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C
Children are always going to find cunning ways to bunk off school, and the latest trick is to fake a positive Covid-19 lateral flow test (LFT) using soft drinks. [Videos of the trick have been circulating on TikTok since December and a school in Liverpool, UK, recently wrote to parents to warn them about it.] So how are fruit juices, cola and devious kids fooling the tests, and is there a way to tell a fake positive result from a real one? I’ve tried to find out.
First, I thought it best to check the claims, so I cracked open bottles of cola and orange juice, then deposited a few drops directly onto LFTs. Sure enough, a few minutes later, two lines appeared on each test, supposedly indicating the presence of the virus that causes Covid-19.
So, how can a soft drink cause the appearance of a red T line? One possibility is that the drinks contain something that the antibodies recognise and bind to, just as they do to the virus. But this is rather unlikely. The reason antibodies are used in tests like these is that they are incredibly fussy about what they bind to. There’s all sorts of stuff in the snot and saliva collected by the swabs you take from the nose and mouth, and the antibodies totally ignore this mess of protein, other viruses and remains of your breakfast. So they aren’t going to react to the ingredients of a soft drink.
A much more likely explanation is that something in the drinks is affecting the function of the antibodies. A range of fluids, from fruit juice to cola, have been used to fool the tests, but they all have one thing in common – they are highly acidic.
in acidic conditions, the protein becomes increasingly positively charged. As a result, many of the interactions that hold the protein together are disrupted, the delicate structure of the protein is affected and it no longer functions correctly. In this case, the antibodies’ sensitivity to the virus is lost.
Given this, you might expect that the acidic drinks would result in completely blank tests. But denatured proteins are sticky beasts. All of those perfectly evolved interactions that would normally hold the protein together are now orphaned and looking for something to bind to. A likely explanation is that the immobilised antibodies at the T-line stick directly to the gold particles as they pass by, producing the notorious cola-induced false positive result.
originally posted by: dug88
a reply to: OccamsRazor04
PCR...ah yes that test that works by detecting the presence of viruses based on the sensitivity of the test. The test that doesn't actually test for covid antibodies. Much more reliable I'm sure.
A recent Cochrane Review, which combined the results of multiple studies assessing the accuracy of LFTs, found that the average sensitivity of such tests was 72% among people with COVID-19 symptoms, and 58% for people without symptoms.
The nose swab PCR test for COVID-19 is the most accurate and reliable test for diagnosing COVID-19.
The major strength of this study lies in the large sample size (100,001 SARS-CoV-2 rtRT-PCR tests from 95,919 patients) from which discordant results were identified. Discordant results were found for 0.05% of all patients tested. Based on re-testing of 49 patients with discordant results, the FNR and sensitivity of our LDT in this subgroup of patients was approximately 9.3% and 90.7%, respectively.
originally posted by: KawRider9
a reply to: OccamsRazor04
I think the truth is preferable!
originally posted by: Trueman
a reply to: OccamsRazor04
OK, but where I am you don't do the test by yourself. There is a nurse in a lab doing the test with you.
originally posted by: OccamsRazor04
a reply to: Trueman
In my hospital we do the test, as crazy as it sounds, other local hospitals and clinics are having people self test.
originally posted by: OccamsRazor04
a reply to: nonspecific
Yes, because you are unlikely to go as far as necessary to do the test correctly. I go way up, whereas the do it yourself is barely in the nose. You will get way more false negatives.
originally posted by: dug88
a reply to: OccamsRazor04
PCR...ah yes that test that works by detecting the presence of viruses based on the sensitivity of the test. The test that doesn't actually test for covid antibodies. Much more reliable I'm sure.
originally posted by: nonspecific
Here in the UK you do the PCR test yourself.
Sit in your car and swab in tha back of the throat then up one nostril. Put it in a vial and then a medibag and it gets taken to the lab via currier.
originally posted by: Trueman
a reply to: OccamsRazor04
OK, but where I am you don't do the test by yourself. There is a nurse in a lab doing the test with you.