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Metformin is an Endocrine Disruptor and Threat to Humankind

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posted on Jul, 27 2017 @ 10:21 AM
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a reply to: TiredofControlFreaks

Insulin pills will hit the market soon so forget injectable and inhalable insulin. Inhalable insulin carries the risk of lung cancer while injectable insulin can be inconvenient for people esp children. I read that phase 3 clinical trials for oral insulin pills will begin in the near future following the successful implementation of the Phase IIb trial. Here is the press release:

Oramed Announces End-of-Phase 2 Meeting with FDA to Initiate Phase 3 Program

JERUSALEM, July 11, 2017 /PRNewswire/ — Oramed Pharmaceuticals Inc. (NASDAQ: ORMP) (www.oramed.com), a clinical-stage pharmaceutical company focused on the development of oral drug delivery systems, announced today that the U.S. Food and Drug Administration (FDA) has agreed to schedule an End-of-Phase II meeting with Oramed for its successfully completed Phase IIb trial of its oral insulin capsule ORMD-0801 in the treatment of type 2 diabetes. The Phase IIb trial met primary and secondary endpoints by indicating a statistically significant lowering of glucose relative to placebo.


Source: www.oramed.com...



edit on Julam17 11 20 by Rextiberius because: error correction




posted on Jul, 27 2017 @ 10:49 AM
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a reply to: Cropper

No, it is not caused by sugar despite the common, popular misconception. The body actually needs, craves for sugar and the brain will go into coma within hours if deprived of glucose.

The actual cause appears to be unsaturated oil that prevents glucose oxidation. This has been scientifically known for quite some time now. The metabolic dysfunction goes under the (inappropriate) name of The Randle Cycle. Only recently has this been brought to wider public knowledge, thanks to the untiring work of Ray Peat, Phd. Here are some articles where Peat articulates the actual causative factors:

www.functionalps.com...
raypeat.com...
raypeat.com...
raypeat.com...
raypeat.com...



posted on Jul, 27 2017 @ 10:53 AM
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a reply to: Rextiberius

Has a delayed on-set of action which = it will not control post-prandial glucose spikes after a meal which = it will be inferior in comparison to a CGM and Inhaled insulin with time in range. The inhaled insulin flatlines glucose spikes almost immediately after taking it. Time in range is everything and the dumbass Endos have only just now started to realize this hence, what the 2017ADA was focused on.

This is just another garbage pill. Endogenous insulin is secreted in a specific manner and physiologically this pill does not mimic that.

edit on 27-7-2017 by M4ngo because: (no reason given)

edit on 27-7-2017 by M4ngo because: Misspelled word



posted on Jul, 27 2017 @ 11:17 AM
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a reply to: auroraaus

Doing exercise, etc only tackle the symptoms of high glucose and do not address the root cause. The root cause being unsaturated oils. If you could keep the intake of unsaturated oils as close as possible to zero then you'll be able to defeat this awful disease. Never cook food with/in oil - the preferred method is steaming. A little coconut oil or butter/ghee can be added after the food is cooked. It is best to keep cooking oils out altogether during the therapy period. It takes up to 4 yrs for the stored unsaturated oils in the body to exit the system!!

Saturated oils like butter/ghee/coconut oil in small amounts are fine. The regimen can be tough as it means not eating out - practically all eateries use unsaturated oils, the worst being corn, soy, canola. Within months, you'll see the body fat going down. I reckon this is due to the loss of Subcutaneous Fat, the topmost layer. In time, you'll also lose the Visceral Fat (the one hanging around the internal organs). VF is the one that causes insulin resistance that typifies T2DM. You read up the literature on this subject:

Google "Randle Cycle - Ray Peat"

Another (drastic) way is to do intermittent fasting - you can Google that up too. This was done in some clinical setting at Newcastle University, England and those who took part in the experiment succeeded in reversing their diabetic status. Apparently, fasting helps to reset the malfunctioning metabolism.

