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Grimpachi
PERSPECTIVE
According to Schaffner, studies have showed the flu vaccine to be about 40 percent effective overall in the elderly. He expressed optimism to CBSNews.com in January because the H3N2 influenza A strain the committee selected prior to the start of the flu season was a "bull's-eye hit" for the strain causing most of the illnesses this year. That remains true, he said Thursday, which is why today's findings in seniors were so puzzling.
As dismal as the numbers looked, he said, there needs to be perspective. The vaccine was still 27 percent effective overall for seniors over 65 years. For that age group, there aren't other preventive disease-fighting approaches as effective, he said. He also added that the better protection rates reported in children and adults under 65 suggest people in those age groups were less likely to give influenza to older people.
"You have to add in all the benefits before you give the influenza vaccine a thumbs down," said Schaffner.
Flu surveillance reports released by the CDC in recent months have shown adults 65 and older account for more than half of the Americans who have been hospitalized because of the flu.
27% > 0%
as even Dr.'s at the WHO have admitted they are pointless profit machines.
So the above statement that was made was not factual?
The doctors linked to in this article do not work for the WHO, but if you start checking for the rates by year and look up the doctor's pedigree it is a very simple task.
?????
Dr.'s at the WHO have admitted they are pointless profit machines.
Grimpachi
reply to post by FriedBabelBroccoli
I understand Schaffner never worked for the WHO, but you left out the part that put things into perspective. 27% effectiveness is better than 0% effectiveness with that strain. I hope you agree. I never insinuate that unvaccinated people have no immunity.
An additional finding was that the vaccine did not seem to protect participants who were exposed to flu in their own household, though the numbers in that arm of the study were small.
Researchers from the US Centers for Disease Control and Prevention and the University of Hong Kong collaborated with University of Michigan researchers on the study, with Suzanne E. Ohmit, DrPH, of Michigan as the lead author.
The findings come amid a growing number of studies that raise questions about flu vaccine effectiveness (VE). They include, among others, last week's CDC report that this year's vaccine has worked poorly in elderly people and three recent European studies showing that vaccine-induced immunity in the 2011-12 season waned after 3 to 4 months. Other studies have cast doubt on the long-standing belief that a close match between the vaccine virus strains and circulating strains improves VE.
Results. The pooled effectiveness of vaccine against hospitalizations for acute respiratory disease was 21% (95% confidence interval [CI], 17%–26%). The rate reduction attributable to vaccination was 4.15 hospitalizations/100,000 person-weeks in the influenza season. Among vaccine recipients, no important reduction in the number of admissions to the hospital was seen outside influenza seasons. The pooled effectiveness of vaccine against deaths due to respiratory disease was 12% (95% CI, 8%–16%). A greater proportionate reduction was seen among people without medical disorders, but absolute rate reduction was higher in individuals with medical disorders, compared with individuals without such disorders (6.14 deaths due to respiratory disease/100,000 person-weeks vs. 3.12 deaths due to respiratory disease/100,000 person-weeks). Clear protection against death due to all causes was not seen.
. . .
Among the 125 people who tested positive for flu, 59% had been vaccinated at least 14 days before their illness onset, long enough for an immune response. The infection risk in the vaccinated people was 8.5% (74 of 866), versus 8.9% (51 of 575) in the unvaccinated individuals.
Results
During weeks when 5% of respiratory specimens tested positive for influenza A, vaccine effectiveness among persons aged ≥65 years was 22% (95% confidence interval [CI], −6%–42%) for all influenza-associated deaths, 25% (95% CI, 13%–37%) for deaths occurring within 30 days after an influenza-associated pneumonia/influenza hospitalization, and 19% (95% CI, 4%–31%) for influenza-associated pneumonia/influenza hospitalizations. Because small proportions of deaths, deaths after pneumonia/influenza hospitalizations, and pneumonia/influenza hospitalizations were associated with influenza virus circulation, we estimated that vaccination prevented 1.6%, 4.8%, and 4.1% of these outcomes, respectively.
Conclusions
By using confounding-reducing techniques with 15 years of provincial-level data including vaccination and health outcomes, we estimated that influenza vaccination prevented ~4% of influenza-associated hospitalizations and deaths occurring after hospitalizations among older adults in Ontario.
As dismal as the numbers looked, he said, there needs to be perspective. The vaccine was still 27 percent effective overall for seniors over 65 years. For that age group, there aren't other preventive disease-fighting approaches as effective, he said.
???
Dr.'s at the WHO have admitted they are pointless profit machines.
