I have been following the different types of vaccines being developed to treat COVID. The articles support that a large number of the vaccines are
using nanotechnology. I am paying close attention to the mRNA vaccines that use nanotechnology - the mRNA vaccines seems to be where the industry is
headed. The mRNA vaccines are new technology and represent a significant portion of the vaccines being tested.
“Nanoparticles and viruses operate at the same size scale; therefore, nanoparticles have an ability to enter cells to enable expression of antigens
from delivered nucleic acids (mRNA and DNA vaccines) and/or directly target immune cells for delivery of antigens (subunit vaccines). Many vaccine
technologies employ these direct benefits by encapsulating genomic material or protein/peptide antigens in nanoparticles such as lipid nanoparticles
(LNPs) or other viruses such as Ads. BioNTech/Pfizer and Moderna encapsulate their mRNA vaccines within LNPs while the University of
Oxford/Astrazeneca (from here on out referred to as Oxford/Astrazeneca) and CanSino incorporate antigen-encoding sequences within the DNA carried by
Ads.(17,19,22,23) Novavax decorates recombinant S proteins of SARS-CoV-2 onto their proprietary virus like particle (VLP) nanoparticles.(49) The
nanoparticles are described in further detail in the discussion below.”
This article discusses the pros of mRNA vaccines. The article emphasizes that mRNA vaccines are straightforward to produce (in layman’s terms...$$$
for the vaccine manufacturer). horizon-magazine.eu...
This article explains how mRNA vaccines are rapidly mass produced “The mRNA approach is “the one with the most unknown unknowns,” said Richard
Braatz, a chemical engineering professor at the Massachusetts Institute of Technology. That said, manufacturing mRNA vaccines could be easier in some
ways than shots based on older technologies, because mRNA vaccines don’t require as lengthy a purification process, Braatz said.”
One test subjects experience with an mRNA vaccine.
This article provides a more in-depth look at potential complications “ Several different mRNA vaccines have now been tested from phase I to IIb
clinical studies and have been shown to be safe and reasonably well tolerated (TABLES 2,,3).3). However, recent human trials have demonstrated
moderate and in rare cases severe injection site or systemic reactions for different mRNA platforms22,91. Potential safety concerns that are likely to
be evaluated in future preclinical and clinical studies include local and systemic inflammation, the biodistribution and persistence of expressed
immunogen, stimulation of auto-reactive antibodies and potential toxic effects of any non-native nucleotides and delivery system components. A
possible concern could be that some mRNA-based vaccine platforms induce potent type I interferon responses, which have been associated not only with
inflammation but also potentially with autoimmunity. Thus, identification of individuals at an increased risk of autoimmune reactions before mRNA
vaccination may allow reasonable precautions to be taken. Another potential safety issue could derive from the presence of extracellular RNA during
mRNA vaccination. Extracellular naked RNA has been shown to increase the permeability of tightly packed endothelial cells and may thus contribute to
edema. Another study showed that extracellular RNA promoted blood coagulation and pathological thrombus formation. Safety will therefore need
continued evaluation as different mRNA modalities and delivery systems are utilized for the first time in humans and are tested in larger patient
The headlines this morning are all consistently touting this new mRNA vaccine - Pfizer, BioNTech say Covid vaccine is more than 90%
effective—‘great day for science and humanity’
I’m sure that big pharma always puts our well-being first and foremost...no reason for concern...move along.
edit on 9-11-2020 by Buvvy
because: Adding info