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A strong earthquake measuring 7.7 rocked arid northern Chile sparking panic and triggering a tsunami warning for the region, officials said.
"It is a major quake," said the director of Chile's National Emergency Office, Carmen Fernandez.
Authorities say two people have been killed an at least 20 injured.
Tocopilla Mayor Luis Moncayo said that at least 4,000 people in the port city had been left homeless by Wednesday's quake and some 1,200 buildings demolished.
About 500 emergency housing units have been sent to the city of 27,000 people.
There have been so many aftershocks that start with a big noise, a humming noise, and then the ground starts moving and people start to run away."
In Maria Elena on Wednesday, a small town south-east of Tocopilla, 20 people were hurt and 70% of the town's houses were destroyed.
In Antofagasta, the airport was damaged, Chilean radio reported, while some 45 people were injured.
Chile's largest copper mines are in the quake zone, and production was temporarily halted on Wednesday. The nation is the world's largest copper producer.