As an interactive map from the Council on Foreign Relations illustrates, several diseases that are easily prevented with vaccines have made a comeback in the past few years. Their resurgence coincides with changes in perceptions about vaccine safety. link
.......MMR...DTP/Dtap----Polio------Hib--------§ HepB
2008- 92.1---96.2-----------93.6-----90.9--------93.5
2009- 90-----95--------------92.8-----54.8--------92.4
2010- 91.5---95--------------93.3-----66.8-------91.8
2011- 91.6---95.5-----------93.9------80.4-------91
2012- 90.8---94.3-----------92.8------80.9-------89.7
How are benefits of vaccination measured?
Public health researchers measure how well flu vaccines work through different kinds of studies. “Randomized studies,” in which people are randomly assigned to receive either vaccine or placebo (i.e., salt water solution), and then followed to see how many in each group get the flu, are the “gold standard” (best method) for determining how well a vaccine works. The effects of vaccination measured in these studies is called “efficacy.”
“Observational studies” are studies in which subjects who choose to be vaccinated are compared to those who chose not to be vaccinated. This means that vaccination of study subjects is not randomized. The measurement of vaccine effects in an observational study is referred to as “effectiveness.” Randomized studies are expensive and are not conducted after a recommendation for vaccination has been issued, as withholding vaccine from people recommended for vaccination would place them at risk for infection, illness and possibly serious complications. For that reason, most U.S. studies conducted to determine the benefits of flu vaccination in the elderly are observational studies.
How does CDC present data on flu vaccine effectiveness?
CDC typically presents vaccine effectiveness (VE) as a single point estimate: for example, 60%. This point estimate represents the reduction in risk provided by the flu vaccine. CDC vaccine effectiveness studies commonly measure laboratory confirmed flu illness that results in a doctor’s visit or urgent care visit as an outcome. For this outcome, a VE point estimate of 60% means that the flu vaccine reduces a person’s risk of developing flu illness that results in a visit to the doctor’s office or urgent care provider by 60%.
In addition to the VE point estimate, CDC also provides a “confidence interval” (CI) for this point estimate, for example, 60% (95% CI: 50%-70%). The confidence interval provides a lower boundary for the VE estimate (e.g., 50%) as well as an upper boundary (e.g., 70%). One way to interpret a 95% confidence interval is that if CDC were to repeat this study 100 times, 95 times out of 100, the VE point estimate would fall within the confidence interval (i.e., on or between 50% and 70%). There is still the possibility that five times out of 100 (a 5% chance) that CDC’s point estimate of VE could fall outside of the 50%-70% confidence interval.
This is further evidenced by your refusal to stay on the topic
At least mandatory influenza vaccination is not on the list as even Dr.'s at the WHO have admitted they are pointless profit machines. www.abovetopsecret.com...
influenza vaccination is not on the list as even Dr.'s at the WHO have admitted they are pointless profit machines.
Grimpachi
reply to post by FriedBabelBroccoli
This is further evidenced by your refusal to stay on the topic
You know I am real glad you wish to stay on topic because we seem to be drifting away from the question that was asked of you.
This thread wasn't about influenza however you did bring it up when you said.
At least mandatory influenza vaccination is not on the list as even Dr.'s at the WHO have admitted they are pointless profit machines. www.abovetopsecret.com...
To which the question has been asked several times if you can corroborate your claim that
influenza vaccination is not on the list as even Dr.'s at the WHO have admitted they are pointless profit machines.
Can you please stop deflecting attention away from the question and answer.
The thread wasn't about influenza, but you made a statement which I think you simply made up. I figured you were done so I went back in line with the thread but please if Dr's at the WHO actually are saying those things I want to know.
Come now pots shouldn't be antagonizing kettles.edit on 28-3-2014 by Grimpachi because: (no reason given)
If you've been diagnosed "probable" or "presumed" 2009 H1N1 or "swine flu" in recent months, you may be surprised to know this: odds are you didn't have H1N1 flu.
In fact, you probably didn't have flu at all. That's according to state-by-state test results obtained in a three-month-long CBS News investigation.
The ramifications of this finding are important. According to the Centers for Disease Control and Prevention (CDC) and Britain's National Health Service, once you have H1N1 flu, you're immune from future outbreaks of the same virus. Those who think they've had H1N1 flu -- but haven't -- might mistakenly presume they're immune. As a result, they might skip taking a vaccine that could help them, and expose themselves to others with H1N1 flu under the mistaken belief they won't catch it. Parents might not keep sick children home from school, mistakenly believing they've already had H1N1 flu.
. . .
In late July, the CDC abruptly advised states to stop testing for H1N1 flu, and stopped counting individual cases. The rationale given for the CDC guidance to forego testing and tracking individual cases was: why waste resources testing for H1N1 flu when the government has already confirmed there's an epidemic?
