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Thus, the high-affinity binding of the SARS-CoV-2 spike protein to human ACE2 is most likely the result of natural selection on a human or human-like ACE2 that permits another optimal binding solution to arise. This is strong evidence that SARS-CoV-2 is not the product of purposeful manipulation.
Instead, we propose two scenarios that can plausibly explain the origin of SARS-CoV-2: (i) natural selection in an animal host before zoonotic transfer; and (ii) natural selection in humans following zoonotic transfer.
This clearly shows that the SARS-CoV-2 spike protein optimized for binding to human-like ACE2 is the result of natural selection.
Mutations, insertions and deletions can occur near the S1–S2 junction of coronaviruses22, which shows that the polybasic cleavage site can arise by a natural evolutionary process.
For example, a future observation of an intermediate or fully formed polybasic cleavage site in a SARS-CoV-2-like virus from animals would lend even further support to the natural-selection hypotheses.
originally posted by: LookingAtMars
a reply to: The2Billies
I am not sure we should be so fast to blame China for releasing this virus. Don't get me wrong, there is plenty of blame to lay at their feet concerning this pandemic. It may very well be a Chinese virus.
But this virus could of been released by a number of nations, maybe even the US. It could have been released by terrorists, a cabal or even a lone wolf.
I think there are a number of things that point to this virus being made in a lab. I also believe that the truth will come out sooner or later.
originally posted by: TzarChasm
It would help our studies of fatality statistics to know the medical background and coroner reports from these Covid19 patients who died while infected. Different accounts suggest this disease is not the reason they died.
originally posted by: McGinty
I think that it is an accidental release as they would have a vaccine ready for themselves first before releasing it deliberately.
The researchers analysed genomic data available from SARS-CoV-2 and other similar coronaviruses, showing that the receptor-binding domain (RBD) sections of SARS-CoV-2 spike proteins were so effective at binding to human cells, they had to be caused by natural selection.
"By comparing the available genome sequence data for known coronavirus strains, we can firmly determine that SARS-CoV-2 originated through natural processes," said one of the researchers, immunologist Kristian Andersen at Scripps Research.
"Two features of the virus, the mutations in the RBD portion of the spike protein and its distinct backbone, rules out laboratory manipulation as a potential origin for SARS-CoV-2."