria in the body doing 3 single functions in 3 single body locations).

Or maybe they could approach this in 'crazy talk' terms, unlike with chemo they want to run thru your whole body, and inject the stuff into localized areas.

A not so 'fun fact' with cancer treatments, people often get pneumonia as part of the symptoms and treatments, thus requiring antibiotic shock treatments along side the 'chemo' (I hate that word; medicine is all just chemistry unless its surgery or radiation), so they wipe out the immune system while poisoning the entire body via the circulatory system.

a reply to: seasonal

Here's the actual paper, published in PLOS

Abstract

Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required for stress granule formation upon glucose deprivation but not heat stress. Further, the Tip60 complex, the human homolog of the NuA4 complex, is required for stress granule formation in cancer cell lines. Surprisingly, the impact of NuA4 on glucose-deprived stress granule formation is partially mediated through regulation of acetyl-CoA levels, which are elevated in NuA4 mutants. While elevated acetyl-CoA levels suppress the formation of glucose-deprived stress granules, decreased acetyl-CoA levels enhance stress granule formation upon glucose deprivation. Further our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1. Altogether this work establishes both NuA4 and the metabolite acetyl-CoA as critical signaling pathways regulating the formation of glucose-deprived stress granules.

a reply to: Kali74

Did you find any luck with turmeric, pubmed? Look up Korea, other sources of "nano-curcumin".

Pubmed knows more than people would realize. If you can find out specifics of the cancer lines you have then you punch those into pubmed with the word "apoptosis" to see what is known does work on any given cancer types. The big stumbling block normal people have with these 'curing cancer' discussions is in viewing "it" as a singular thing; the stumbling block cancer industry has (the industry, not the real research scientists) is in seemingly not realizing that any given type has multiple pathways that need to be attacked simultaneously, while they seem to like to sweep in with singular one size fits all approaches to organs and then bombard the entire body with whatever one or two poisons they decide is the best they've got for it. Imagine a combination lock that has 8 tumblers, and only getting 1 or 2 or 3 tumbler settings correct. Well that's how it usually ever goes so they go hardcore overkill with the ones they might have right.

www.ncbi.nlm.nih.gov...
www.alibaba.com...

Most of the people in the industry are sociopaths in my experience, by my estimations (it comes with the territory), but not all of them are. Regardless of that point, the industry tends to send people home once 'cured' without anything of a protocol to keep it from coming back (typically as the killer strain)... so keep that in mind.

And at any stage, simply OD'ing on random antioxidants can be as counterproductive as doing nothing. That's why you want to figure out the stuff that actually matters.

Depending on your situation, there's also the less known "Nano-Knife" treatment. One of its developers had been posting about it here in ATS.
www.abovetopsecret.com...
Developed in Aussieland, but they already had multiple units in operation here back during the time.

For radiation I saw a BBC documentary over in the UK they have an advanced method that does a sort of CNC method using a gyro arm that shoots thru a hundred micro beams from every direction that has minimal impact on the surrounding tissues while wrecking the focal point at the tumor zone. I saw it about 5 years ago I imagine they have units here in the US now.

You can take the protective slime off of cancer so our immune system can detect it with enzymes. Such as bromelain and papain and some of the animal proteinase enzymes. Or you can boost these enzyme productions by various ways. Also don't take antioxidants if you already have cancer, it shields detection by the immune system of rapidly growing cells. Antioxidants are a good thing to help to keep from getting cancer, but once you have it they are not good.

Betaine is also good to help prevent cancer, it is a methyl compound that works at the cellular level. Choline is interchangeable if you have adequate amounts of the enzymes to convert it. It helps to resist mutations. You can get betaine from stuff like spinach but it is best cooked, or you can get it from eating beets and veggies containing this methyl compound It is a little different than caffeine though.

It almost seems that the things they told us not to drink or eat for years actually help protect us from disease. Even real butter has some cancer protective properties. Depending on the type of cancer, there are some good food chemistries to utilize to reduce your chances of getting it. Taking the wrong medicine for the wrong type of cancer applies to food as medicine too.

a reply to: IgnoranceIsntBlisss

My Oncologist says food is for prevention, medical science is for tackling disease.

Also no anti-oxidants when you have cancer growing in your body. AOs protect cells, all cells and they actually make it harder for your body to fight the cancer.

a reply to: Kali74

"Air" = chemistry
"Earth" = chemistry
"Food" = chemistry
"Biology" = chemistry
"Cancer" = chemistry
"You" = chemistry

"Drugs" = chemicals

"Chemo" = chemical "medicine" (aka drugs) = chemicals

"Medicine" tends to be isolated compounds (chemicals), synthetic compounds (chemicals)... the right ones for a task that is.

"Food" tends to be complex substances that contain any of an endless variety of chemicals, usually involving proteins, carbs, antioxidants, and so on.

As such, "turmeric" = 'food'. The "curcuminoids" within turmeric = 'drugs' (the finest medicines in the known universe per science).

Some, probably most medical tasks (cancer or otherwise) are a multi-tumbler combination lock to be 'picked'. Like with locks, if you lack all the dial positions then brute force breaks the lock open (maybe). With cancer each 'specimen' is a lock with something like 10 tumblers; current cancer industry comes in with one or two 'maybe' tumbler settings and hits them with a hammer (where there are hundreds of "proper" cancer types, and in each specific type possibly well numerous specific combinations of cancer lines (tumors are more like multi cell type organisms as far as anything I've read in PubMed has ever suggested).

"Personalized" "medicine" is the future, but for now the industry isn't that smart, the research science is still lacking in various specifics across the spectrum, few regular folks have any clue about it, and even less could afford it even if the industry has already developed a vast archive of trial completed synthetic 'tumbler' keys to apply to each and every 'lock' from one person to the next (which it hasn't).

By the very nature of the 3 phase trial process, where the trials tend to involve singular chems attempted on folks at something next to random in the grand scheme, where if something doesn't "work" then it isn't approved, well the personalized medicine front is sooo far away with old industry thinking going along this FDA model (that suits the industry model of $10,000 per dose for brute force singular compounds, and people getting sick a couple years after and doing it all over again). The whole approach needs to shift towards combinations of 'chemicals' for given challenges (ANY chemicals whether natural or patented synthetic), where the safety of the combinations is more of the thinking while of course getting results too. As far as I'm concerned, anything less is disingenuous, sociopathic, etc.

Were the # does all the donations go

originally posted by: IgnoranceIsntBlisss
a reply to: Kali74

"Air" = chemistry
"Earth" = chemistry
"Food" = chemistry
"Biology" = chemistry
"Cancer" = chemistry
"You" = chemistry

"Drugs" = chemicals

"Chemo" = chemical "medicine" (aka drugs) = chemicals

I think you'll find it's a little bit more complicated than that.

a reply to: GetHyped

Everything that exists is CHEMISTRY. A lack of CHEMISTRY is known as a "vacuum". It really all is as simple as that.

Paging Phage!!! Am I wrong here?

a reply to: seasonal

Great Information!

Thank you.

a reply to: infolurker
You are welcome


In the story it says it could be a treatment for ALS. I wonder how it could help with that.