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A model has been constructed for the interaction of RuvA with its DNA target using a simple model of a Holliday junction in which the double-stranded B-DNA arms are held in a square-planar arrangement. The protein and junction have been docked manually maintaining colinearity of their respective fourfold axes. A good fit of the DNA onto the protein as judged by complementarity of their surface shapes and charges was observed when the axes of the DNA helical arms lay along the grooves in the concave surface of the protein. The pairs of parent and daughter duplexes are on opposite sides of the central pin which is positioned such that the strands of the incoming duplex DNA are encouraged to separate. The strands are then channelled into orthogonal grooves in the protein surface where they anneal with base pairs from the other incoming parent DNA duplex to form the outgoing daughter duplexes.
originally posted by: rickymouse
I like the little walking things. If these things are really walking and hauling things, there is more link than just the chemical signatures. Something makes them decide to move and signals the action, the chemicals actually cause the actions but something is still controlling them. We have electrical frequencies flowing through our bodies connecting everything together. Nerves are just a small part of it.
originally posted by: Devino
a reply to: dashen
How do those little things do that?
I get the feeling that there is more that we don't know than that which we do.
What is the driving force behind negative entropy and what is the nature of our connection to this force?
Here is a link to more from the 3-D Animation Library.
originally posted by: dashen
Its molecular clock work.
It all works on pressure and tension and chemical receptors and reactions
originally posted by: dr1234
We know exactly how every process shown works.