Supply Chain Breakage in Big Pharma

Little background....

Supply chains are breaking down. There has been a serious shift that I have noticed in the production of heart disease medication. Big pharma is shifting focus to their high profit yield, zero liability vaccine scam.

Now... The wife has Hypertrophic Cardiomyopathy and can't take the jab or she'll die from the additional increase in intensity of Myocarditis plus the resulting systemic organ damage caused by the endothelial feathering. It's pretty serious, she has been in the hospital 5 times with congestive heart failure. That would be the initial event in 2018, plus 2 caused directly through negligence and stupidity by Southlake Hospital in Newmarket, one caused by her TGH doctor in 2019 (Amiodarone+Rythmodan(Disopyramide)) and one caused by a change in medication by her doctor at TGH recently reducing Disopyramide and increasing Bisoprolol (2021). She is on a sodium channel blocker called Disopyramide, which is out-of-stock everywhere in pharmacies and drug companies. She was taken off an iodine based potassium channel blocker called Amiodarone because it had induced ILS (Interstitial Lung Disease), possibly because of the Amiodarone (it is a potential side effect) or by the combination with Disopyramide (again a TGH doctor problem from 2019).

Her heart doctor is pretty loopy these days, the 5th floor heart disease clinic in Toronto General Hospital have gone stupid, her idiot specialist cardiac doctor actually suggested she take the covid jab, even though she knows obviously that my wife has cardiomyopathy. I have told her doctors to be very careful, what they do to her, will happen to them one way or another. If she runs out of Disopyramide she will die and of course I am trying to prevent that from happening.

So we get down to business.... I am looking for a reliable chemical supplier in Canada that can supply Disopyramide in bulk, 50g to 1kg at a reasonable cost. I have lab equipment, can make a clean room, can buy an HPLC and mass spec if I have to, to double check purity (years ago, in my 20's, I was regional engineer and used to design analytical instrumentation systems for one of the big fortune 500 companies). I can buy the *0 or *00 gel caps for around $50 us/10,000 and certainly, 1kg of Disopyramide will yield 10,000 100mg doses. I am getting low prices out of China of less than $100usd/kg and up to $1257usd/50g in the US which seems a bit steep. Obviously the supplier has to be certified, registered, the Disopyramide at 99.9%+ medical grade and usable on human subjects.

Since we are seeing supply chain breakdowns and these idiot big pharma companies shifting towards zero liability fraudulent vaccine production, what I am doing here might help others in the future by laying down a template for localized production of meds that have been dropped due to "profitability" issues.

You can use the link at Molbase to find almost any drug or chemical.[SNIPPED]
Disopyramide Link at MolBase
Bulk Capsules

Cheers - Dave

a reply to: bobs_uruncle

I am sorry to hear about your wife's problems. It is also important that she does not get the virus too, because that will also probably cause some heart issues to get worse.

Hopefully the omicron variant does not have the same heart problems issues as the previous variants, it supposedly is more of an airway issue than damaging everything else in the body. But with her issues it is important to take precautions. I am glad the doctor advised her not to get vaccinated.

The problem is that going to the hospital for tests and the doctors offices also increases risk of getting the virus because there are lots of people going to those places when they are sick and may have this virus.

Your situation sucks....sorry about being so outright, but I am thinking outloud on the keyboard. I hope she gets through this without winding up in the hospital or dying. It also effects you quite a bit because you don't want to bring it home either when you are out and about and because she is at more risk that means you need to be out more. Again, that sucks

Someone just told me I was being to morbid in my post talking about comorbidity...with a little smiley face. But here I am now talking about something morbid. I sure hope you two get through this all right.

a reply to: bobs_uruncle

Kudos to you if you can pull that off


At the same time: dude what a #ed up state of affairs

a reply to: bobs_uruncle

Why is she on Disopyramide vs Amiodarone?

a reply to: bobs_uruncle

I watched a great video on this topic a couple hours ago. Some interesting comments from viewers also. The video is around 15 minutes long from the channel A Call For An Uprising. Really good content in most of his videos.


youtu.be...

