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IgG4-related disease (IgG4-RD) is a newly classified, immunological condition. It involves potentially multi-organ inflammation and fibrosis, characterized (in most cases) by elevated serum IgG4 levels and presenting as tissue edema with fibrosis and marked inflammatory infiltration of IgG4-positive plasma cells. IgG4-RD constitutes a number of conditions previously classified separately according to the organ affected, therefore, it occurs in various forms: autoimmune pancreatitis type 1 (AIP1), Mikulicz’s disease (MD), dacryoadenitis, sclerosing cholangitis, lymphadenopathy, and – less commonly – retroperitoneal fibrosis, Riedel’s thyroiditis, sclerosing sialadenitis (Kuttner’s tumor), and interstitial lung or kidney disease.
By now, you have probably heard about the Science Immunology paper showing that people who have received mRNA Covid vaccines produce more of an unusual antibody called IgG4 over time. A number of mRNA skeptics, including me, wrote about it last week.
But the reasons why the paper is so troubling may still not be clear. So here’s a (with luck) digestible explanation, starting with what is probably the most important question: what’s the worst-case scenario?
1: What’s the worst-case scenario?
Glad you asked.
The worst-case scenario: the mRNA shots lead to a doom loop, robbing vaccinated people of a crucial immune system tool against the coronavirus in a way that worsens with each new infection.
Thus, over time, the average severity of Covid infections will increase. People will take longer to get better once they’re infected. Hospitalizations and deaths will rise. The health-care system will come under worsening strain.
originally posted by: Subrosabelow
I only got the initial 2 shots myself. No boosters. I ended up with a nasty case of covid last year. I've been sick twice more since then. I didn't test for Covid, but all the same symptoms were there again each time. I just got over the last bout and still have a persistant cough nearly 2 weeks later.
I hadn't had the flu or any such illness since I was in college, nor have I ever been vaxxed for the flu. That was decades ago. Until now. Now, three times in two years, Covid has kicked my butt.