You can read a bit here:

www.ncl.ac.uk...
www.ncl.ac.uk...



posted on Jul, 27 2017 @ 11:36 AM
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a reply to: dianajune

Sorry to hear about your health woes. Try this: cut out all sources of unsaturated oil and never use them to cook your foods. This means not eating out, to avoid the unsaturated oils used in eateries... Small amounts of saturated oils like butter and coconut oils are fine. Take a Vit E cap of 300 - 400 IU daily (helps to repair the system damaged by unsaturated oils). Do not eat nuts as these often contain very high unsaturates; no fried foods of any kind and no fish oils too. Do this for a few months and see whether your diabetic condition will improve or not. Read up articles on the subject of "The Randle Cycle" to get a better understanding of the inhibition of glucose oxidation by unsaturated oils. Check your thyroid health status as well for it can be greatly compromised by chronic ingestion of unsaturated oils.



posted on Jul, 27 2017 @ 12:31 PM
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a reply to: antibyte

Yes, I've heard of Berberine but have not tried it yet. I am encouraged by this article by Dr Frank Shallenberger:


Can this herb completely replace drugs for Type-2 Diabetics?
www.faim.org...



posted on Jul, 27 2017 @ 01:32 PM
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a reply to: Logarock
Stick with that Keto "diet" for your T2 issues. It's the way to go. I put diet in parentheses as it shouldn't be a diet in the conventional sense (short term fix) but a complete lifestyle change. Commit to it...stick with it...for good. Yes, it sucks that you'll miss out on some tasty foods/treats. But, in my opinion, that's a fair trade off if you eliminate the blindness and amputations that come with T2.



posted on Jul, 27 2017 @ 01:38 PM
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originally posted by: M4ngo
Let me explain again: It is a fact that Metformin induces beta-amyloid aggregates.



So remember: Endocrinologists themselves published this in their International Journal:While metformin by itself increases the formation of Β-amyloid


Once again: yes, but only with cell cultures in a petri dish, not with humans.

The study also found that Metformin may have crossed into the brain of mice, but (like I said already) what happens with mice most of the time does not translate to humans.

If you look at the molecular structure of Metformin you'll see it cannot permeate the BB barrier (blood/brain). But clinical trials with humans are needed to study this more thoroughly, perhaps to see if there is some sort of active transport that could cross the BB barrier or if this is only happening with mice. We actually need more studies with mice to replicate these findings.

So, like I have already said: this study is not proof of Metformin causing Alzheimer's.



Now, your second article: Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

Yes, the scientists stated that their observations showed a possible link between Metformin and increased risk of cognitive impairment. However, it is not conclusive as they also said (from your article):


This association was weakened after adjusting for serum vitamin B12 levels; thus any effect metformin has on cognitive performance may be at least partially mediated by altering serum vitamin B12 levels.


They don't know whether it's the Metformin or the untreated vitamin B12 deficiency caused by the drug (to a small percentage of patients). They also said:


There was insufficient information regarding the duration of metformin use, the severity ofdiabetes(e.g.,HbA1c levels), duration of diabetes, or use of other antidiabetic drugs to enable us to investigate these effects in our study, particularly because these findings were based on a small sample.


They couldn't come to a conclusion because the study had too many limitations, lack of essential knowledge that may well give completely different results if those variables had been adjusted. But there is more, based on the study small number of patients:


We recommend a larger study to examine the effect of dose and duration of metformin use, and the effects of other antidiabetic agents using a battery of cognitive assessments and following participants over a number of years.


The authors themselves recognized how incomplete and inaccurate their study was. So no, this article is not proof of Metformin causing cognitive impairment or decline.



I will now add my own articles, with big letter so everybody can see it, because I worry that some will stop treating their diabetes after reading this thread and I have seen how the condition can damage people's lives (I have met patients who did not believe untreated diabetes was dangerous and they ended up blind or with amputated limbs, kidney failure etc etc).

Short term administration of Metformin has anti-cancer properties with breast cancer patients.

Compared with other antidiabetic treatments combined, use of Metformin was associated with a lower risk of colorectal cancer.

Preclinical evidence suggests that Metformin appears to inhibit the proliferation and growth of certain types of cancer.

There are hundreds of studies like these three.

