Interesting study on Chinese childrens exposure to Flouride and effects on intelligence....

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posted on Feb, 17 2014 @ 10:54 AM
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Very interesting read this....

I for one have been talking of the dangers of water fluoridisation for years... seems the main stream may just be catching up.....

www.liveleak.com...

Please read and digest...

PA




posted on Feb, 17 2014 @ 11:52 AM
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reply to post by PerfectAnomoly
 


Your reference is from 2010, and part of a large body of evidence linking fluoride to various diseases. One of the main reasons this link is not recognized is because it leads inevitably to the spectre of prion, prion-related and protein misfolding diseases (proteinopathies). Check out this thread for more info on the cover-up: More Disinformation from "Reliable" Mainstream Sources about Prion Disease?. Here are a few quick picks of the science linking fluoride to protein folding disorders.


Role of Unfolded Protein Response in Affecting Osteoblast Differentiation Induced by Fluoride

The objective of this study was to determine the expression of classic bone markers and unfolded protein response (UPR) signaling factors through MC3T3-E1 cells exposed to varying concentrations of fluoride. Excessive fluoride exposure caused the skeletal disease. During this process, osteoblasts played a critical role in the advanced skeletal fluorosis. Recent literature showed that endoplasmic reticulum (ER) stress and UPR were involved in numerous aspects of bone biology. Our results indicated that co-exposure of low-dose fluoride and mineral induction medium stimulated the expression of alkaline phosphatase, runt-related transcription factor 2 (Runx2), and osterix in MC3T3-E1 cells. Accordingly, the expression of double-stranded RNA-activated protein kinase (PKR)-like ER kinase, activating transcription factor 6, and X-box binding protein 1 also increased under the same fluoride exposure condition. The upregulation of three UPR factors was similar with osteogenic differentiation markers and transcription factors, which implied the relation between osteoblast differentiation and UPR pathways. Moreover, the role of UPR affecting osteoblast differentiation was investigated by decreasing the expression of binding immunoglobulin protein (BiP) mRNA through small interfering RNA (siRNA) technique. BiP knockdown led to suppress activation of UPR pathways. The deletion of BiP expression hardly stimulated the osteogenic cells differentiation but inhibited cell function under fluoride and mineralization induction exposure. In conclusion, fluoride had dual effect on osteogenic action. The UPR possibly involved in the mechanism of osteoblasts differentiation induced by fluoride.


Fluoride Induces Endoplasmic Reticulum Stress and Inhibits Protein Synthesis and Secretion

….higher levels of F− exposure can result in dental fluorosis, which is manifested as mottled, discolored, porous enamel that is susceptible to decay (DenBesten 1999). High F− doses can cause skeletal fluorosis that may result in bone fracture (Boivin et al. 1989). High F− doses may also cause renal toxicity (Zager and Iwata 1997), epithelial lung cell toxicity (Thrane et al. 2001), and reproductive defects (Ghosh et al. 2002).


Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus.



posted on Feb, 17 2014 @ 06:24 PM
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I view the widespread use of fluoridation as a convenient method of getting rid of an industrial waste (from aluminium production)whilst managing to dumb down the populace for easier control/ exploitation................





 
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