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Recent study out of the University of Ottawa opens door for new disease therapies in cancer, ALS, Fragile X Syndrome and others.
Part of what makes cancer cells so devastating is their ability to fight back against treatments -- sometimes they work, sometimes they don't. But what if we could take away cancer cells' defences altogether?
Researchers from the University of Ottawa have taken an important step forward to doing just that. Dr. Kristin Baetz says the results of a three-way research collaboration could open doors to new therapeutics to treat a variety of diseases, including cancer.
Dr. Baetz is an associate professor at uOttawa's Faculty of Medicine and Director of the Ottawa Institute of Systems Biology. Her lab studies stress granules (SGs), which are structures produced by the body's cells to protect against environmental stressors. Unfortunately, SGs also help cancer cells defend themselves against chemotherapeutic treatments,
"The first step in figuring out how to prevent this from happening is to understand how stress granules are formed and disassembled," explains Dr. Baetz, "and we now have key information."
Using yeast cells, her lab has identified a class of enzymes that play an active role in regulating SG formation. Deactivating this class of enzyme has a direct correlation to lowering SG levels.
"We've discovered one way to decrease stress granule formation, plus we have therapeutics -- so we're well positioned to explore how this strategy might work on diseases," Dr. Baetz says.
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required for stress granule formation upon glucose deprivation but not heat stress. Further, the Tip60 complex, the human homolog of the NuA4 complex, is required for stress granule formation in cancer cell lines. Surprisingly, the impact of NuA4 on glucose-deprived stress granule formation is partially mediated through regulation of acetyl-CoA levels, which are elevated in NuA4 mutants. While elevated acetyl-CoA levels suppress the formation of glucose-deprived stress granules, decreased acetyl-CoA levels enhance stress granule formation upon glucose deprivation. Further our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1. Altogether this work establishes both NuA4 and the metabolite acetyl-CoA as critical signaling pathways regulating the formation of glucose-deprived stress granules.
originally posted by: IgnoranceIsntBlisss
a reply to: Kali74
"Air" = chemistry
"Earth" = chemistry
"Food" = chemistry
"Biology" = chemistry
"Cancer" = chemistry
"You" = chemistry
"Drugs" = chemicals
"Chemo" = chemical "medicine" (aka drugs) = chemicals