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Drug Widens Immunity to Flu
An immune suppressive drug can unexpectedly help immunized mice fight off many strains of flu.
The immunosuppressant drug rapamycin paradoxically helped to protect mice against a diverse range of influenza viruses after the animals were vaccinated against just one flu strain.
Rachael Keating from St. Jude Children’s Research Hospital said it seems that rapamycin steers immune cells away from producing antibodies that strongly target a particular flu strain, in favor of those that block a wide variety of strains. ...
“We’re definitely not advocating that we use rapamycin [in humans],” said McGargill. However, her group’s discovery could point to other ways of achieving the same effect, perhaps by manipulating the immune system into producing more cross-reactive antibodies. “Maybe instead of trying to enhance the immune response, we need to dampen it a little bit, and allow it to be more diverse,” she added.
Now, researchers have discovered that an immunosuppressant drug called rapomycin helps fight many flu strains when given with a vaccine. Quite a surprise as immunosuppressants suppress the immune response! So now scientists are thinking they need to dampen the immune response for a better effect
soficrow
One big problem with vaccines is that they leave the body defenceless against any flu strains not included in the mix. In comparison, a natural infection with flu triggers an immune response that provides broad immunity against other strains.....
“We’re definitely not advocating that we use rapamycin [in humans],” said McGargill. However, her group’s discovery could point to other ways of achieving the same effect, perhaps by manipulating the immune system into producing more cross-reactive antibodies. “Maybe instead of trying to enhance the immune response, we need to dampen it a little bit, and allow it to be more diverse,” she added.
katndew
So long story short.... I too will not be taking this if they come out with it. But once again, I don't get the flu due to my strong immune system, so I will just continue to keep it strong
The answer to solving the flu virus is in the beginning of the post where [sic]they acknowledge[/sic] that "a natural infection with flu triggers an immune response that provides broad immunity against other strains". ...
…I don't get the flu due to my strong immune system, so I will just continue to keep it strong
The cytokine storm (hypercytokinemia) is the systemic expression of a healthy and vigorous immune system resulting in the release of more than 150 known inflammatory mediators (cytokines, oxygen free radicals, and coagulation factors). …
It is believed that cytokine storms were responsible for many of the deaths during the 1918 influenza pandemic, which killed a disproportionate number of young adults.[1] In this case, a healthy immune system may have been a liability rather than an asset. Preliminary research results from Hong Kong also indicated this as the probable reason for many deaths during the SARS epidemic in 2003.[8] Human deaths from the bird flu H5N1 usually involve cytokine storms as well.[9] …
Into the eye of the cytokine storm.
Cytokine storms are associated with a wide variety of infectious and noninfectious diseases. The term was popularized largely in the context of avian H5N1 influenza virus infection, bringing the term into popular media.
Dynamics of a Cytokine Storm
This study illuminates details of a cytokine storm event, and it demonstrates the value of linear modeling for interpreting complex, coupled biological system dynamics from empirical data.
RE: "now scientists are thinking they need to dampen the immune response for a better effect"
Is it me or does not this statement fly in the face of common sense? Do they think that we are that stupid? I would say the answer to that is yes.
Unless of course, anybody can back up this claim.
soficrow
Now, researchers have discovered that an immunosuppressant drug called rapomycin helps fight many flu strains when given with a vaccine.
...Only problem was the reason why the young, healthy, and mostly military men were dropping dead was due to the fact it was the first time in history they were forced to get vaccines. ...
...If the strong, healthy ones start getting deathly ill again i'm sure it will be the ones that got the vaccines again.
Flu vaccines may help reduce the risk of being hospitalized for heart attacks, strokes or unstable angina, particularly in heart patients...