. . .
CBS News learned that the decision to stop counting H1N1 flu cases was made so hastily that states weren't given the opportunity to provide input. Instead, on July 24, the Council for State and Territorial Epidemiologists, CSTE, issued the following notice to state public health officials on behalf of the CDC
Dr.'s at the WHO have admitted they are pointless profit machines.
Grimpachi
reply to post by FriedBabelBroccoli
Because I have not read anything you linked that stated as you have that
Dr.'s at the WHO have admitted they are pointless profit machines.
If I missed it apologies however I don't think I missed a statement such as that. I have never seen you miss a chance at proving a point so I am inclined to think you never linked it.
If such a statement from Dr's at the WHO exists I would like to see it. If you cant be bothered to quote and link the info then I think my inclination is probably correct. Seeing as how from the start I searched looking for info to back up your statement to no avail the odds are less than what you get with a coin toss of it being true.edit on 28-3-2014 by Grimpachi because: (no reason given)
"Our bottom line is that immunization is the most effective single thing you can do to protect yourself [from flu], and this isn't going to change what we say," Nicoll said. But he added, "It's an important finding, and this does now need to be looked at in the longer term and a larger cohort."
Influenza vaccination reduces the number of hospitalizations and deaths due to respiratory disease, after correction for confounding in individuals > years of age who had a high risk or a low risk for influenza. For elderly people, untargeted influenza vaccination is of confirmed benefit against serious outcomes.
By using confounding-reducing techniques with 15 years of provincial-level data including vaccination and health outcomes, we estimated that influenza vaccination prevented ~4% of influenza-associated hospitalizations and deaths occurring after hospitalizations among older adults in Ontario.
Even if the vaccine provides less protection in older adults than it might in younger people, some protection is better than no protection at all, especially in this high risk group......... While the protection elderly adults obtain from flu vaccination can vary significantly, a yearly flu vaccination is still the best protection currently available against the flu.........There are limited data to suggest that flu vaccination may reduce flu illness severity; so while someone who is vaccinated may still get infected, their illness may be milder........... Although flu vaccine is not perfect, the overall evidence supports the public health benefit of flu vaccination. Vaccination is particularly important for people 65 and older who are especially vulnerable to serious illness and death, despite the fact that the vaccine may not work as well in this age group.... Recent studies show vaccine can reduce the risk of flu illness by about 60% among the overall population during seasons when most circulating flu viruses are like the viruses the flu vaccine is designed to protect against.
Because of the uncertainties, the CDC advises even those who were told they had H1N1 to get vaccinated unless they had lab confirmation. "Persons who are uncertain about how they were diagnosed should get the 2009 H1N1 vaccine."
Where did I say that article was what you are claiming?
Oh wait . . . I didn't . . .
Grimpachi
reply to post by FriedBabelBroccoli
Where did I say that article was what you are claiming?
Oh wait . . . I didn't . . .
Those are quotes from all the articles you posted. loledit on 28-3-2014 by Grimpachi because: (no reason given)
I did not commit the entirety of each article to memory and assumed
Your selective cut and paste efforts are cute though.
You also realize you are supporting mandatory vaccination of the entire population (as you stated previously)
Should I link you to the other studies
Dr.'s at the WHO have admitted they are pointless profit machines.www.abovetopsecret.com...
You did say you don't see any reason not to mandate the flu vaccine.
You are either desperate, trying to troll me, or simply don't understand what you are quoting
At least mandatory influenza vaccination is not on the list as even Dr.'s at the WHO have admitted they are pointless profit machines.
Since Croatia made vaccinations universal in 1999 diphtheria, whooping cough and measles have disappeared entirely and tuberculosis has decreased by 93%, tetanus by 97% and hepatitis B by 65%.
Possibly because of this success, however, Croatia has experienced substantial resistance to what was once an uncontroversial policy. Having achieved universal vaccination for a decade (presumably excluding cases where there was a valid medical reason) 28 children went unvaccinated in 2012, according to official records, and in 2013 this climbed to 143. While these numbers are not enough to generate the sorts of outbreaks seen in the US and UK as a result of campaigns by anti-vax lobbyists, the direction is clear.
The potential scale of the revolt is indicated by 10,000 people signing a petition claiming, "the vaccination of healthy children poses a threat to their health." Inevitably the law was challenged in court, but the highest court in the land has now endorsed it. The decision has been hailed by the Croatian Medical Association and the Croatian Institute for Public Health.
The implications of a let up in vaccination regimes can be seen in Syria where the war has interrupted the childhood immunization program. As a result polio, recently confined to just three countries, is now spiraling out of control in Syria. Children, including those who make it to refugee camps in surrounding countries, are being sentenced to lifelong paralysis.
