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A response has come from China to the respiratory disease caused by the new coronavirus (SARS-CoV-2) that emerged in December 2019 in this country. Indeed, following the very recent publication of results showing the in vitro activity of chloroquine against SARS-CoV-2, data have been reported on the efficacy of this drug in patients with SARS-CoV-2-related pneumonia (named COVID-19) at different levels of severity.
Thus, following the in vitro results, 20 clinical studies were launched in several Chinese hospitals. The first results obtained from more than 100 patients showed the superiority of chloroquine compared with treatment of the control group in terms of reduction of exacerbation of pneumonia, duration of symptoms and delay of viral clearance, all in the absence of severe side effects
Regarding viruses, for reasons probably partly identical involving alkalinisation by chloroquine of the phagolysosome, several studies have shown the effectiveness of this molecule, including against coronaviruses among which is the severe acute respiratory syndrome (SARS)-associated coronavirus. We previously emphasised interest in chloroquine for the treatment of viral infections in this journal, predicting its use in viral infections lacking drugs.
The central clinical TF will recommend antiretroviral agents Kaletra, antimalarial agents Chloroquine, and Hydroxychloroquine as the primary antiviral drugs for COVID-19.
Chloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting (COPCOV)
The study is a double-blind, randomised, placebo-controlled trial that will be conducted in health care settings. After obtaining fully informed consent, the investigator will recruit healthcare workers, or other individuals at significant risk who can be followed reliably for 5 months. 10,000 participants will be recruited and the investigator predict an average of 200 participants per site in 50 sites.
Side effects include neuromuscular, hearing, gastrointestinal, brain, skin, eye, cardiovascular (rare), and blood reactions.[13]
Seizures[13]
Deafness or tinnitus.[13]
Nausea, vomiting, diarrhea, abdominal cramps, and anorexia.[13]
Mild and transient headache.[13]
Skin itchiness, skin color changes, hair loss, and skin rashes.[13]
Chloroquine-induced itching is very common among black Africans (70%), but much less common in other races. It increases with age, and is so severe as to stop compliance with drug therapy. It is increased during malaria fever; its severity is correlated to the malaria parasite load in blood. Some evidence indicates it has a genetic basis and is related to chloroquine action with opiate receptors centrally or peripherally.[14]
Unpleasant metallic taste
This could be avoided by "taste-masked and controlled release" formulations such as multiple emulsions.[15]
Chloroquine retinopathy
May be irreversible.[13] This occurs with long-term use over many years or with high doses. Patients on long-term chloroquine therapy should be screened at baseline and then annually after five years of use.[16] Patients should be screened for vision changes such as blurring of vision, difficulty focusing, or seeing half an object.[13]
Hypotension and electrocardiographic changes[13][17]
This manifests itself as either conduction disturbances (bundle-branch block, atrioventricular block) or cardiomyopathy – often with hypertrophy, restrictive physiology, and congestive heart failure. The changes may be irreversible. Only two cases have been reported requiring heart transplantation, suggesting this particular risk is very low. Electron microscopy of cardiac biopsies show pathognomonic cytoplasmic inclusion bodies.
originally posted by: mobiusmale
a reply to: muzzleflash
Yeah, I'm on a real honey kick myself right now...I'm with you on that.
Your list of side effects looks like the end of every drug commercial on TV...they list every possible negative outcome, no matter how remote a possibility, as a way to try to avoid legal liability when people use the product.
originally posted by: Bicent
Good news. I hope this is true. I want my normal back. 🤞
originally posted by: muzzleflash
originally posted by: Bicent
Good news. I hope this is true. I want my normal back. 🤞
That makes no sense. We had 1000 items at the store that kill Corona and you refused to believe decades of research?
Then you clapped when they touted out some pharma Corp poison?
This whole thing is so fake lol.