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The storm or sepsis results from a delayed interferon response.
originally posted by: DBCowboy
a reply to: DontTreadOnMe
I have to ask the question, why isn't a healthy diet good enough?
Why does our body need "more" of this or that to stave off disease?
originally posted by: DontTreadOnMe
Anyone familiar with the cytokine storm, the immune system and viruses please add your feedback here.
I know some things we take for illness and viruses can actually make you sicker.
For coronavirus, at lest the bird flu kind is recommended.
Two things you probably didn't think you'd hear together: COVID-19 and rattlesnake venom. No, it's not some new miracle cure. A University of Arizona research team is part of a new study looking at the two to hopefully stop future COVID-19 deaths.
Chilton is part of a study by multiple universities just published in the Journal of Clinical Investigation that found in extremely ill COVID-19 patients, a very similar enzyme that's found in rattlesnake venom was found in these patients, and at astronomical levels that could be causing the death.
"We saw the highest levels of this enzyme we've ever seen in humans and those patients died from the disease," Chilton said. "It's very similar to the rattlesnake and it has many similar properties and much of the biology is the same."
UArizona study found enzyme in COVID deaths similar to rattlesnake venom
Concentrations of venom and extract vary with the experiment and are shown in the Results section. For assays testing the inhibition of the enzyme activity in venoms, a concentration of enzyme was incubated for 15 min with the inhibitor, then substrate added and the reaction conducted for a sufficient length of time to demonstrate effective enzyme activity in the positive controls, typically 1-2 h.
While mechanisms are generally unclear, many low molecular weight nonnitrogenous antivenom compounds in plant extracts may mimic natural inhibitors of the venoms , explaining this use , while others are nonspecific inhibitors of enzymes, either as direct inhibitors of venom components or maybe anti-inflammatory
Eryngium genus displays anti-inflammatory [40-49], anti-microbial and anti-oxidant effects [30,50]. Anti-venom protection by Eryngium water extract significantly prolongs survival time of guinea pigs challenged with scorpion (Leiurus quinquestriatus) venom [51-53]. This type extract also inhibited the hemolytic activity of Cerastes cerastes (desert horned viper) highly proteolytic venom . The aqueous root extract of Eryngium creticum reduces the hyperglycemic response caused by Cerastes ceras in rats . Given the variety of activities documented for Eryngium, and that there is a documented effect of the E. creticum plant inhibiting both snake and on scorpion venoms, there seems good support for the Eryngium extracts as an anti-venom treatment, to which this study adds.
The work reported here adds in vitro protease inhibition, a specific mechanism for the actions of the Eryngium extracts, as shown with a panel of North American venomous snakes, most noticeable in the general protease and the collagenase assays and provides a system to further study the inhibitors. The presence of the enzyme inhibition activity in all the plant parts tested and not only the roots, should be of interest to phytochemists.
Using a comparison at a dilution of 2 as an example, the statistical groupings by Tukey’s multiple range test (P < 0.05) were: E. yuccifolium leaves/sage were the most potent, E. yuccifolium roots (different from sage but not E. leaves)
An in vitro evaluation of the Native American ethnomedicinal plant Eryngium yuccifolium as a treatment for snakebite envenomation
Researchers in Germany have conducted a study demonstrating the potential antiviral effects of commonly consumed herbal teas on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the pathogen that causes coronavirus disease 2019 (COVID-19).
The team – from the University of Duisburg-Essen – found that aqueous infusions of sage and perilla elicited potent antiviral activity against the virus in different human cell lines.
Sage and perilla herbal teas could help to prevent or treat COVID-19