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Studies have shown the P.1 is highly resistant to neutralizing antibodies, whether from vaccines or natural infection. Mutations to the receptor-binding domain, the mechanism which connects to the ACE2 receptor of the human cell, likely drive this resistance.
Recently released data on the Astrazeneca vaccine indicate neutralization efficacy of only 10%. This is notable as the Brazilian, Japanese, and now Philippine variants all bear significant commonality with the South African variant. There is a substantial possibility that the vaccine would struggle with these other variants as well.
Development of new vaccines to cater to these variants is already underway. However, who is to say that those second-generation vaccines will be capable of neutralizing the Japanese or Philippine variant? Perhaps then a third-generation vaccine will be developed, and the game of whack-a-mole continues.
Two doses of the AstraZeneca Covid-19 vaccine were found to have only a 10.4% efficacy against mild-to-moderate infections caused by the B.1.351 South Africa variant, according to a phase 1b-2 clinical trial published on Tuesday in the New England Journal of Medicine. This is a cause for grave concern as the South African variants share similar mutations to the other variants leaving those vaccinated with the AstraZeneca vaccine potentially exposed to multiple variants.
originally posted by: FamCore
a reply to: infolurker
The scary thing is I know many, many friends & family members who will probably go along with getting "the new" vaccines if the current ones they've already gotten aren't effective...
It's such a sensitive topic even with the people closest to me in my life, but I also believe in allowing people to make their own choices.
originally posted by: ketsuko
This information is with the AstraZeneca vaccine which is substantially different again in how it is made than either the Pfizer and Moderna ones or the J&J one. So just because the AZ vax isn't offering good coverage doesn't mean the other three are going to be the same way when it comes to the variants.
originally posted by: cooperton
Now we're starting to see the futility of trying to neutralize this thing with vaccines. It is a waste of time and money. Make effort to stay healthy and you are extremely likely to survive infection. Natural immunity is far more efficacious than vaccines.