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apnews.com...:-US-scientists-try-1st-gene-editing-in-the-body
OAKLAND, Calif. (AP) — Scientists for the first time have tried editing a gene inside the body in a bold attempt to permanently change a person’s DNA to cure a disease.
The experiment was done Monday in California on 44-year-old Brian Madeux. Through an IV, he received billions of copies of a corrective gene and a genetic tool to cut his DNA in a precise spot.
Signs of whether it’s working may come in a month; tests will show for sure in three months.
If it’s successful, it could give a major boost to the fledgling field of gene therapy . Scientists have edited people’s genes before, altering cells in the lab that are then returned to patients. There also are gene therapies that don’t involve editing DNA.
“We cut your DNA, open it up, insert a gene, stitch it back up. Invisible mending,” said Dr. Sandy Macrae, president of Sangamo Therapeutics, the California company testing this for two metabolic diseases and hemophilia. “It becomes part of your DNA and is there for the rest of your life.”
That also means there’s no going back, no way to erase any mistakes the editing might cause.
“You’re really toying with Mother Nature” and the risks can’t be fully known, but the studies should move forward because these are incurable diseases, said one independent expert, Dr. Eric Topol of the Scripps Translational Science Institute in San Diego.
originally posted by: seasonal
a reply to: sine.nomine
If the option was death, I could justify it and grow the courage.
I would imagine the patient feels like crap, is in pain, suffering and must know the next step is death. So what is there to loose?
originally posted by: Winterpain
a reply to: rickymouse
I agree there is risk, but for so many people there is no choice or current hope.
If the people are willing, I don't see the harm? If it doesn't work, the willing patient may be harmed/killed, but it was there one chance to be normal/healthy and their choice. If it does work, they may be cured, and humanity a step closer to help thousands.
Just my 2 cents.
~Winter
originally posted by: madmac5150
Can they edit my genes so they don't shrink in the dryer the first time they are washed?
That would really be something...
originally posted by: rickymouse
originally posted by: madmac5150
Can they edit my genes so they don't shrink in the dryer the first time they are washed?
That would really be something...
Maybe it would be safer for these scientists to work on that than monkeying with our most critical system in our body.
To edit genes, you would have to edit all the genes in the body. How are they going to accomplish that, stem cells travel throughout the body regularly.
originally posted by: andy06shake
a reply to: rickymouse
That won't stop science progressing in the field.
Even if it's in some black budget facility off the books, if it can be done, then it probably is being done.