Read more at www.iflscience.com...
Grimpachi
Back on topic
Let us hope that one day the world will be free of preventable diseases.
In June 1991, Croatia declared independence, which came into effect on 8 October of the same year. The Croatian War of Independence was fought successfully during the four years following the declaration.
The Croatian Immunology Institute has entered administration and fired all of its workers – some 200 people, including research staff – despite being a profitable biotech firm with around 20 drugs and vaccines sold internationally.
The institute announced it was going into administration on 8 January, with an ensuing media furore and allegations of political corruption. Some claimed that the state was attempting to sell off parts of this key national asset that also makes discounted drugs and vaccines for the local market.
A long-term lack of investment in technology and premises in the capital Zagreb cost the institute first its World Health Organization (WHO) licence in 1998, and then its Croatian national drug agency licence to manufacture blood derivatives and bacterial vaccines last summer. These two products accounted for almost 80% of its profits in the last two years or around €5.7 million (£4.7 million) in 2012.
Ivan Tomac, president of a Croatian power and chemistry union, tells Chemistry World 'the Institute of Immunology has been neglected and outdated in terms of personnel, finance, organisation and technology'. Lack of investment and action from management meant that 'each year the institute sank deeper and deeper [into debt], which culminated in the loss of the production licence' for blood derivatives and bacterial vaccines last year.
. . .
The institute has faced difficulties ever since its partial privatisation in 1993, with the government maintaining 50% of shares. The number of employees has halved since 1991. In 1998, because its premises did not meet safety requirements it lost its WHO licence, but continued exporting products to countries that did not require this.
The institute has since declared bankruptcy, given that most of its revenues were tied to it having the licences to manufacture and sell those products. But this was later annulled by a court and it is now undergoing restructuring and searching for private investors to allow it to restart some production. It has changed three directors in the last couple of months.
The institute’s downfall has been widely seen as a consequence of neglect by its majority shareholder, the Croatian government, and the government’s failure to invest in new technologies and infrastructure.
Vlatko Silobrčić, a fellow of Croatia’s science academy, who was director of the institute from 1992-1997, says the key problem of lack of investment in technology has plagued the organisation for years.
“Nothing concrete really changed [after I left],” he says. “Five management and supervisory boards changed, but the government still neglected its own role.”
Sci Dev Net 10/02/14
At least two Croatia-based pharmaceutical firms have expressed an interest in investing in and partnering with the institute: PharmaS and Jadran Galenski Laboratorij, and media reports have also said there was interest from Biognost (Croatia), Grifols (Spain) and Octapharma (United Kingdom).
Vlatko Silobrčić, a fellow of Croatia’s science academy, who was director of the institute from 1992-1997, says the key problem of lack of investment in technology has plagued the organisation for years.
“Nothing concrete really changed [after I left],” he says. “Five management and supervisory boards changed, but the government still neglected its own role.”
The institute’s key focus was on making medicinal blood derivatives, antitoxins and vaccines against bacterial and viral diseases.
Its products included vaccines for measles, mumps, rubella, tetanus, diphtheria and meningitis A — and a rabies treatment.
. . .
As recently as last August, the institute signed a deal with HLL Biotech, a subsidiary of Indian government enterprise HLL Lifecare, to provide measles vaccines and technology transfer to enable the production of 80 million doses for the Indian market and possibly for China and other Asian countries.
FriedBabelBroccoli
reply to post by Grimpachi
A body rejected by the WHO is producing vaccines for decades and you are okay with that?
You do realize this is the same government running the facility in partnership with private interests that just declared the mandatory vaccination schedule after its corporation couldn't find enough investors?
These are the people in charge of public health?
www.scidev.net...
Vlatko Silobrčić, a fellow of Croatia’s science academy, who was director of the institute from 1992-1997, says the key problem of lack of investment in technology has plagued the organisation for years.
“Nothing concrete really changed [after I left],” he says. “Five management and supervisory boards changed, but the government still neglected its own role.”
The institute’s key focus was on making medicinal blood derivatives, antitoxins and vaccines against bacterial and viral diseases.
Its products included vaccines for measles, mumps, rubella, tetanus, diphtheria and meningitis A — and a rabies treatment.
. . .
As recently as last August, the institute signed a deal with HLL Biotech, a subsidiary of Indian government enterprise HLL Lifecare, to provide measles vaccines and technology transfer to enable the production of 80 million doses for the Indian market and possibly for China and other Asian countries.
I am curious if you are aware of the current WHO license status of these other vaccine producers?
If so, why not produce your source and set a good example?
-FBB