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originally posted by: TheAMEDDDoc
a reply to: rickymouse
The article is kind of nuts. They also combine steps, completely skip entire processes that are kind of important and then use random quotes from really smart people. Plus, as long as the tumor cells aren’t your own cancerous cells with familiar antigen, you should be good to go. Well, as long as you aren’t missing a thymus or T-cells. Then you could be in trouble....
originally posted by: rickymouse
Hmmm. Using human tumor cells in a vaccine, with an adjuvant? That sounds insane. Half the tumors out there are cells from other organs that are growing in the wrong place. Lung cells growing in the liver and stuff like that. So, making the body target liver cells or lung cells would trigger autoimmune problems.
I do not know if the information in that article is even close to correct, hopefully it isn't.
originally posted by: TheAMEDDDoc
a reply to: rickymouse
Only if it’s not a typing match. In a pinch you can deviate from the standardized process of blood typing and it’s the repeat exposures that are more life threatening. What’s weird though is getting into HLA matching and even with the same or similar blood type over and over again, a reaction may occur eventually.
T cells are a major contributor of why cancer isn’t contagious, plus there is a huge array of communication between cells to prevent issues.
Articles get held up on stuff like this because we use immortal cells which can be cancer cells, stem cells (which we can induce) or fetal cells. But from your line of work you know how important it is to have specific immortal lines of cells to test our methods and it gives us absolute control of the variables in vitro. Just because a cell was at one time derived from a cancerous cell does not mean it’s going to give you cancer. There also shouldn’t be DNA changes either because our cells package and protect it unless it’s being replicated or transcribed into RNA. It would be like saying because a vaccine is grown in monkey cells you’re going to change into a non-human primate.
Now an RNA vaccine could cause autoimmune issues because your own cells produce and express the viral proteins, it’s why I’m waiting a bit on those vaccines.