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Aging Cause Found in Mice, Could Help Humans
The buildup of mutated DNA triggers aging in mice, according to a new study that could help advance research into human aging.
As a lifetime of small mutations in the genetic code build up, cells begin to die. These deaths lead to such things as graying hair and weight changes, hearing and vision impairment, loss of muscle and weakened bones.
"We think that the key to what is happening in aging is that as (genetic) mutations or DNA damage accumulates, critical cells die," said Tomas Prolla of the University of Wisconsin-Madison. "These experiments favor a major role for programmed cell death in aging."
This study, expected help scientists understand how humans grow old and die, is detailed in the July 15 issue of the journal Science.