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Today, the Centers for Disease Control and Prevention (CDC)’s Division of Select Agents and Toxins published an Interim Final Rule adding SARS-CoV/SARS-CoV-2 chimeric viruses resulting from any deliberate manipulation of SARS-CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors to the list of HHS select agents and toxins. In addition, the work to create this chimeric virus is a ‘restricted experiment’ and requires prior approval from CDC before performing the experiment.
The regulation, available at www.federalregister.gov... icon, was published in the Federal Register and CDC will be accepting public comments on the addition of the agent for the next 60 days.
HHS/CDC believes that immediate regulatory oversight of these experiments and the resulting chimeric viruses is essential to protect the public from the potential consequences of a release of these viruses.
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chi·mer·ic (kī-mĕr′ĭk, -mîr′-)
adj.
1. Relating to or being an organism, part, or molecule that is a chimera: chimeric mice; chimeric proteins.
2. Relating to a monoclonal antibody produced from the cells of a nonhuman organism, usually a mouse, in which a portion of the antibody has been replaced with a human sequence of amino acids. This is done in the laboratory by replacing part of the DNA sequence in the nonhuman cells with a sequence of human DNA.
originally posted by: chr0naut
a reply to: ElectricUniverse
This is not saying that SARS-CoV-2 is a chimeric human made virus.
It is a ruling that SARS-CoV-2 is not to be used in future human made viruses. It is a ban on future experimentation that may use the virus as a basis.
...
Abstract
Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems. The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune levels of specific protein expression, achieving downregulation through short interfering RNA (siRNA) or upregulation by messenger RNA (mRNA) administration. Recent advances in the development of delivery vehicles, including nonviral nanoparticles are crucial to overcome the innate barriers to nucleic acid delivery. Toward this end, current clinical approaches have utilized mRNA and lipid nanoparticles (LNPs) to address the COVID-19 pandemic through novel vaccine strategies, producing efficacious vaccines within one year of sequencing the SARS-CoV-2 genome. Here, we review fundamental concepts required to achieve successful nucleic acid delivery, including the design of LNP systems optimized for mRNA vaccine applications.
...
To combat the SARS‐CoV‐2 pandemic, and many other diseases, nucleic acid vaccines appear to be a promising method.
...
...
Accordingly, nucleic acid-based treatments including aptamers and siRNAs are candidates that might be effective in COVID-19 treatment.
...
originally posted by: Antisocialist
a reply to: ElectricUniverse
This plandemic is just the first act, an experiment, in global population control.
Act 2, or the next plandemic will be a REAL killer. Expect it!
Therefore, to examine the emergence potential (that is, the potential to infect humans) of circulating bat CoVs, we built a chimeric virus encoding a novel, zoonotic CoV spike protein—from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats1—in the context of the SARS-CoV mouse-adapted backbone. The hybrid virus allowed us to evaluate the ability of the novel spike protein to cause disease independently of other necessary adaptive mutations in its natural backbone.
An experiment that created a hybrid version of a bat coronavirus — one related to the virus that causes SARS (severe acute respiratory syndrome) — has triggered renewed debate over whether engineering lab variants of viruses with possible pandemic potential is worth the risks.
In an article published in Nature Medicine1 on 9 November, scientists investigated a virus called SHC014, which is found in horseshoe bats in China. The researchers created a chimaeric virus, made up of a surface protein of SHC014 and the backbone of a SARS virus that had been adapted to grow in mice and to mimic human disease. The chimaera infected human airway cells — proving that the surface protein of SHC014 has the necessary structure to bind to a key receptor on the cells and to infect them. It also caused disease in mice, but did not kill them.
But other virologists question whether the information gleaned from the experiment justifies the potential risk. Although the extent of any risk is difficult to assess, Simon Wain-Hobson, a virologist at the Pasteur Institute in Paris, points out that the researchers have created a novel virus that “grows remarkably well” in human cells. “If the virus escaped, nobody could predict the trajectory,” he says.
originally posted by: ElectricUniverse
originally posted by: chr0naut
a reply to: ElectricUniverse
This is not saying that SARS-CoV-2 is a chimeric human made virus.
