Radical New Understanding of Genetic Disease

I've always argued that somehow Genetic disease was improbable, because their were too many factors that came in(environment, social and family relations, lifestyles and many more)

In short, the DNA and thus the biology of an organism are constantly adjusting themselves to signals from outside the cells, including energetic information arising from thoughts and beliefs.

Learning GNM 2009

Genetic Disease

We are responsible in general for what goes on around us, and so in the same way we are responsible for what goes on inside of us.

It's the coming realization of the 5th dimension, and i believe it is something to celebrate. We should all get rid of fear completely, and embrace love and unity.

Let the sun shine in

reply to post by GoodFella


We are past the 5th dimension. Citizens should at least be able to understand the 6th dimension.

In my other thread I help others help themselves understand their 'initial research' into the 12th dimension.

There is already another thread that discusses genetic variations and delusions.

The field of Epigenetics IS gaining mainstream recognition, but slowly.

University/College textbooks about this field are starting to be released by mainstream publishers.

This new field is surely going to lend support to and strengthen Toxicology, often the most ignored scientific field today and laughed at by chemical/biotechnological corporations.

[edit on 2-3-2010 by jjjtir]

Originally posted by jjjtir
The field of Epigenetics IS gaining mainstream recognition, but slowly.

University/College textbooks about this field are starting to be released by mainstream publishers.

This new field is surely going to lend support to and strengthen Toxicology, often the most ignored scientific field today and laughed at by chemical/biotechnological corporations.

[edit on 2-3-2010 by jjjtir]

Epigenetics has been "mainstream" for well over a decade. It was "mainstream" once we realized methylation patterns were changeable and heritable. This discovery was made even before the human genome project began.

My medical genetics class in 2000 focused on epigenetics for about 10 hours worth of lecture, which is a pretty good mount of time when you consider the breadth of the class.

Also, I don't know of any "chemical/biotechnological corporations" who laugh at epigenetics. They were the second largest source of epigenetic research funding, right behidn the United States government via the NIH and NSF.

reply to post by VneZonyDostupa


I was referring to Toxicology. Corporations hide the safety of chemical products, and downplay independently-conducted studies that show toxic effects(atrazine herbicide by syngenta is the latest example in the news).

Epigenetic side-effects of drugs and epigenetic carcinogens for example, I don't see them being regularly publicized.

This side of epigenetics doesn't seem that mainstream to me.

But for the rest I pretty much agree with you that it is mainstream.

[edit on 3-3-2010 by jjjtir]

reply to post by jjjtir


There isn't a whole lot of epigenetic change that would truly alter the toxicity of a substance. Unless there is an abnormal activation/deactiviation of a CYP gene (drug metabolism), or one that causes an inborn error of metabolism (unlikely), there shouldn't be anything that would effect drug toxicities.

Cancer rates, however, are *highly* dependent on epigenetic motifs, due to activation/deactivation of oncogenes.

www.guardian.co.uk...

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Further research established that the inherited change had altered the chicks' "gene expression" – the way certain genes are turned "on" or "off", bestowing any given animal with specific traits. The stress had affected the mother hens on a genetic level, and they had passed it on to their offspring.

The Swedish chicken study was one of several recent breakthroughs in the youthful field of epigenetics, which primarily studies the epigenome, the protective package of proteins around which genetic material – strands of DNA – is wrapped. The epigenome plays a crucial role in determining which genes actually express themselves in a creature's traits: in effect, it switches certain genes on or off, or turns them up or down in intensity. It isn't news that the environment can alter the epigenome; what's news is that those changes can be inherited. And this doesn't, of course, apply only to chickens: some of the most striking findings come from research involving humans.

www.youtube.com...&hl=en_US&fs=1&

We've learned that huge proportions of the human genome consist of viruses, or virus-like materials, raising the notion that they got there through infection – meaning that natural selection acts not just on random mutations, but on new stuff that's introduced from elsewhere. Relatedly, there is growing evidence, at the level of microbes, of genes being transferred not just vertically, from ancestors to parents to offspring, but also horizontally, between organisms.

www.youtube.com...&hl=en_US&fs=1&

www.time.com...

For instance, fruit flies exposed to a drug called geldanamycin show unusual outgrowths on their eyes that can last through at least 13 generations of offspring even though no change in DNA has occurred (and generations 2 through 13 were not directly exposed to the drug). Similarly, according to a paper published last year in the Quarterly Review of Biology by Eva Jablonka (an epigenetic pioneer) and Gal Raz of Tel Aviv University, roundworms fed with a kind of bacteria can feature a small, dumpy appearance and a switched-off green fluorescent protein; the changes last at least 40 generations. (Jablonka and Raz's paper catalogs some 100 forms of epigenetic inheritance.)


Darwin, who was 84 years younger than Lamarck, was the better scientist, and he won the day. Lamarckian evolution came to be seen as a scientific blunder. Yet epigenetics is now forcing scientists to re-evaluate Lamarck's ideas.


The coherence between the ALSPAC and Overkalix results in terms of the exposure-sensitive periods and sex specificity supports the hypothesis that there is a general mechanism for transmitting information about the ancestral environment down the male line," Pembrey, Bygren, Golding and their colleagues concluded in the European Journal of Human Genetics paper. In other words, you can change your epigenetics even when you make a dumb decision at 10 years old. If you start smoking then, you may have made not only a medical mistake but a catastrophic genetic mistake.


There are at least 210 cell types in the human body — and possibly far more, according to Ecker, the Salk biologist, who worked on the epigenome maps. Each of the 210 cell types is likely to have a different epigenome.


www.youtube.com...&hl=en_US&fs=1&

www.newscientist.com..."

Now, with advantageous genetic innovations able to flow horizontally across the entire system the code readily discovered the overall optimal structure and came to be universal among all organisms. "In some sense," says Woese, "the genetic code is a fossil or perhaps an echo of the origin of life, just as the cosmic microwave background is a sort of echo of the big bang. And its form points to a process very different from today's Darwinian evolution." For the researchers the conclusion is inescapable: the genetic code must have arisen in an earlier evolutionary phase dominated by horizontal gene transfer.

www.youtube.com...&hl=en_US&fs=1&"

As more genomes are sequenced, ever more incongruous sequences of DNA are turning up. Comparisons of the genomes of various species including a frog, lizard, mouse and bushbaby, for example, indicate that one particular chunk of DNA found in each must have been acquired independently by horizontal gene transfer (Proceedings of the National Academy of Sciences, vol 105, p 17023). "The importance of this for evolution has yet to be seriously considered."