Humans from livestock...makes you wonder.
"This very important paper suggests that livestock oocytes are extremely unlikely to be suitable as recipients for use in human nuclear transfer"
www.reuters.com...
Animal-human clones don't work, U.S. company finds
Mon Feb 2, 2009 2:47pm EST
By Maggie Fox, Health and Science Editor
WASHINGTON (Reuters) - Researchers who tried to use mouse, cow and rabbit eggs to make human clones said on Monday the effort failed to produce
workable embryos but added that they showed human cloning should work in principle.
Mixing human and animal cells does not appear to program the egg properly, said Dr. Robert Lanza of Massachusetts-based Advanced Cell Technology.
But using human cells did reprogram the egg cell or oocyte and activate the genes needed to make a viable embryo, Lanza and colleagues reported in the
journal Cloning and Stem Cells.
Several teams have tried to make animal-human hybrids as a source of embryonic stem cells, the master cells of the body. Because human eggs are scarce
-- it requires a surgical procedure to get them from a woman -- some scientists came up with the idea of using animal egg cells.
The cloning technique is called somatic cell nuclear transfer. The nucleus is removed from an egg cell and replaced with the nucleus from another type
of cell from the donor animal or person who is to be cloned.
Done right, the process starts the egg growing and dividing as if it had been fertilized by a sperm, but the resulting embryo carries mostly the DNA
of the donor.
"The idea was to simply to plunk a patient's DNA into an empty cow or rabbit egg -- and presto -- you reprogram the DNA back into a stem cell,"
Lanza said in a telephone interview.
But teams that have tried to do this have always ended up with what looks like a cell dividing over and over to become an embryo, but which eventually
fizzles out.
"For the last decade, we've carried out literally hundreds of experiments trying to create patient-specific stem cells using animal eggs," Lanza
said.
BEAUTIFUL HYBRIDS
"We got beautiful little hybrid embryos, but it didn't work no matter how hard we tried."
A mouse-human hybrid petered out after just one division. The cow and rabbit human hybrids went further, but stopped at the point when maternal DNA is
supposed to kick in and turn the ball of cells into a proper embryo, Lanza said.
Lanza's team used a new method called global gene expression analysis to see which genes were turned on and off as the eggs grew.
"We never had the tools before to actually look inside the cell and see what's going on," Lanza said. It appears that using the egg of another
species turns off the genes needed to make an embryo instead of turning them on, he said.
But the human-human clone did turn on the right genes, although it, too stopped dividing before it could produce stem cells, Lanza said.
"We see exactly the same genes turned on in a normal embryo are actually turned on in a human clone," he said.
Ian Wilmut of the University of Edinburgh, one of the scientists who cloned the first mammal, Dolly the sheep, and editor of the journal, called the
results disappointing.
"This very important paper suggests that livestock oocytes are extremely unlikely to be suitable as recipients for use in human nuclear transfer,"
Wilmut said in a statement.
But Lanza said it might be possible to use other methods to create "banks" of stem cells that match the several hundred tissue types found among
humans.
This could include cloning humans, using a single cell from growing embryos used for fertility treatment, or a new method called induced pluripotent
stem cells, made by taking a sample of skin and reprogramming the cells to act like embryonic stem cells, Lanza said.
|
I'm pretty sure they already have cloned humans before. I had a person who looked exactly like me pop up in various situations over the years with
different people who know me, and they absolutely didn't believe that I wasn't anywhere near them on that occasion. This person, when I went to
rehab because of a pot conviction, had been going around to N.A. meetings posing as a heroine addict, and people who came to do meetings at the rehab
center kept recognizing me, and this one dude like really got in my face (you know how some of those people can be...) and was like "WHY ARE YOU IN
DENIAL!?!? IT WAS YOU, MAN!!! IT WAS YOU!!!"
A few of my friends, like 4 years after that, swore I was stalking them at their college classes, wearing disguises and sitting in the back of their
classrooms.
And people who I've never met before always come up to me and go "Hey man! Remember me? From yada yada? Oh man, no wonder you don't remember. You
were so messed up, man!"
Even though I know for certain that I( couln't have forgotten all of these people's faces at parties and such. I don't go out that much.
So... cloning has most likely already happened... and we don't really know how advanced our science is, because of veils upon veils of
compartmentalized secrecy.
Thank YOU, National Security Act of 1947 and Project Paperclip!!!
[edit on 3-2-2009 by dunwichwitch]
|
There is a terminology problem in this article.
The experimentals they are describing are not hybrids. They are CYBRIDS.
If they did develop, they would be humans pure and simple. Humans with a different mtDNA signature, but humans all the same. Fully human nuclear DNA
with a cellular power pack that was not human.
A hybrid would be a combine the nuclear DNA of two animals that do not share the same lineage. Using the mtDNA (ovum) of the primary animal. A human
and a sheep for example. Which exists BTW. Yes, that is correct there is an actual sheeple.
www.msnbc.msn.com...
|
reply to post by dunwichwitch
Hmmmmmm.
Maybe there is human cloning; either that or you have multiple personalities and you don't remember the "other half"
hahaha.
I've been told similar things before, maybe we all have an evil twin out there.
|
|
reply to post by dunwichwitch
I don't want to jack the thread here but I've had more than a few people tell me they knew someone that looked exactly like me. I always kinda
think 'poor bastard'. I've never seen anyone I thought looked like me.
Human animal hybrids (can't get GW out of my head now), I think we have enough problems. I hope it doesn't work for the animals sake if nothing
else.
|
Again - what the article is refering to is NOT a hybrid.
A hybrid is when you combine the nuclear of two different things. A tomato with a fish gene. A pig that has DNA to grow a human liver. A
recombinant between species that cannot recombine in the natural world.
A cybrid is when you take the nuclear DNA out of an ovum and then put a complete nuclear DNA from something else into that ovum and let it develop -
if it can.
A clone comes close to being a cybrid - however a true clone would need to have the same ovum type as the original person. An often overlooked
matter. All the same they aren't really cybrids because the ovum being used is human.
An ovum of another species in which the nuclear DNA has been removed, and then DNA not from that species is inserted into it instead. What you would
have is NOT a hybrid. If this was a human in a rabbit ovum, you'd have a human. If this was a human reproduced from a chimpanzee ovum, it would
still be a human.
This is REALLY important for you all to start understanding. It has political ramifications. Cybrids will be happening at some point. If people do
not understand that a cybrid is just a human, what will happen is that societies with tendencies to caste structures will create a new class of
"non-human" humans to encompass these people.
Understanding this BEFORE it starts working, will save the human race from another several hundred years of brutal stupidity towards another group.
I'm not educating you because it is just fun to explain the difference between yDNA, mtDNA and nDNA to people.
[edit on 2009/8/18 by Aeons]
|
Aeons nailed it. Awesome explanation.
I was going to repaste this part:
"WASHINGTON (Reuters) - Researchers who tried to use mouse, cow and rabbit eggs to make human clones said on Monday the effort failed to produce
workable embryos but added that they showed human cloning should work in principle. "
They were using the eggs of other species to try and clone humans, instead of using human eggs because that would be human cloning and the jury is
still out on whether we should do that.
Umm... here's a good comparison. Remember all the tests they're doing with the Tasmanian Tiger/Thylacine? (/mqv578) To summarize-
they're using the eggs of mice and inserting the genes of thylacines in order to try and recreate some genetic material.
So technically the embryos are hybrid (part mouse part human) but not really hybrids. They just want to see which genes become activated.
|