It is a ruling that SARS-CoV-2 is not to be used in future human made viruses. It is a ban on future experimentation that may use the virus as a basis.
Are you sure about that? First, there is plenty evidence that SARS-CoV has been manipulated in labs several years ago. For example.
Chimeric severe acute respiratory syndrome coronavirus (SARS-CoV) S glycoprotein and influenza matrix 1 efficiently form virus-like particles (VLPs) that protect mice against challenge with SARS-CoV
Second, the virus escaped from a Wuhan lab and even the Chinese doctors who warned the world about this chimeric virus were disappeared.
Chinese Doctor Disappears after Blowing the Whistle on Coronavirus Threat
The genetic structure of SARS-CoV-2 does not rule out a laboratory origin: SARS-COV-2 chimeric structure and furin cleavage site might be the result of genetic manipulation
Although the CDC does not state this directly it is implying that SARS/Cov-2 is a chimeric virus.
Third, this ban is not just for further experimentation to make new coronaviruses, but it is also a ban on making vaccines and treatments.
In specific the message states: "...adding SARS-CoV/SARS-CoV-2 chimeric viruses resulting from any deliberate manipulation of SARS-CoV-2 to incorporate nucleic acids coding for SARS-CoV virulence factors to the list of HHS select agents and toxins..."
The process to add/incorporate nucleic acids coding is necessary for vaccines as well as treatments.
...
Abstract
Nucleic acid therapeutics offer a new paradigm to rapidly respond to global health problems. The versatility of nucleic acids, especially in RNA therapies, provides the ability to tune levels of specific protein expression, achieving downregulation through short interfering RNA (siRNA) or upregulation by messenger RNA (mRNA) administration. Recent advances in the development of delivery vehicles, including nonviral nanoparticles are crucial to overcome the innate barriers to nucleic acid delivery. Toward this end, current clinical approaches have utilized mRNA and lipid nanoparticles (LNPs) to address the COVID-19 pandemic through novel vaccine strategies, producing efficacious vaccines within one year of sequencing the SARS-CoV-2 genome. Here, we review fundamental concepts required to achieve successful nucleic acid delivery, including the design of LNP systems optimized for mRNA vaccine applications.
Nucleic acid delivery and nanoparticle design for COVID vaccines
Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
Nucleic Acid Vaccine Technologies: DNA and mRNA
The promise of nucleic acid vaccines
...
To combat the SARS‐CoV‐2 pandemic, and many other diseases, nucleic acid vaccines appear to be a promising method.
...
Next‐Generation Vaccines: Nanoparticle‐Mediated DNA and mRNA Delivery
...
Accordingly, nucleic acid-based treatments including aptamers and siRNAs are candidates that might be effective in COVID-19 treatment.
...
Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAs
So in fact this rule does ban not just experimentation into forming new types of coronaviruses, but also making new vaccines against SARS/CoV-2, and also bans any treatments against SARS/CoV-2 from being used except by getting permission from the CDC.
Heck, by extension no scientist/group of scientists could even do any sort of experimentation into the current vaccines without the explicit consent from the CDC. This limits who can not just do experiments for new coronaviruses, but it limits scientists into creating or experimenting with any treatments and vaccines for COVID-19.
If you want to stop an illness (COVID-19), a pandemic as a matter of fact, from a virus such as SARS/CoV-2 you wouldn't put these limits on scientists. It is inefficient and inane.
originally posted by: BernnieJGato
a reply to: ElectricUniverse
I'm fairly sure that the CDC has no control of other countries research. They might be able to pull purse strings for like funding for gain of function, but as far as telling the UK, France, Israel, China, they can't do it would more than likely get a loud f you just as if they told the U.S. we couldn't.
originally posted by: MichiganSwampBuck
How can I be a conspiracy theorist? I've known this for over a year now.
21st Century Pandemic Timeline
It seems like most CTs I've studied are now being accepted as facts.
originally posted by: charlyv
Bull#, go back to playing with blocks.
This is the same kind of logic that is keeping this virus alive. There are so many uneducated people out there that have no idea what has been done to save so many people and they love reading # like this to further the disinformation that will probably kill them. along with others that are trying to help but are hindered by severely weakened immune systems. Go the # away.