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Logical injury assessment
With the aim of improving the survival rate of injured soldiers, US Scientists have designed a biocomputing system that is capable of diagnosing multiple injuries from a sample of urine or blood.
Explosions on battlefields can result in patients with multiple injuries that need quick diagnosis. Currently, this is done by physical examination and a comprehensive series of laboratory tests in hospital. When an organ is injured, the body releases chemicals that can be used as biomarkers to indicate particular internal injuries. Multiple injuries release a wide range of biomarkers and now a team led by Evgeny Katz from Clarkson University, and Joseph Wang at the University of California San Diego, have developed a diagnostic tool that can be used in the field and is able to differentiate between many chemical inputs to provide a diagnosis.
The system comprises six logic gates made from enzymes that are sensitive to twelve biomarker inputs associated with six different pathological conditions, including soft tissue injury, abdominal trauma and brain injury. The enzyme gates each produce a logic output (1 or 0), which together form a 6-bit 'injury code', that allows full diagnosis of the patient's condition.
Multiplexing of injury codes for the parallel operation of enzyme logic gates
The development of a highly parallel enzyme logic sensing concept employing a novel encoding scheme for the determination of multiple pathophysiological conditions is reported. The new concept multiplexes a contingent of enzyme-based logic gates to yield a distinct injury code corresponding to a unique pathophysiological state as prescribed by a truth table.