If you cannot get the medication, maybe this info will help you to find an alternate treatment. Maybe reducing the medication you have left plus inhibiting it's breakdown might work. You would have to discuss this with your doctor though, I do not think grapefruit juice by itself would have enough ability to treat the condition, and I am not sure from your information what is the exact reason she needs the medicine. Grapefruit consumption would stop the medication from being broken down, so possibly it might be able to help lessen the dose need too...but you would have to discuss this with your doctor.

medicalxpress.com...

I would think there would be a different medicine around that would be antiarithmatic they could change her to though.

originally posted by: rickymouse
a reply to: bobs_uruncle

I am sorry to hear about your wife's problems. It is also important that she does not get the virus too, because that will also probably cause some heart issues to get worse.

Hopefully the omicron variant does not have the same heart problems issues as the previous variants, it supposedly is more of an airway issue than damaging everything else in the body. But with her issues it is important to take precautions. I am glad the doctor advised her not to get vaccinated.

The problem is that going to the hospital for tests and the doctors offices also increases risk of getting the virus because there are lots of people going to those places when they are sick and may have this virus.

Your situation sucks....sorry about being so outright, but I am thinking outloud on the keyboard. I hope she gets through this without winding up in the hospital or dying. It also effects you quite a bit because you don't want to bring it home either when you are out and about and because she is at more risk that means you need to be out more. Again, that sucks

Someone just told me I was being to morbid in my post talking about comorbidity...with a little smiley face. But here I am now talking about something morbid. I sure hope you two get through this all right.

If you are talking about covid as a virus, it was extinct summer of 2020. All that is left is natural influenza, norovirus, rhinovirus and coronavirus. Yes, she has a comorbidity that the jab, which produces the spike protein, will kill her. Of course that spike protein will kill everyone who has taken the jab, it's called accelerated death via systemic decrease in organ efficiency. I only list her conditions as they apply to supply chain and pharma shortages due to the present production divergence caused by greed and megalomania generated in the fraudulent vaccine arena.

My issue is trying to source either medical grade disopyramide or locating the process/formula and I'll make it myself ;-)

Cheers - Dave

a reply to: rickymouse

Grapefruit juice is a HUGE no no with that medication. Absolutely do not mix the two. It could actually be lethal.

originally posted by: OccamsRazor04
a reply to: bobs_uruncle

Why is she on Disopyramide vs Amiodarone?

As an Iodine based potassium channel blocker, it has propensity to shed iodine in untoward places, specifically the lungs, eyes and thyroid gland. So it can produce a number of serious side effects. It has mildly effected her eyes and produced some hyperthyroidism, however its main side effect for her is the stiffening of the interstitial membrane, or causing interstitial lung disease. The stiffening prevents the lungs from expanding and contracting, it's like interstitial fibrosis, so the patient literally can't breath even using something like an artificial lung system. I caught the problem in the hospital and told her doctors to get her the f**k off if it, they did and with just disopyramide she's been pretty good. No incidents until her doctor at TGH dropped the disopyramide dosage and increased the bisoprolol. Then she was back in the hospital again with another bout of congestive heart failure.

Each time her troponin levels go through the roof, each time it's more heart damage. Couple this with an excessive pressure gradient across her lungs well in excess of 50mmg and any change can make sh!t go sideways. I have to be on top it it all the time. The start is always arrhythmia so I have SPO2 and an ECG monitor on her pretty much all the time. She's fully functional, she an ICD but she has to be careful and this covid BS is really pissing her off. She's a trooper though, she actually had a probe put into her neck and into her carotid artery to measure cardiovascular lung pressure and she didn't pass out.

Cheers - Dave

a reply to: bobs_uruncle
Sorry to hear that, I hope you can find what you need.

originally posted by: Illumimasontruth
a reply to: bobs_uruncle

I watched a great video on this topic a couple hours ago. Some interesting comments from viewers also. The video is around 15 minutes long from the channel A Call For An Uprising. Really good content in most of his videos.


youtu.be...