People please consult your doctor or different doctors, do not listen to unqualified online people you don't know. Do not put your life or your dearest ones at risk.



posted on Jul, 27 2017 @ 03:34 PM
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a reply to: Rextiberius

And to all:

Do NOT, under any circumstances take medical advice from strangers on the internet or from research papers.

Ray Peat has a theory, mind you, its just a theory that saturated fats is the cause of type 2 diabetes. In actuality, there is not one scintella of proof of this theory in the research papers.

What was done is that a diabetic with metabolic syndrome was put on an extreme diet until the fat hanging off of his vital organs was all gone. His health improved and his need for medication went away.

Again, I will remind everyone that diabetes is a progressive diseases. Lifestyle changes can and probably will have the exact same result. But as the disease proceeds, it is likely that the need for medication will come back with a bang.

Diabetics who lose even as little as 10 % of their body wieght experience improvement, at least in the ease of controllling their blood sugar. Some are even successful in being able to control their blood sugar without medication.


Of all the people who lose wieght (by whatever means), something like 84 % of them have re-gained all the wieght within 2 years (and usually a little more).

The man who diabetes was "cured" admits that the diet was very very difficult and he could not have done it without the support of his wife and I guarantee that he had tons of medical support and ongoing monitoring.

This has not, by a very long shot, proved the "cure" for diabetes. It proves that there are 3 "legs" in the management of diabetes. They are medication, diet and exercise. The man leaned heavily on diet and exercise. Lets all wait and see where he is in 2 years.

I will believe that the man's diabetes was "cured" when I see Ray Peat on the podium in Geneva accepting his Nobel prize.



posted on Jul, 27 2017 @ 03:39 PM
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a reply to: M4ngo

M4ngo

Thank you for information on inhalable insulin.

However, you still have not addressed the issue of cost (never mind side affects). for most people, $359.00 that is not covered by insurance, on even a monthly basis (don't know how many cartridges you get for the money) or a weekly basis is simply too much money.

People cannot pay it!



posted on Jul, 27 2017 @ 05:33 PM
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I think the poster who called this "doom porn" may be right. I know that Metformin is currently in clinical trials for off-label use because it has shown serious anti-aging and life extension benefits. In fact, there's a good possibility that it will cause the average person to live to 100 and beyond. And it's cheap enough to be affordable for everyone.

www.lifeextension.com...




edit on 27-7-2017 by sylvie because: (no reason given)



posted on Jul, 27 2017 @ 08:05 PM
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originally posted by: TiredofControlFreaks
a reply to: dianajune

If you can afford it - there is a new drug called jardiance. Jardiance has the effect of weight loss and replaces insulin but it is a new drug so its expensive


Good luck with your pharmacist. please let me know how it has worked out.

You may also want to check out the local y to see if you can use their bike. Cycling is weightless and you may be able to manage it. Also the local community centre may offer some program for water aerobics.

You need exercise to stay off insulin


I'm trying chair exercises and am hoping that's a start to doing more exercise over time. I can do some walking but it's very limited. For example, if I take the bus to Walmart and don't have my power wheelchair with me (like when I need to get alot and bring my folding basket, which I can't use with the wheelchair), I can just about get from the entrance of Walmart to where they keep electric shopping carts.

When I was first diagnosed about 10 years ago (pre-diabetic at first) the endo doc I was seeing at the time referred me to a nutritionist, who gave me a video tape done by Leslie Sanson titled something like "walk down your blood sugar." Not sure about exact title, but I loved that video and used it frequently. That is when I was still able to walk alot more than now.

Fast-forward 10 years or so. I've struggled with huge hernias since then, one of which came close to killing me, the second, not as bad but still serious. Both of them were operated on but the repairs didnt' last. I'm on my third hernia but have no health insurance except for Medicare Part A.

My gp just gave me a very strict diet to stick to, and I am struggling to behave in that regard. I am trying to reverse the bad habits I developed over the years. I hope she will understand this will take time.

Having little insurance isn't making this struggle any easier. I spoke with the pharmacy today about Lantus and was told the price w/o insurance is $28 a dose. This was at Walmart!

