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The crash caused at least two explosions, throwing debris across the area. Emergency officials at the scene say the plane is still burning. A plume of smoke is rising from the site, as fire trucks and other emergency vehicles are lined up on a road nearby. The Federal Aviation Administration said the A300 plane - en route from Louisville, Kentucky, to Birmingham - crashed on approach to the airport before dawn.
Local reports say two people were aboard the plane, but there was no immediate information on them.
Reports say the plane went down on the outskirts of Birmingham-Shuttlesworth International Airport, in an open field that is just outside the perimeter fence of the airport.