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The Sirens of Titan largely deals with questions of free will, with multiple characters being stripped of it and the revelation that humanity had been secretly manipulated for millennia for an inane purpose, playing major roles in the story.
More broadly speaking, lack of agency has been a hallmark of Vonnegut's novels, with the protagonists struggling against forces they can never overcome and often can't comprehend.
None of the characters in The Sirens of Titan have chosen to be in their position, but are driven by forces and wills beside their own, and can do no more than try to make the best of it.
At the end of the book Constant concluded, "A purpose of human life, no matter who is controlling it, is to love whoever is around to be loved."