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originally posted by: M4ngo
Let me explain again: It is a fact that Metformin induces beta-amyloid aggregates.
So remember: Endocrinologists themselves published this in their International Journal:While metformin by itself increases the formation of Β-amyloid
This association was weakened after adjusting for serum vitamin B12 levels; thus any effect metformin has on cognitive performance may be at least partially mediated by altering serum vitamin B12 levels.
There was insufﬁcient information regarding the duration of metformin use, the severity ofdiabetes(e.g.,HbA1c levels), duration of diabetes, or use of other antidiabetic drugs to enable us to investigate these effects in our study, particularly because these ﬁndings were based on a small sample.
We recommend a larger study to examine the effect of dose and duration of metformin use, and the effects of other antidiabetic agents using a battery of cognitive assessments and following participants over a number of years.
originally posted by: TiredofControlFreaks
a reply to: dianajune
If you can afford it - there is a new drug called jardiance. Jardiance has the effect of weight loss and replaces insulin but it is a new drug so its expensive
Good luck with your pharmacist. please let me know how it has worked out.
You may also want to check out the local y to see if you can use their bike. Cycling is weightless and you may be able to manage it. Also the local community centre may offer some program for water aerobics.
You need exercise to stay off insulin
originally posted by: Rextiberius
a reply to: dianajune
Sorry to hear about your health woes. Try this: cut out all sources of unsaturated oil and never use them to cook your foods. This means not eating out, to avoid the unsaturated oils used in eateries... Small amounts of saturated oils like butter and coconut oils are fine. Take a Vit E cap of 300 - 400 IU daily (helps to repair the system damaged by unsaturated oils). Do not eat nuts as these often contain very high unsaturates; no fried foods of any kind and no fish oils too. Do this for a few months and see whether your diabetic condition will improve or not. Read up articles on the subject of "The Randle Cycle" to get a better understanding of the inhibition of glucose oxidation by unsaturated oils. Check your thyroid health status as well for it can be greatly compromised by chronic ingestion of unsaturated oils.
“As alleged, Novartis corrupted the prescription drug dispensing process with multi-million dollar ‘incentive programs’ that targeted doctors who, in exchange for illegal kickbacks, steered patients toward its drugs. And for its investment, Novartis reaped dramatically increased profits on these drugs, and Medicare, Medicaid, and other federal healthcare programs were left holding the bag, doling out millions of dollars in kickback-tainted claims,” said U.S. Attorney for the Southern District of New York Preet Bharara. “Healthcare fraud imposes tremendous costs and causes great harm to an already burdened healthcare system, and the government will not tolerate it. The widespread kickback fraud alleged in our two lawsuits against Novartis – which only a few years ago settled a False Claims Act case involving violations of the Anti-Kickback Statute based on illegal payments to doctors – makes us question whether Novartis is getting the message.”
FDA confirmed through laboratory analyses that your products “Diexi” and “Zoom” contain undeclared ingredients, metformin and sildenafil, respectively.
By marketing your products “Diexi” and “Zoom” as “all-natural,” “safe and effective” treatments with “no chemically generated compounds,” consumers are misled to believe your products do not bear unknown risks nor contain APIs found in approved prescription drugs. Accordingly, the failure to disclose the presence of metformin and sildenafil renders these products’ labeling false and misleading.
Furthermore, the undeclared ingredients in your products “Diexi” and “Zoom” cause your products to also be misbranded under section 502(f)(2) of the FD&C Act [21 U.S.C. § 352(f)(2)] in that their labeling lacks adequate warnings for the protection of users. As noted, there is potential for adverse events associated with the use of “Diexi” and “Zoom,” particularly since someone who takes them would be unaware of the presence of metformin and sildenafil, respectively.
In the presented case, we got an herbal medicine in the form of a set of different color pills from local herbal medicinal practitioner. According to the advertisements on monograph, the product contains only herbal ingredients without any adequate declaration of the ingredients and was declared as anti-diabetic formulation. For identification of the ingredients, the pills were analyzed by UV, IR and HPLC spectroscopy. One major ingredient was detected in the herbal pills and was identified as metformin hydrochloride.
Twenty-nine illicit herbal antidiabetic products were received from the 27 patients. Eight different, undeclared oral antidiabetic agents of various classes were detected. Glibenclamide, found in 22 out of the 29 products (76%), was the most frequent adulterated drug, followed by phenformin in 18 (62%), metformin and rosiglitazone in six products each (21%), gliclazide and glimepiride in two each (7%) and nateglinide and repaglinide in one each (3%).
Metformin is one of the most common adulterants found in anti-diabetic dietary supplements and herbal medicines.
Surface water from 38 streams nationwide was assessed using 14 target-organic methods (719 compounds). Designed-bioactive anthropogenic contaminants (biocides, pharmaceuticals) comprised 57% of 406 organics detected at least once. The 10 most-frequently detected anthropogenic-organics included eight pesticides (desulfinylfipronil, AMPA, chlorpyrifos, dieldrin, metolachlor, atrazine, CIAT, glyphosate) and two pharmaceuticals (caffeine, metformin) with detection frequencies ranging 66–84% of all sites.
The 10 most frequently detected anthropogenic-organic contaminants (not including cholesterol) were all designed-bioactive chemicals (Figure 3; Table 3). Eight were pesticides or pesticide degradates (desulfinylfipronil, AMPA [α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid], chlorpyrifos, dieldrin, metolachlor, atrazine, CIAT [deethyl atrazine], glyphosate), with detection frequencies ranging from 26 to 32 sites. Desulfinylfipronil (fipronil-insecticide degradate) was pervasive, occurring at 32 sites (84%). The broad-spectrum herbicide, glyphosate, or its common environmental degradate, AMPA (also potential organophosphonate degradate(56, 57)), was detected at 30 sites (79%). Likewise, the broad-spectrum herbicide, atrazine, or its environmental degradate, CIAT, was detected at 27 sites (71%). The remaining two were caffeine (28 sites, 74%) and the antidiabetic medication, metformin (25 sites, 66%).
Frequent detection of metformin (66% of sites) at median concentrations greater than 400 ng L–1, including seven sites with concentrations in the μg L–1 range, is noteworthy because metformin is a designed endocrine-active compound and effluent-equivalent metformin exposures in the μg L–1 range induce up-regulation of vitellogenin mRNA(88, 89) and male intersex(90) in fathead minnow (Pimephales).
The results presented herein provide the most extensive, target-polar-organic-chemical characterization of the composition and concentrations of contaminant-mixture exposures in streams available to date and support cross-examination of split-sample effects results (presented separately) as well as subsequent methods development, prioritization of future ecotoxicological studies of chemical mixtures, and in-silico modeling of potential biological effects of multiple contaminants.
A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the 14C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.
originally posted by: anonentity
a reply to: rickymouse
The Arizona University study, concluded that Apple Cider Vinegar was better than Metformin for lowering blood sugar. The Acetone in it makes acetone receptive gut bacteria flourish and stops the sugar. Especially the overnight readings. I threw out all the stuff the Doc gave me, watched my diet and took the Vinegar, got some exercise, thirty mins. a day walking. that was three years ago and I must admit it seems to work. This is of course anecdotal, but when diagnosed I was using honey to sweeten my coffee I think that was the main problem.