I will stick with Glipizide and Metformin for now, the first of which I just started the other day. The Glipizide may now be kicking in because this afternoon my blood sugar went down to 97! I just about fell over when I saw that reading. Bad news is, not long after that I got a call from my gp's office and was told my A1c is now 8.4. The last time I had it checked it was 7.5.

One reason it could be high - other than my weight and poor attempts to diet - is that I had a blister on my leg that I was stupid enough to poke at. It drained for a long time after this happened and is finally getting better. This was about a month or so back. How much of an impact that had on my blood sugar I don't know.

I long for the day when I'll wake up with a blood sugar of 100.

It seems as though Metformin is not working as well as it used to. But isn't there an extended-release version?

Not only am I making dietary changes, I am trying to eat supper earlier than usual. I hope that will help too.

If only I could get Medicare Part B (and D) but can't unless the late signup fee is waived (long story, see my post about that on a different part of ATS). It's getting to the point where I want to post pictures of my huge hernia (clothed, of course!) on Twitter just to get tptb to help, inc. our Potus, Medicare.gov, etc. Going w/o insurance I need to get better is life-threatening imo. I have to do something to shock our gov't into action. How does that old saying go - a picture is worth a thousand words? I can imagine the abuse I will take from trolls if I post those pictures but someone has to understand there are many people out there with a variety of serious health problems who need help and cant' find any.

Sometimes this struggle makes me want to stay in bed. It gets very difficult oftentimes.

edit on 27-7-2017 by dianajune because: typo



posted on Jul, 27 2017 @ 08:18 PM
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originally posted by: Rextiberius
a reply to: dianajune

Sorry to hear about your health woes. Try this: cut out all sources of unsaturated oil and never use them to cook your foods. This means not eating out, to avoid the unsaturated oils used in eateries... Small amounts of saturated oils like butter and coconut oils are fine. Take a Vit E cap of 300 - 400 IU daily (helps to repair the system damaged by unsaturated oils). Do not eat nuts as these often contain very high unsaturates; no fried foods of any kind and no fish oils too. Do this for a few months and see whether your diabetic condition will improve or not. Read up articles on the subject of "The Randle Cycle" to get a better understanding of the inhibition of glucose oxidation by unsaturated oils. Check your thyroid health status as well for it can be greatly compromised by chronic ingestion of unsaturated oils.


I thought that nuts were ok for diabetics as long as they were consumed in moderation? Cutting back on oil is going to be hard because I'm giving up so many other things.


I'll look for the Vit E caps next time I go t the store. Cinnamon caps seem to help some.

At least my thyroid and cholesterol tests were ok when I had bloodwork the other day. Just my blood sugar is going up again.



posted on Jul, 27 2017 @ 09:27 PM
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a reply to: dianajune

I luv nuts too but have stopped eating them. Tough! Yes, it is just as tough to keep unsaturated oils out but I've managed to keep them to a bare minimum for the past 9 mths. I did that to see if it could help - I don't respond well to pharma drugs at all. Am amazed at how this has helped to shrink the waistline and other areas, plus this sense of well being but the glucose work will take much longer from what I gather. Dietary change like this is not a quick fix but a long term investment. I guess the saying one hears in the gym 'no pain, no gain', or, in biz circles, 'no venture, no gain' applies.

If you've have diabetic complications like neuropathy, serrapeptase can help to ease, or even heal, the pain and numbness. Serrapeptase is an inexpensive way to get rid of pain, inflammation, etc.

You can get a lot of tips, support from the Ray Peat Forum community. See the link below:

raypeat.com...
www.functionalps.com...
www.functionalps.com...
raypeatforum.com...
raypeatforum.com...
www.thenutritioncoach.com.au...

Use of Apan(a) Mudra:
www.youtube.com...
www.youtube.com...

Serrapeptase
serracor.wordpress.com...
serrapeptase.info...
serrapeptase.info...

Acupressure
www.youtube.com...
www.youtube.com...
www.youtube.com...

edit on Julpm17 11 20 by Rextiberius because: corrections




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