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Previous research has long focused on the association between cancer and individual microbes, a news release said.
But much recent attention has centered on the entire human microbiome, particularly in the gut, where more, and more diverse, communities of bacteria, viruses and fungi are found than anywhere else in or on the human body, the release said.
In lung cancers, for example, Blastomyces was associated with tumor tissues, the researchers involved in that study said. In stomach cancers, there were high rates of Candida; and in colon cancers, the presence of Candida helped predict the spread of disease.
The data arising from this research implicate mycobiota in the development of human gastrointestinal cancers and suggest that "tumor-associated fungal DNA may serve as diagnostic or prognostic biomarkers," the scientists said.
Highlights
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A pan-cancer analysis reveals human samples harbor tumor-associated mycobiota
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Fungal genome coverage analysis removes contamination and false-positive alignments
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Alive, transcriptionally active Candida is associated with gastrointestinal cancers
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Candida DNA is enriched in tumors and predictive of reduced survival in GI cancers
Summary
Highlights
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Fungi were detected in 35 cancer types and were often intracellular
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Multiple fungal-bacterial-immune ecologies were detected across tumors
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Intratumoral fungi stratified clinical outcomes, including immunotherapy response
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Cell-free fungal DNA diagnosed healthy and cancer patients in early-stage disease
originally posted by: musicismagic
SADLY there are many different types of cancer.