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About half of all people taking selective serotonin reuptake inhibitors (SSRIs) like Zoloft experience sexual dysfunction such as loss of libido or anorgasmia, and as many as 90 percent go off their meds because of it, say researchers. That's a lot of lost patients.
Viagra, works by inhibiting "cGMP catabolism" in the smooth muscle tissue of the clitoris and penis, which enhances the "cGMP activity" that enables tissue to respond to sexual stimulation -- possibly even when serotonin-altered, as is the case with women on antidepressants.