We are going to see increasing shortages. Some will starve to death, some will fight and be killed over resources. It's all part of the depop plan. They have to kill off healthy people to reduce the resistance. It standard warfare tactics, get the other side to fight within their own ranks to reduce opposition. Anybody with a military, CI past or common sense can see where this is going. As soon as I saw the MIC was looking to kill 230 million americans and 11 million canadian I knew exactly why. There are way more guns in the US than Canada, the US will fight, Canada will capitulate.

Cheers - Dave

a reply to: bobs_uruncle
different language search
Translation barrier though.👍

If just the formula is sought I am hoping ya can get what you're looking for.

I went this route looking for a pulse width modulator (found in china) since at the time unavailable in us market.
🙏❤ to you and yours!





image search


Gimme a sec to upload a pic for ya...

originally posted by: rickymouse
If you cannot get the medication, maybe this info will help you to find an alternate treatment. Maybe reducing the medication you have left plus inhibiting it's breakdown might work. You would have to discuss this with your doctor though, I do not think grapefruit juice by itself would have enough ability to treat the condition, and I am not sure from your information what is the exact reason she needs the medicine. Grapefruit consumption would stop the medication from being broken down, so possibly it might be able to help lessen the dose need too...but you would have to discuss this with your doctor.

medicalxpress.com...

I would think there would be a different medicine around that would be antiarithmatic they could change her to though.

Thanks, will look at it, but reducing the medication was what put her in the hospital with congestive heart failure again. I can buy disopyramide, but only 98% from the US at $1257usd/50g, that's enough for 500 doses at 100mg or 250 days. I don't mind paying it if it helps her, I am concerned about the purity, so I am also looking for the process/formula to produce the drug myself in my own lab and that's just for her, I am not planning on mass producing. The problem is what happens if she dies? In simple terms, I come off my leash, which I have only stayed on for her, nobody wants that. I have gotten use to not being what I was, I've been a good "boy" for 32 years, but you never forget how to ride a "bike."

Bit frustrated right now...., but I always make a plan ;-)

Cheers - Dave

originally posted by: loveguy
a reply to: bobs_uruncle
different language search
Translation barrier though.👍

If just the formula is sought I am hoping ya can get what you're looking for.

I went this route looking for a pulse width modulator (found in china) since at the time unavailable in us market.
🙏❤ to you and yours!

image search

In the image that's the stuff, if change C21H32N3O to C21H32N3O5P you get disopyramide phosphate which might also work. I have a message in to a pharmacist to find out....

Here's the non .ru link Disopyramide

Cheers - Dave

a reply to: bobs_uruncle

Usually it's the opposite, Amiodarone tends to have fewer and milder side effects, but in medicine everyone reacts different.

a reply to: bobs_uruncle
Thought it worth a try...if in Japan with a shovel and know what to look for...

Avermectins are a family of 16-membered macrocyclic lactones isolated from Streptomyces avermitilis7. The family consists of eight components with similar chemical structures (designated A1a, A1b, B1a, B1b, A2a, A2b, B2a, B2b). Though all the avermectins have nematocidal, acaricidal and insecticidal activity combined with low toxicity to mammals, the B-series components have been proven to be more active than the A-series7

clay soil

🙋

originally posted by: OccamsRazor04
a reply to: bobs_uruncle

Usually it's the opposite, Amiodarone tends to have fewer and milder side effects, but in medicine everyone reacts different.

It's a good point, Amiodarone is usually well tolerated. I would have thought that's how it would work out as well, because the Thyroid uses iodine and the wife is on a low salt diet, so lower levels of potassium iodide, there should be reasonable uptake in the thyroid gland. However, her screwed up 5th floor TGH doctor decided to give her Rythmodan (disopyramide) on top of a slightly lowered dose of Amiodarone. The lowered Amiodarone dosage should have reduced any probability of iodine retention, especially in the lungs and eyes. It is possible that the three months on both meds created the problem of iodine retention in the lungs creating the ILD. Maybe there is some target that disopyramide paints on the interstitial membrane to draw in Iodine, I don't know about that one?

ETA: It is possible that the added toxicological pressure of disopyramide on the liver and kidneys, might have made it so the iodine was kept in circulation and not filtered, and removed.

Cheers - Dave

I was thinking along the line of an early 20th century apothecary lab producing natural treatments from old recipes and formulations.